Vanderbilt vs Nebraska College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 5 seed Vanderbilt Commodores (27-8) attempt to punch their ticket to the Sweet 16 in an NCAA Tournament second-round matchup against the No. 4 seed Nebraska Cornhuskers (27-6) on Saturday at Paycom Center, starting at 8:45 p.m. ET.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Vanderbilt vs. Nebraska Game Info and Odds

• Game day: Saturday, March 21, 2026
• Game time: 8:45 p.m. ET
• TV channel: TNT
• Location: Oklahoma City, Oklahoma
• Arena: Paycom Center

Vanderbilt vs. Nebraska Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Nebraska win (51.1%)

Before you wager on Saturday's Vanderbilt-Nebraska spread (Vanderbilt -1.5) or total (146.5 points), see the betting trends and insights below.

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Vanderbilt vs. Nebraska: ATS Betting Stats and Trends

• Vanderbilt has covered 18 times in 35 chances against the spread this season.
• Nebraska is 18-15-0 ATS this year.
• As a 1.5-point underdog or more in 2025-26, Nebraska is 4-3 against the spread compared to the 14-15 ATS record Vanderbilt racks up as a 1.5-point favorite.
• The Commodores have the same winning percentage against the spread when playing at home (.500) as they do in road games.
• The Cornhuskers have been better against the spread away (7-3-0) than at home (8-10-0) this year.

Vanderbilt vs. Nebraska: Moneyline Betting Stats

• Vanderbilt has won in 19, or 79.2%, of the 24 contests it has been named as the moneyline favorite in this year.
• This year, the Commodores have won 19 of 24 games when listed as at least -128 or better on the moneyline.
• Nebraska has been the moneyline underdog six total times this season. Nebraska has finished 3-3 in those games.
• When playing as a moneyline underdog with odds of +106 or longer, the Cornhuskers have gone 3-2 (60%).
• Vanderbilt has an implied victory probability of 56.1% according to the moneyline set by sportsbooks for this matchup.

Vanderbilt vs. Nebraska Head-to-Head Comparison

• Vanderbilt is outscoring opponents by 11.1 points per game with a +389 scoring differential overall. It puts up 86.1 points per game (14th in college basketball) and allows 75.0 per outing (216th in college basketball).
• Tyler ranks 50th in the country with a team-high 19.3 points per game.
• Nebraska puts up 77.2 points per game (144th in college basketball) while giving up 65.6 per contest (15th in college basketball). It has a +383 scoring differential and outscores opponents by 11.6 points per game.
• Pryce Sandfort's 18.0 points per game paces Nebraska and ranks 94th in college basketball.
• The Commodores grab 32.3 rebounds per game (155th in college basketball) compared to the 31.3 of their opponents.
• Devin is 198th in college basketball play with 6.7 rebounds per game to lead the Commodores.
• The Cornhuskers rank 138th in the country at 32.6 rebounds per game. That's 1.1 more than the 31.5 their opponents average.
• Rienk Mast averages 5.8 rebounds per game (329th in college basketball) to lead the Cornhuskers.
• Vanderbilt ranks 13th in college basketball with 107.9 points scored per 100 possessions, and 139th in college basketball defensively with 94.0 points conceded per 100 possessions.
• The Cornhuskers average 102.5 points per 100 possessions on offense (68th in college basketball), and give up 87.1 points per 100 possessions (27th in college basketball).

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