Colts vs Cardinals Point Spread, Over/Under, Moneyline and Betting Trends for NFL Week 16 Game

Adam Taylor McKillop
Colts vs Cardinals point spread, over/under, moneyline and betting trends for Week 16 NFL game.
Colts vs Cardinals point spread, over/under, moneyline and betting trends for Week 16 NFL game. / Andy Lyons/GettyImages
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Week 16's slate of games includes a showdown between the Indianapolis Colts and Arizona Cardinals.

Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.

Colts vs Cardinals Point Spread

The Cardinals are 1.5-point home favorites against the Colts. Arizona is -108 to cover the spread, while Indianapolis is -112 to cover as a 1.5-point underdog.

Colts vs Cardinals Over/Under

The over/under for the Colts vs Cardinals Week 16 NFL matchup is set at 48.5, with -118 odds on the over and -104 odds on the under.

Colts vs Cardinals Moneyline

The Colts vs Cardinals moneyline has Arizona as a -116 favorite, while Indianapolis is a -102 underdog on the road.

Colts vs Cardinals Betting Trends

- Indianapolis is 5-0 against the spread (ATS) in its last five road games.
- Arizona is 3-8 ATS in its last 11 home games.
- The total has hit the over in five of Indianapolis' last six games against NFC opponents.
- The total has hit the under in six of Arizona's last seven games against Indianapolis.

Colts vs Cardinals Prediction

All NFL predictions and picks are from numberFire's projection model and will be updated when available.
Prediction: Arizona Cardinals win (53.8%)

Colts vs Cardinals Odds

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (-102) | ARI: (-116)
Spread: IND: +1.5 (-112) | ARI: -1.5 (-108)
Total: 48.5 — Over: (-118) | Under: (-104)
Odds to Win Super Bowl LVI: IND: (+1900) | ARI: (+1500)


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Adam Taylor McKillop is not a FanDuel employee. In addition to providing DFS gameplay advice, Adam Taylor also participates in DFS contests on FanDuel using his personal account, username atmckillop. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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