Syracuse vs Louisville Point Spread, Over/Under, Moneyline & Prediction for College Football Week 11

Isaiah De Los Santos
Syracuse Orange vs Louisville Cardinals prediction, odds, spread, over/under and betting trends for college football Week 11 game.
Syracuse Orange vs Louisville Cardinals prediction, odds, spread, over/under and betting trends for college football Week 11 game. / Andy Lyons/GettyImages
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Week 11's slate of NCAA college football games includes a showdown between the Syracuse Orange and Louisville Cardinals.

Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.

Syracuse vs Louisville Point Spread

The Cardinals are 3.5-point home favorites against the Orange. Louisville is +104 to cover the spread, while Syracuse is -128 to cover as the 3.5-point underdog.

Syracuse vs Louisville Over/Under

The over/under for the Syracuse vs Louisville Week 11 college football matchup is set at 55.5, with -110 odds on the over and -110 odds on the under.

Syracuse vs Louisville Moneyline

The Orange vs Cardinals moneyline has Louisville as a -162 favorite, while Syracuse is the +132 underdog on the road.

Syracuse vs Louisville Betting Trends

- Louisville is 12-7 in 19 all-time head-to-head matchups against Syracuse.
- Louisville defeated Syracuse, 30-0, in their last meeting on Nov. 20, 2020.
- Syracuse is 1-6 against the spread (ATS) in its last seven games against Louisville.
- The total has hit the over in four of Syracuse's last six games against Louisville.
- The total has hit the under in six of Louisville's last nine games.

Syracuse vs Louisville Prediction 

All NCAAF predictions & expert picks are according to numberFire.
Prediction: Louisvilee wins (67.9%)

Syracuse vs Louisville Odds

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: SYR: (+132) | LOU: (-162)
Spread: SYR: +3.5 (-128) | LOU: -3.5 (+104)
Total: 55.5 – Over: (-110) | Under: (-110)


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Isaiah De Los Santos is not a FanDuel employee. In addition to providing DFS gameplay advice, Isaiah De Los Santos also participates in DFS contests on FanDuel using his personal account, username zayyy05328. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

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