Houston vs Colorado College Basketball Prediction, Odds, Picks, Best Bets for Feb. 28

The Colorado Buffaloes (16-12, 6-9 Big 12) will look to end a six-game road losing streak when they take on the Houston Cougars (23-5, 11-4 Big 12) on February 28, 2026 at Fertitta Center.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Houston vs. Colorado Game Info and Odds

• Game day: Saturday, February 28, 2026
• Game time: 12 p.m. ET
• TV channel: ESPN2
• Location: Houston, Texas
• Arena: Fertitta Center

Houston vs. Colorado Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Houston win (88.8%)

Take a look at some betting insights for Houston (-20.5) versus Colorado on Saturday. The total is set at 138.5 points for this game.

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Houston vs. Colorado: ATS Betting Stats and Trends

• Houston has put together a 14-14-0 ATS record so far this year.
• Colorado has covered 14 times in 28 matchups with a spread this season.
• At home, the Cougars have a better record against the spread (8-6-0) compared to their ATS record in road games (4-4-0).
• In 2025-26 against the spread, the Buffaloes have a better winning percentage at home (.588, 10-7-0 record) than on the road (.250, 2-6-0).
• Houston has eight wins against the spread in 15 conference games this year.
• Colorado has beaten the spread eight times in 15 Big 12 games.

Houston vs. Colorado: Moneyline Betting Stats

• Houston has won in 19, or 82.6%, of the 23 contests it has been named as the moneyline favorite in this year.
• The Cougars have yet to lose in four games when named as moneyline favorite of -4545 or better.
• Colorado has gone 4-9 in games it was the underdog on the moneyline (winning 30.8% of those games).
• The Buffaloes have never played a game this season with moneyline odds of +1600 or longer.
• Oddsmakers have implied with the moneyline set for this matchup that Houston has a 97.8% chance of pulling out a win.

Houston vs. Colorado Head-to-Head Comparison

• Houston's +402 scoring differential (outscoring opponents by 14.3 points per game) is a result of scoring 76.6 points per game (159th in college basketball) while giving up 62.3 per contest (second in college basketball).
• Houston's leading scorer, Kingston Flemings, is 175th in the country scoring 16.6 points per game.
• Colorado is outscoring opponents by 2.2 points per game, with a +62 scoring differential overall. It puts up 80.1 points per game (88th in college basketball) and allows 77.9 per outing (290th in college basketball).
• Isaiah Johnson leads Colorado, scoring 16.3 points per game (193rd in college basketball).
• The Cougars prevail in the rebound battle by an average of 3.9 boards. They are grabbing 32.9 rebounds per game (125th in college basketball) compared to their opponents' 29 per outing.
• Chris Cenac Jr. tops the Cougars with 7.8 rebounds per game (86th in college basketball action).
• The Buffaloes average 31.7 rebounds per game (204th in college basketball), compared to the 31.3 of their opponents.
• Bangot Dak tops the team with 6.5 rebounds per game (221st in college basketball).
• Houston's 102.3 points per 100 possessions on offense rank 77th in college basketball, and the 83.1 points it allows per 100 possessions rank fifth in college basketball.
• The Buffaloes record 101.3 points per 100 possessions (93rd in college basketball), while allowing 98.5 points per 100 possessions (276th in college basketball).

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