Vanderbilt vs Nebraska College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 4 seed Nebraska Cornhuskers (27-6) are ready for their second-round NCAA Tournament matchup against the No. 5 seed Vanderbilt Commodores (27-8) on Saturday at 8:45 p.m. ET. The winner advances to the Sweet 16 in the South Region bracket.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Vanderbilt vs. Nebraska Game Info and Odds

• Game day: Saturday, March 21, 2026
• Game time: 8:45 p.m. ET
• TV channel: TNT
• Location: Oklahoma City, Oklahoma
• Arena: Paycom Center

Vanderbilt vs. Nebraska Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Nebraska win (51.8%)

See the betting trends and insights below before making a bet on Saturday's Vanderbilt-Nebraska spread (Vanderbilt -1.5) or over/under (146.5 points).

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Vanderbilt vs. Nebraska: ATS Betting Stats and Trends

• Vanderbilt has put together an 18-17-0 record against the spread this season.
• Nebraska has compiled an 18-15-0 ATS record so far this year.
• Vanderbilt (14-15) covers a lower percentage of games when it is favored by 1.5 points or more this season (48.3%) than Nebraska (4-3) does as a 1.5+-point underdog (57.1%).
• The Commodores have covered the spread in the same percentage of games at home as away games (50%). They have covered eight times in 16 games at home and six times in 12 games when playing on the road.
• This year, the Cornhuskers are 8-10-0 at home against the spread (.444 winning percentage). On the road, they are 7-3-0 ATS (.700).

Vanderbilt vs. Nebraska: Moneyline Betting Stats

• Vanderbilt has won in 19, or 79.2%, of the 24 contests it has been named as the moneyline favorite in this year.
• The Commodores have a win-loss record of 19-5 when favored by -130 or better by sportsbooks this year.
• Nebraska has won three of the six games it was the moneyline underdog this season (50%).
• When they have played as a moneyline underdog with odds of +108 or longer, the Cornhuskers have a 3-2 record (winning 60% of their games).
• Vanderbilt has an implied victory probability of 56.5% according to the moneyline set by oddsmakers for this matchup.

Vanderbilt vs. Nebraska Head-to-Head Comparison

• Vanderbilt averages 86.1 points per game (14th in college basketball) while giving up 75.0 per contest (216th in college basketball). It has a +389 scoring differential overall and outscores opponents by 11.1 points per game.
• Tyler is 50th in college basketball with a team-leading 19.3 points per game.
• Nebraska is outscoring opponents by 11.6 points per game, with a +383 scoring differential overall. It puts up 77.2 points per game (144th in college basketball) and allows 65.6 per outing (15th in college basketball).
• Nebraska's leading scorer, Pryce Sandfort, is 94th in the nation, putting up 18.0 points per game.
• The 32.3 rebounds per game the Commodores average rank 155th in the country. Their opponents pull down 31.3 per outing.
• Devin is 198th in college basketball play with 6.7 rebounds per game to lead the Commodores.
• The 32.6 rebounds per game the Cornhuskers accumulate rank 138th in college basketball, 1.1 more than the 31.5 their opponents collect.
• Rienk Mast paces the Cornhuskers with 5.8 rebounds per game (329th in college basketball).
• Vanderbilt's 107.9 points per 100 possessions on offense rank 13th in college basketball, and the 94.0 points it allows per 100 possessions rank 139th in college basketball.
• The Cornhuskers average 102.5 points per 100 possessions on offense (68th in college basketball), and give up 87.1 points per 100 possessions (26th in college basketball).

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