Duke vs TCU College Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 1 seed Duke Blue Devils (33-2) and the No. 9 seed TCU Horned Frogs (23-11) will meet in the NCAA Tournament with a ticket to the Sweet 16 of the East Region bracket up for grabs on Saturday at Bon Secours Wellness Arena, beginning at 5:15 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. TCU Game Info and Odds

• Game day: Saturday, March 21, 2026
• Game time: 5:15 p.m. ET
• TV channel: CBS
• Location: Greenville, South Carolina
• Arena: Bon Secours Wellness Arena

Duke vs. TCU Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (76.8%)

Duke is an 11.5-point favorite over TCU on Saturday and the over/under has been set at 139.5 points. Here are a few betting trends and insights to help you make an informed wager on the outing.

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Duke vs. TCU: ATS Betting Stats and Trends

• Duke has covered 18 times in 35 games with a spread this season.
• TCU has compiled a 20-14-0 record against the spread this season.
• As an 11.5-point underdog or more in 2025-26, TCU is 2-0 against the spread compared to the 8-13 ATS record Duke racks up as an 11.5-point favorite.
• The Blue Devils have done a better job covering the spread on the road (8-3-0) than they have at home (6-9-0).
• The Horned Frogs' winning percentage against the spread at home is .474 (9-10-0). Away, it is .667 (6-3-0).

Duke vs. TCU: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 28 games this year and has walked away with the win 26 times (92.9%) in those games.
• The Blue Devils have not lost in 14 games this year when favored by -901 or better on the moneyline.
• TCU has won 50% of the games this season it was the moneyline underdog (6-6).
• The Horned Frogs have played as a moneyline underdog of +590 or longer in just one game this season, which they lost.
• The moneyline set for this matchup implies Duke has a 90% chance of walking away with the win.

Duke vs. TCU Head-to-Head Comparison

• Last season, Duke was 11th-best in the country on offense (83.2 points scored per game) and seventh-best on defense (62.8 points conceded).
• Last year, Duke was 24th-best in the nation in rebounds (35.6 per game) and 12th-best in rebounds conceded (27.3).
• With 16.9 assists per game, Duke was 17th-best in college basketball last year.
• Duke was the ninth-best squad in college basketball in turnovers per game (8.9) and 265th in turnovers forced (10.4) last year.
• On offense, TCU scored 67.6 points per game (326th-ranked in college basketball) last year. It allowed 68.7 points per contest at the other end (74th-ranked).
• TCU ranked 221st in the nation with 31.2 rebounds per game. Meanwhile, it ranked 164th with 30.9 rebounds allowed per contest.
• Last year TCU ranked 279th in college basketball in assists, averaging 12.2 per game.
• TCU committed 10.9 turnovers per game (150th-ranked in college basketball). It forced 12.1 turnovers per contest (100th-ranked).

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