Duke vs Louisville Spread, Line, Odds, Predictions, Over/Under & Betting Insights for College Basketball Game

By David Hayes
Duke vs Louisville prediction, pick and odds for NCAAM game.
Duke vs Louisville prediction, pick and odds for NCAAM game. / Andy Lyons/Getty Images

Duke vs Louisville Basketball Game Info

Duke Blue Devils (5-4, 3-2 ACC) vs. Louisville Cardinals (9-3, 4-2 ACC)
Date: Saturday, Jan. 23, 2021
Time: 4 p.m. EST
Venue: KFC Yum! Center – Louisville, KY
Coverage: ESPN

Duke vs Louisville Spread & Odds

All betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: DUKE: (+132) | LOU: (-156)
Spread: DUKE: +2.5 (-104) | LOU: -2.5 (-118)
Total: 141.5 – Over: (-106) | Under: (-114)
Public (Spread) Betting Percentages via oddsFireDUKE: (23%) | LOU: (77%)

Duke vs Louisville Prediction & Pick

All college basketball win probability predictions and picks are according to the ESPN Basketball Power Index (BPI).
Duke: 43.2%
Louisville: 56.8%

Duke vs Louisville Head-to-Head Results & Betting Trends

- Louisville defeated Duke, 79-73, in the most recent meeting between these teams on Jan. 18, 2020.
- Duke is 3-2 in the last five head-to-head matchups against Louisville.
- Duke is 6-4 in the last 10 head-to-head matchups against Louisville.
- Duke lost to Pittsburgh, 79-73, in its most recent game on Jan. 19, 2021.
- Louisville lost to Florida State, 78-65, in its most recent game on Jan. 18, 2021.

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David Hayes is not a FanDuel employee. In addition to providing DFS gameplay advice, David Hayes also participates in DFS contests on FanDuel using his personal account, username DavidWHayes. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.