Michigan vs Saint Louis College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 1 seed Michigan Wolverines (32-3) try to secure a place in the Sweet 16 in an NCAA Tournament Round of 32 matchup against the No. 9 seed Saint Louis Billikens (29-5) on Saturday at KeyBank Center, starting at 12:10 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Michigan vs. Saint Louis Game Info and Odds

• Game day: Saturday, March 21, 2026
• Game time: 12:10 p.m. ET
• TV channel: CBS
• Location: Buffalo, New York
• Arena: KeyBank Center

Michigan vs. Saint Louis Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Michigan win (70%)

If you plan to place a wager on Michigan-Saint Louis matchup (in which Michigan is a 12.5-point favorite and the total has been set at 161.5 points), below are some betting insights and trends for Saturday's game.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Michigan vs. Saint Louis: ATS Betting Stats and Trends

• Michigan has put together a 15-20-0 record against the spread this season.
• Saint Louis has won 18 games against the spread this season, while failing to cover 15 times.
• The Wolverines own a better record against the spread at home (8-7-0) than they do on the road (4-7-0).
• The Billikens have performed better against the spread at home (13-5-0) than on the road (4-6-0) this year.

Michigan vs. Saint Louis: Moneyline Betting Stats

• Michigan has won in 30, or 90.9%, of the 33 contests it has been named as the moneyline favorite in this year.
• This year, the Wolverines have won 20 of 21 games when listed as at least -800 or better on the moneyline.
• Saint Louis has been the moneyline underdog just two other times so far this season, and it won both games.
• The Billikens have not played a game this season with moneyline odds of +540 or longer.
• Michigan has an implied victory probability of 88.9% according to the moneyline set by sportsbooks for this matchup.

Michigan vs. Saint Louis Head-to-Head Comparison

• Michigan has a +620 scoring differential, topping opponents by 17.7 points per game. It is putting up 87.2 points per game to rank 11th in college basketball and is allowing 69.5 per outing to rank 60th in college basketball.
• Michigan's leading scorer, Yaxel Lendeborg, is 357th in the country scoring 14.4 points per game.
• Saint Louis is outscoring opponents by 18 points per game, with a +610 scoring differential overall. It puts up 87.7 points per game (eighth in college basketball) and allows 69.7 per outing (66th in college basketball).
• Robbie Avila paces Saint Louis, averaging 12.9 points per game (565th in college basketball).
• The Wolverines pull down 36.6 rebounds per game (19th in college basketball) while allowing 26.9 per contest to their opponents. They outrebound opponents by 9.7 boards per game.
• Morez Johnson Jr. averages 7.3 rebounds per game (ranking 126th in college basketball) to lead the Wolverines.
• The Billikens come out on top in the rebound battle by an average of 7.5 boards. They are recording 36.9 rebounds per game (14th in college basketball) compared to their opponents' 29.4.
• Dion Brown leads the team with 5.5 rebounds per game (421st in college basketball).
• Michigan ranks 12th in college basketball by averaging 108.2 points per 100 possessions on offense, and defensively is 14th in college basketball, allowing 86.3 points per 100 possessions.
• The Billikens average 108.6 points per 100 possessions on offense (11th in college basketball), and give up 86.4 points per 100 possessions (18th in college basketball).

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!