Full Cardinals 2022 Schedule: List of Arizona Opponents This NFL Season
By Larry Rupp

The 2022-23 NFL regular-season schedule will be released on Thursday, May 12. The official release will let the Arizona Cardinals know when and where they'll play throughout the year since they already know who their opponents are.
2022 Cardinals Schedule
Here's everything we know so far about the Cardinals' schedule in 2022.
Arizona Cardinals Football Schedule 2022
Arizona will find out its entire schedule for the 2022-23 regular season on Thursday, May 12. The official schedule release is slated to air on NFL Network at 8 p.m. ET. This article will be updated once the full schedule has been released.
Cardinals Week 1 Opponent
The Arizona Cardinals' Week 1 matchup has not been officially revealed yet. Last season, they opened with a road game against the Tennessee Titans on Sunday Sept. 12, 2021.
Cardinals 2022 Strength of Schedule
According to ESPN's Mike Clay, the Cardinals have the ninth-hardest schedule in the NFL for the 2022 campaign.
Early 2022 NFL Strength of Schedule based on current rosters.
— Mike Clay (@MikeClayNFL) March 28, 2022
Note that the opponents are correct, but the order is not (s/o @OneSideburn) pic.twitter.com/9mParlm0Jy
Cardinals Home Games 2022
- Los Angeles Rams
- San Francisco 49ers
- Seattle Seahawks
- Tampa Bay Buccaneers
- New Orleans Saints
- Kansas City Chiefs
- Los Angeles Chargers
- Philadelphia Eagles
- New England Patriots
Cardinals Away Games 2022
- Los Angeles Rams
- San Francisco 49ers
- Seattle Seahawks
- Atlanta Falcons
- Carolina Panthers
- Las Vegas Raiders
- Denver Broncos
- Minnesota Vikings
Cardinals Opponents Record 2022
The Cardinals' opponents went 157-132 during the 2021-22 NFL season.
Cardinals 17th Game Opponent
The NFL officially added an extra 17th game to the schedule starting in 2021. It has been revealed that the Cardinals will host the New England Patriots in that contest.
Cardinals International Game 2022
The Cardinals are one of 10 teams playing in an international game during the 2022-23 regular season. Arizona will be the "home" team against the San Francisco 49ers on Nov. 21 at Estadio Azteca in Mexico City, Mexico.
Cardinals Super Bowl Odds
The Cardinals are currently +2700 (No. 14) in FanDuel Sportsbook's latest Super Bowl odds.
Cardinals Win Total Odds
Arizona is listed with a win total of 9.5 for the 2022-23 regular season. The Cardinals are +135 to hit the over, and -160 to hit the under.
Cardinals Win Total Prediction 2022
The Cardinals' roster saw a lot of turnover in the offseason as impact players Christian Kirk and Chandler Jones departed in free agency. A trade for wide receiver Marquise Brown solved Arizona's pass-catching depth issues until All-Pro DeAndre Hopkins was handed a six-game suspension. With the drama surrounding quarterback Kyler Murray's contract situation, it's hard to see him wreaking havoc with a schedule that features 11 matchups against teams that finished above .500 in 2021.
Bet – Cardinals: Under 9.5 Wins (-160)
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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.