NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 12

The Week 12 NFL Sunday schedule has plenty of exciting matchups in store. Among those contests is the Detroit Lions playing the Indianapolis Colts.

Check out our betting breakdown for the NFL's Week 12 action on Sunday.

Colts vs. Lions

Jahmyr Gibbs will lead the Detroit Lions into their game against the Indianapolis Colts at Lucas Oil Stadium on Sunday at 1 p.m. ET.

• Matchup: Detroit Lions at Indianapolis Colts
• Projected Favorite: Lions (65.39% win probability)
• Spread: Detroit (-7.5)
• Total: 50.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Indianapolis vs. Detroit with FanDuel Sportsbook.

Texans vs. Titans

C.J. Stroud and the Houston Texans (7-4) will get a challenge when they collide with the Tennessee Titans (2-8), who have the NFL's best pass defense, on Sunday, Nov. 24 at 1 p.m. ET. Stroud ranks fifth-best in the league in passing yards.

• Matchup: Tennessee Titans at Houston Texans
• Projected Favorite: Texans (76.58% win probability)
• Spread: Houston (-7.5)
• Total: 40.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Tennessee with FanDuel Sportsbook.

Panthers vs. Chiefs

Chuba Hubbard, who ranks fourth-best in the league in rushing yards, will try to lead the charge for the Carolina Panthers (3-7) on Nov. 24 at 1 p.m. ET, when they host the Kansas City Chiefs (9-1) and their third-best run defense (85.3 rushing yards allowed per game).

• Matchup: Kansas City Chiefs at Carolina Panthers
• Projected Favorite: Chiefs (71.15% win probability)
• Spread: Kansas City (-10.5)
• Total: 43.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Carolina vs. Kansas City with FanDuel Sportsbook.

Dolphins vs. Patriots

When the Miami Dolphins (4-6) and the New England Patriots (3-8) meet on Sunday, Nov. 24 at 1 p.m. ET, the Dolphins will be aiming to follow up their recent victory over the Raiders with another win, and the Patriots will be trying to rebound from a loss to the Rams.

• Matchup: New England Patriots at Miami Dolphins
• Projected Favorite: Dolphins (70.50% win probability)
• Spread: Miami (-7.5)
• Total: 45.5 -- Over: (-114) | Under: (-106)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Miami vs. New England with FanDuel Sportsbook.

Bears vs. Vikings

Justin Jefferson will lead the Minnesota Vikings into their matchup against the Chicago Bears at Soldier Field on Sunday at 1 p.m. ET.

• Matchup: Minnesota Vikings at Chicago Bears
• Projected Favorite: Vikings (65.37% win probability)
• Spread: Minnesota (-3)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. Minnesota with FanDuel Sportsbook.

Giants vs. Buccaneers

The Tampa Bay Buccaneers (4-6), who rank fifth in the league at 27.9 points per game, look to be in a very good spot on Sunday, Nov. 24 at 1 p.m. ET, as they get to square off against the New York Giants (2-8), who own the league's worst scoring offense (15.6 points per game).

• Matchup: Tampa Bay Buccaneers at New York Giants
• Projected Favorite: Buccaneers (64.75% win probability)
• Spread: Tampa Bay (-6.5)
• Total: 40.5 -- Over: (-102) | Under: (-120)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Tampa Bay with FanDuel Sportsbook.

Commanders vs. Cowboys

CeeDee Lamb and the Dallas Cowboys (3-7) will get a challenge when they go toe to toe with the Washington Commanders (7-4), who have the league's fifth-best pass D, on Sunday, Nov. 24 at 1 p.m. ET. Lamb ranks fourth-best in the league in receiving yards.

• Matchup: Dallas Cowboys at Washington Commanders
• Projected Favorite: Commanders (86.08% win probability)
• Spread: Washington (-10.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. Dallas with FanDuel Sportsbook.

Raiders vs. Broncos

The Denver Broncos (6-5), who secured the win against the Falcons in their previous game, visit the Las Vegas Raiders (2-8) at Allegiant Stadium on Nov. 24 at 4:05 p.m. ET. The Raiders were taken down by the Dolphins in their last game.

• Matchup: Denver Broncos at Las Vegas Raiders
• Projected Favorite: Broncos (74.33% win probability)
• Spread: Denver (-5.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Denver with FanDuel Sportsbook.

Seahawks vs. Cardinals

After clinching a 20-17 victory against the 49ers in their last game, the Seattle Seahawks (5-5) will host the Arizona Cardinals (6-4), who are coming off a 31-6 win over the Jets, at Lumen Field. Kickoff is scheduled for 4:25 p.m. ET on Sunday, Nov. 24.

• Matchup: Arizona Cardinals at Seattle Seahawks
• Projected Favorite: Cardinals (51.56% win probability)
• Spread: Seattle (-1.5)
• Total: 47.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Seattle vs. Arizona with FanDuel Sportsbook.

Packers vs. 49ers

Jayden Reed and the Green Bay Packers face the San Francisco 49ers on Sunday at 4:25 p.m. ET, at Lambeau Field.

• Matchup: San Francisco 49ers at Green Bay Packers
• Projected Favorite: Packers (64.41% win probability)
• Spread: Green Bay (-5.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Green Bay vs. San Francisco with FanDuel Sportsbook.

Rams vs. Eagles

On Sunday at 8:20 p.m. ET, a pair of the top offensive performers in football will be on display when quarterback Jalen Hurts and the Philadelphia Eagles visit running back Kyren Williams and the Los Angeles Rams.

• Matchup: Philadelphia Eagles at Los Angeles Rams
• Projected Favorite: Eagles (53.66% win probability)
• Spread: Philadelphia (-3)
• Total: 48.5 -- Over: (-115) | Under: (-105)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on Los Angeles vs. Philadelphia with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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