NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 18

The Seattle Seahawks versus the San Francisco 49ers is a game to see on a Week 18 NFL schedule that includes a lot of compelling matchups.

If you're seeking additional betting intel for Week 18 in the NFL, we have you covered with odds for each of the important matchups.

Buccaneers vs. Panthers

When the Tampa Bay Buccaneers (7-9) and the Carolina Panthers (8-8) play on Saturday, Jan. 3 at 4:30 p.m. ET, they will both be looking to right the ship after losing their previous contest. The Buccaneers lost 20-17 to the Dolphins, and the Panthers are coming off a 27-10 loss to the Seahawks.

• Game Preview: Carolina Panthers at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (52.56% win probability)
• Spread: Tampa Bay (-3)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 4:30 p.m. ET
• Channel: ABC/ESPN

Bet on Tampa Bay vs. Carolina with FanDuel Sportsbook.

49ers vs. Seahawks

At Levi's Stadium on Saturday, Jaxon Smith-Njigba and the Seattle Seahawks (13-3) play Christian McCaffrey and the San Francisco 49ers (12-4) in a battle featuring two outstanding pass-catchers, beginning at 8 p.m. ET.

• Game Preview: Seattle Seahawks at San Francisco 49ers
• Spread: Seattle (-2.5)
• Total: 47.5 -- Over: (-110) | Under: (-110)
• Time: 8 p.m. ET
• Channel: ABC/ESPN

Bet on San Francisco vs. Seattle with FanDuel Sportsbook.

Vikings vs. Packers

The Minnesota Vikings (8-8) are slated to take on the Green Bay Packers (9-6-1) at U.S. Bank Stadium on Sunday, Jan. 4 at 1 p.m. ET. In their last tilts, the Vikings defeated the Lions 23-10, and the Packers lost 41-24 to the Ravens.

• Game Preview: Green Bay Packers at Minnesota Vikings
• Projected Favorite: Vikings (72.34% win probability)
• Spread: Minnesota (-11.5)
• Total: 36.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Minnesota vs. Green Bay with FanDuel Sportsbook.

Jaguars vs. Titans

Travis Etienne will lead the Jacksonville Jaguars (12-4) into their battle versus the Tennessee Titans (3-13) at EverBank Stadium on Sunday at 1 p.m. ET.

• Game Preview: Tennessee Titans at Jacksonville Jaguars
• Projected Favorite: Jaguars (87.12% win probability)
• Spread: Jacksonville (-13.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Jacksonville vs. Tennessee with FanDuel Sportsbook.

Falcons vs. Saints

When the Atlanta Falcons (7-9) and the New Orleans Saints (6-10) match up on Sunday, Jan. 4 at 1 p.m. ET, they will both be looking to maintain momentum after winning their last contest. The Falcons won 27-24 versus the Rams, and the Saints are coming off a 34-26 victory over the Titans.

• Game Preview: New Orleans Saints at Atlanta Falcons
• Projected Favorite: Falcons (56.45% win probability)
• Spread: Atlanta (-3.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Atlanta vs. New Orleans with FanDuel Sportsbook.

Bengals vs. Browns

Ja'Marr Chase, who ranks fourth-best in the league in receiving yards, will try to lead the charge for the Cincinnati Bengals (6-10) on Jan. 4 at 1 p.m. ET, when they host the Cleveland Browns (4-12) and their second-best pass D (163.8 passing yards allowed per game).

• Game Preview: Cleveland Browns at Cincinnati Bengals
• Projected Favorite: Bengals (68.94% win probability)
• Spread: Cincinnati (-8.5)
• Total: 45.5 -- Over: (-106) | Under: (-114)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. Cleveland with FanDuel Sportsbook.

Giants vs. Cowboys

The Dallas Cowboys (7-8-1), who took home the win against the Commanders in their last tilt, visit the New York Giants (3-13) at MetLife Stadium on Jan. 4 at 1 p.m. ET. The Giants picked up the win against the Raiders in their last game.

• Game Preview: Dallas Cowboys at New York Giants
• Projected Favorite: Cowboys (59.91% win probability)
• Spread: Dallas (-3)
• Total: 49.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Dallas with FanDuel Sportsbook.

Texans vs. Colts

Star running back Jonathan Taylor and the Indianapolis Colts (8-8) play the Houston Texans (11-5) on Sunday at 1 p.m. ET, at NRG Stadium.

• Game Preview: Indianapolis Colts at Houston Texans
• Projected Favorite: Texans (71.24% win probability)
• Spread: Houston (-9.5)
• Total: 38.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Indianapolis with FanDuel Sportsbook.

Patriots vs. Dolphins

When the New England Patriots (13-3) and the Miami Dolphins (7-9) match up on Sunday, Jan. 4 at 4:25 p.m. ET, they will both be aiming to maintain momentum after winning their last contest. The Patriots won 42-10 against the Jets, and the Dolphins are coming off a 20-17 victory over the Buccaneers.

• Game Preview: Miami Dolphins at New England Patriots
• Projected Favorite: Patriots (80.61% win probability)
• Spread: New England (-13.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on New England vs. Miami with FanDuel Sportsbook.

Rams vs. Cardinals

On Sunday at 4:25 p.m. ET, a pair of the top offensive players in football will be featured when running back Kyren Williams and the Los Angeles Rams (11-5) host Trey McBride and the Arizona Cardinals (3-13).

• Game Preview: Arizona Cardinals at Los Angeles Rams
• Projected Favorite: Rams (88.68% win probability)
• Spread: Los Angeles (-14.5)
• Total: 47.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Arizona with FanDuel Sportsbook.

Raiders vs. Chiefs

One of the top pass-catchers in football will be on show when Travis Kelce and the Kansas City Chiefs (6-10) visit the Las Vegas Raiders (2-14) on Sunday, January 4, 2026.

• Game Preview: Kansas City Chiefs at Las Vegas Raiders
• Projected Favorite: Chiefs (64.86% win probability)
• Spread: Kansas City (-4.5)
• Total: 36.5 -- Over: (-104) | Under: (-118)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Kansas City with FanDuel Sportsbook.

Eagles vs. Commanders

The Philadelphia Eagles (11-5) and Saquon Barkley, one of the NFL's top runners, should have a big day running the ball on Sunday, as the Washington Commanders (4-12) own the 31st-ranked run defense in the league. The two teams will collide at 4:25 p.m. ET on Jan. 4.

• Game Preview: Washington Commanders at Philadelphia Eagles
• Projected Favorite: Eagles (70.50% win probability)
• Spread: Philadelphia (-3.5)
• Total: 38.5 -- Over: (-112) | Under: (-108)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Philadelphia vs. Washington with FanDuel Sportsbook.

Broncos vs. Chargers

On Sunday, Jan. 4 at 4:25 p.m. ET, the Denver Broncos (13-3) will try to build upon their recent 20-13 win over the Chiefs when they match up with the Los Angeles Chargers (11-5) at Empower Field at Mile High. The Chargers lost their previous contest 20-16 to the Texans.

• Game Preview: Los Angeles Chargers at Denver Broncos
• Projected Favorite: Broncos (75.38% win probability)
• Spread: Denver (-13.5)
• Total: 37.5 -- Over: (-112) | Under: (-108)
• Time: 4:25 p.m. ET

Bet on Denver vs. Los Angeles with FanDuel Sportsbook.

Bills vs. Jets

After losing 13-12 to the Eagles in their last contest, the Buffalo Bills (11-5) will host the New York Jets (3-13), who are coming off a 42-10 loss to the Patriots, at Highmark Stadium. The game is scheduled for 4:25 p.m. ET on Sunday, Jan. 4.

• Game Preview: New York Jets at Buffalo Bills
• Projected Favorite: Bills (88.14% win probability)
• Spread: Buffalo (-10.5)
• Total: 37.5 -- Over: (-118) | Under: (-104)
• Time: 4:25 p.m. ET

Bet on Buffalo vs. New York with FanDuel Sportsbook.

Bears vs. Lions

Against the Chicago Bears (11-5), who have the 28th-ranked run defense this season, Jahmyr Gibbs and the Detroit Lions (8-8) shouldn't have any trouble running the ball when the two teams match up on Sunday, Jan. 4 at 4:25 p.m. ET. Gibbs has been one of the NFL's top rushers this season, ranking ninth-best in the league in rushing yards.

• Game Preview: Detroit Lions at Chicago Bears
• Projected Favorite: Bears (63.69% win probability)
• Spread: Chicago (-3.5)
• Total: 50.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Chicago vs. Detroit with FanDuel Sportsbook.

Steelers vs. Ravens

Star running back Derrick Henry and the Baltimore Ravens (8-8) meet the Pittsburgh Steelers (9-7) on Sunday at 8:20 p.m. ET at Acrisure Stadium.

• Game Preview: Baltimore Ravens at Pittsburgh Steelers
• Projected Favorite: Ravens (59.45% win probability)
• Spread: Baltimore (-3.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Pittsburgh vs. Baltimore with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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