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Indiana vs Cincinnati Prediction, Odds & Betting Trends for College Football Week 4 Game on FanDuel Sportsbook

Devon Platana
Indiana vs. Cincinnati prediction, odds and betting trends for NCAA college football game.
Indiana vs. Cincinnati prediction, odds and betting trends for NCAA college football game. / Karl B DeBlaker / Associated Press

Indiana vs Cincinnati Week 4 Game Info

2022 NCAA College Football Game
Indiana Hoosiers (3-0) vs. Cincinnati Bearcats (2-1)
Date: Saturday, Sept. 24, 2022
Time: 3:30 p.m. ET
Venue: Nippert Stadium — Cincinnati, OH
Coverage: ESPN2

Week 4 of the 2022 NCAA college football season includes a showdown between the Indiana Hoosiers and Cincinnati Bearcats. The Hoosiers looked like they were poised to lose their first game of the year last week before a 17-point fourth quarter forced overtime against Western Kentucky, allowing Cincinnati to leave with the 33-30 win.

Cincinnati was also victorious last week, scoring a 38-17 win over Miami (OH). Several Bearcats players stuck out for their role in the win, including running back Charles McClelland, who turned 18 carries into 101 rushing yards and a pair of touchdowns. Meanwhile, wideouts Tyler Scott and Tre Tucker combined for 15 receptions, 224 yards and a TD.

Indiana vs Cincinnati Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IU: (+570) | CIN: (-850)
Spread: IU: +16.5 (-106) | CIN: -16.5 (-114)
Total: 56.5 — Over: (-110) | Under: (-110)

Cincinnati enters this contest as the favorite on the spread. This 3:30 p.m. ET clash also features a total of 56.5, which is higher than average compared to the rest of this week's college football projected totals.

Indiana vs Cincinnati Prediction & Pick

After winning five straight games against Cincinnati, Indiana came up short in their most recent meeting last year, falling 38-24. Now, the odds are projecting for another one-sided Bearcats victory and it's hard to disagree with them.

Even though the Hoosiers have faced lesser opponents this season, only one of those wins came by more than three points. Yes, the Bearcats have lost, but that was to Arkansas — a team ranked in the top 10 this week. Since then, Cincinnati has outscored its opponents 101-27, which spells bad news for an Indiana squad that's come close to losing multiple times.

Final Score Prediction: Cincinnati: 35 | Indiana: 16

Indiana vs Cincinnati Betting Trends

- Indiana is 0-9 straight up in its last nine games as the underdog.
- Cincinnati is 4-1 against the spread (ATS) in its last five games as the favorite.
- The total has hit the over in four of Indiana's last five games.
- The total has hit the over in five of Cincinnati's last six games played in September.

Indiana vs Cincinnati Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

As shown by the above trends, Indiana doesn't do well as the underdog, whereas Cincinnati has been consistently covering the spread as the favorite. The Bearcats' defense will be the difference here and will be too much for the Hoosiers' offense to overcome.

Throw in the fact that Indiana is 1-5 ATS in its last six road games and I like Cincinnati to cover here.

Bet: Cincinnati -16.5 (-114)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.