Illinois vs VCU College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 3 seed Illinois Fighting Illini (25-8) take to the court against the No. 11 seed VCU Rams (28-7) with a Sweet 16 berth in the South Region of the bracket on the line on Saturday at Bon Secours Wellness Arena at 7:50 p.m. ET.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Illinois vs. VCU Game Info and Odds

• Game day: Saturday, March 21, 2026
• Game time: 7:50 p.m. ET
• TV channel: CBS
• Location: Greenville, South Carolina
• Arena: Bon Secours Wellness Arena

Illinois vs. VCU Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Illinois win (62.1%)

Illinois is a 10.5-point favorite against VCU on Saturday and the over/under has been set at 150.5 points. Here's a few betting trends and insights to help you make an informed wager on the game.

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Illinois vs. VCU: ATS Betting Stats and Trends

• Illinois has compiled a 19-14-0 ATS record so far this year.
• VCU has compiled a 19-16-0 ATS record so far this year.
• VCU covers the spread when it is a 10.5-point underdog or more 100% of the time. That's more often than Illinois covers as a favorite of 10.5 or more (52.9%).
• The Fighting Illini have a worse record against the spread at home (10-7-0) than they do in away games (6-4-0).
• The Rams have been better against the spread away (6-4-0) than at home (7-10-0) this season.

Illinois vs. VCU: Moneyline Betting Stats

• Illinois has won in 18, or 78.3%, of the 23 contests it has been named as the moneyline favorite in this year.
• The Fighting Illini have a win-loss record of 11-2 when favored by -649 or better by bookmakers this year.
• VCU has gone 2-4 in games it was the underdog on the moneyline (winning 33.3% of those games).
• The Rams have played as a moneyline underdog of +460 or longer in only one game this season, which they lost.
• Oddsmakers have implied with the moneyline set for this matchup that Illinois has a 86.6% chance of pulling out a win.

Illinois vs. VCU Head-to-Head Comparison

• Illinois' +501 scoring differential (outscoring opponents by 15.2 points per game) is a result of scoring 85 points per game (17th in college basketball) while allowing 69.8 per outing (67th in college basketball).
• Illinois' leading scorer, Keaton Wagler, ranks 98th in the nation scoring 17.9 points per game.
• VCU puts up 81.6 points per game (55th in college basketball) while giving up 71.7 per outing (116th in college basketball). It has a +347 scoring differential and outscores opponents by 9.9 points per game.
• Terrence Hill Jr.'s 14.9 points per game leads VCU and ranks 310th in the nation.
• The Fighting Illini win the rebound battle by 9.9 boards on average. They record 37.8 rebounds per game, which ranks sixth in college basketball, while their opponents pull down 27.9 per outing.
• David Mirkovic tops the team with eight rebounds per game (81st in college basketball play).
• The Rams rank 93rd in the country at 33.6 rebounds per game. That's 3.2 more than the 30.4 their opponents average.
• Lazar Djokovic tops the team with 5.4 rebounds per game (452nd in college basketball).
• Illinois' 109.9 points per 100 possessions on offense rank fourth in college basketball, and the 90.3 points it allows per 100 possessions rank 54th in college basketball.
• The Rams put up 104.1 points per 100 possessions (41st in college basketball), while allowing 91.5 points per 100 possessions (80th in college basketball).

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