Top 25 College Basketball Picks & Predictions Today - March 21

There are eight games on Saturday's slate that involve teams ranked in the Top 25 in the AP Poll, highlighted by a game that has No. 15 Nebraska squaring off against No. 16 Vanderbilt (at 8:45 p.m. ET). In the article below, we offer our picks and predictions for each matchup.

Searching for an edge in March Madness? We analyze the betting odds for all the important matchups below.

Michigan vs. Saint Louis

• Matchup: Saint Louis Billikens vs. No. 3 Michigan Wolverines
• Projected Winner: Michigan (70.01% win probability)
• Spread: Michigan (-12.5)
• Time: 12:10 p.m. ET
• Date: March 21
• TV Channel: CBS

Bet on Michigan vs. Saint Louis with FanDuel Sportsbook.

Michigan State vs. Louisville

• Matchup: No. 23 Louisville Cardinals vs. No. 11 Michigan State Spartans
• Projected Winner: Michigan State (63.75% win probability)
• Spread: Michigan State (-5.5)
• Time: 2:48 p.m. ET
• Date: March 21
• TV Channel: CBS

Bet on Michigan State vs. Louisville with FanDuel Sportsbook.

Duke vs. TCU

• Matchup: TCU Horned Frogs vs. No. 1 Duke Blue Devils
• Projected Winner: Duke (76.75% win probability)
• Spread: Duke (-11.5)
• Time: 5:25 p.m. ET
• Date: March 21
• TV Channel: CBS

Bet on Duke vs. TCU with FanDuel Sportsbook.

Houston vs. Texas A&M

• Matchup: Texas A&M Aggies vs. No. 5 Houston Cougars
• Projected Winner: Houston (75.97% win probability)
• Spread: Houston (-10.5)
• Time: 6:10 p.m. ET
• Date: March 21
• TV Channel: TNT

Bet on Houston vs. Texas A&M with FanDuel Sportsbook.

Gonzaga vs. Texas

• Matchup: Texas Longhorns vs. No. 12 Gonzaga Bulldogs
• Projected Winner: Gonzaga (70.71% win probability)
• Spread: Gonzaga (-6.5)
• Time: 7:10 p.m. ET
• Date: March 21
• TV Channel: TBS

Bet on Gonzaga vs. Texas with FanDuel Sportsbook.

Illinois vs. VCU

• Matchup: VCU Rams vs. No. 13 Illinois Fighting Illini
• Projected Winner: Illinois (63.37% win probability)
• Time: 8 p.m. ET
• Date: March 22
• TV Channel: CBS

Bet on Illinois vs. VCU with FanDuel Sportsbook.

Nebraska vs. Vanderbilt

• Matchup: No. 16 Vanderbilt Commodores vs. No. 15 Nebraska Cornhuskers
• Projected Winner: Nebraska (51.84% win probability)
• Spread: Vanderbilt (-1.5)
• Time: 8:45 p.m. ET
• Date: March 22
• TV Channel: TNT

Bet on Nebraska vs. Vanderbilt with FanDuel Sportsbook.

Arkansas vs. High Point

• Matchup: High Point Panthers vs. No. 14 Arkansas Razorbacks
• Projected Winner: Arkansas (66.37% win probability)
• Spread: Arkansas (-11.5)
• Time: 9:45 p.m. ET
• Date: March 22
• TV Channel: TBS

Bet on Arkansas vs. High Point with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

For more college basketball betting insights, check out FanDuel Research's college basketball home page.

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