NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 4

The matchups in a Week 4 NFL lineup that shouldn't be missed include the Baltimore Ravens taking on the Kansas City Chiefs at GEHA Field at Arrowhead Stadium.

If you're looking for additional betting info for Week 4 in the NFL, we have you covered with betting odds for each of the big matchups.

Cardinals vs. Seahawks

The Seattle Seahawks (2-1) and Jaxon Smith-Njigba, one of the league's top receivers, should have a big day through the air on Thursday, as the Arizona Cardinals (2-1) own the 30th-ranked pass defense in the NFL. The two teams will match up at 8:15 p.m. ET on Sept. 25.

• Game Preview: Seattle Seahawks at Arizona Cardinals
• Projected Favorite: Cardinals (55.65% win probability)
• Spread: Seattle (-1.5)
• Total: 43.5 -- Over: (-102) | Under: (-120)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Arizona vs. Seattle with FanDuel Sportsbook.

Steelers vs. Vikings

The Minnesota Vikings (2-1) and the Pittsburgh Steelers (2-1), who both took home a win in their last game, will go head to head at 9:30 a.m. ET on Sunday, Sept. 28. In their previous games, the Vikings won 48-10 versus the Bengals, and the Steelers defeated the Patriots 21-14.

• Game Preview: Minnesota Vikings vs. Pittsburgh Steelers
• Projected Favorite: Vikings (57.56% win probability)
• Spread: Minnesota (-2.5)
• Total: 40.5 -- Over: (-115) | Under: (-105)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Pittsburgh vs. Minnesota with FanDuel Sportsbook.

Patriots vs. Panthers

On Sunday, Sept. 28 at 1 p.m. ET, the New England Patriots (1-2) will attempt to rebound from their recent 21-14 loss to the Steelers when they take on the Carolina Panthers (1-2) at Gillette Stadium. The Panthers won their last tilt 30-0 against the Falcons.

• Game Preview: Carolina Panthers at New England Patriots
• Projected Favorite: Patriots (67.03% win probability)
• Spread: New England (-5.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New England vs. Carolina with FanDuel Sportsbook.

Lions vs. Browns

Amon-Ra St. Brown and the Detroit Lions (2-1) will get a tough test when they match up with the Cleveland Browns (1-2), who own the league's fourth-best pass defense, on Sunday, Sept. 28 at 1 p.m. ET. St. Brown is seventh-best in the league in receiving yards.

• Game Preview: Cleveland Browns at Detroit Lions
• Projected Favorite: Lions (86.64% win probability)
• Spread: Detroit (-8.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. Cleveland with FanDuel Sportsbook.

Bills vs. Saints

The Buffalo Bills (3-0) should light up the scoreboard on Sunday, Sept. 28 at 1 p.m. ET, when they host the New Orleans Saints (0-3) at Highmark Stadium. While the Bills are putting up 34.0 points per game (fourth in NFL), the Saints are surrendering 15.7 points per contest (29th in league).

• Game Preview: New Orleans Saints at Buffalo Bills
• Projected Favorite: Bills (88.12% win probability)
• Spread: Buffalo (-16.5)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Buffalo vs. New Orleans with FanDuel Sportsbook.

Buccaneers vs. Eagles

On Sunday at 1 p.m. ET, a pair of the best offensive performers in football will be featured when QB Jalen Hurts and the Philadelphia Eagles (3-0) visit pass-catcher Emeka Egbuka and the Tampa Bay Buccaneers (3-0).

• Game Preview: Philadelphia Eagles at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (56.11% win probability)
• Spread: Philadelphia (-3.5)
• Total: 44.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Philadelphia with FanDuel Sportsbook.

Texans vs. Titans

The Tennessee Titans (0-3) are in action on Sunday at 1 p.m. ET at NRG Stadium versus the Houston Texans (0-3).

• Game Preview: Tennessee Titans at Houston Texans
• Projected Favorite: Texans (79.89% win probability)
• Spread: Houston (-7.5)
• Total: 38.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Tennessee with FanDuel Sportsbook.

Giants vs. Chargers

On Sunday at 1 p.m. ET, two outstanding pass-catchers will be on display when Quentin Johnston and the Los Angeles Chargers (3-0) visit Malik Nabers and the New York Giants (0-3).

• Game Preview: Los Angeles Chargers at New York Giants
• Projected Favorite: Chargers (75.94% win probability)
• Spread: Los Angeles (-6.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Los Angeles with FanDuel Sportsbook.

Falcons vs. Commanders

When the Washington Commanders (2-1) and the Atlanta Falcons (1-2) meet on Sunday, Sept. 28 at 1 p.m. ET, the Commanders will be looking to follow up their recent victory over the Raiders with another win, and the Falcons will be trying to bounce back from a loss to the Panthers.

• Game Preview: Washington Commanders at Atlanta Falcons
• Projected Favorite: Commanders (60.16% win probability)
• Spread: Washington (-1.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Atlanta vs. Washington with FanDuel Sportsbook.

Rams vs. Colts

After going down 33-26 to the Eagles in their previous contest, the Los Angeles Rams (2-1) will host the Indianapolis Colts (3-0), who are coming off a 41-20 win over the Titans. The game is set for 4:05 p.m. ET on Sunday, Sept. 28.

• Game Preview: Indianapolis Colts at Los Angeles Rams
• Projected Favorite: Rams (56.09% win probability)
• Spread: Los Angeles (-3.5)
• Total: 49.5 -- Over: (-104) | Under: (-118)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Indianapolis with FanDuel Sportsbook.

49ers vs. Jaguars

On Sunday at 4:05 p.m. ET, a pair of outstanding running backs will be featured when Christian McCaffrey and the San Francisco 49ers (3-0) host Travis Etienne and the Jacksonville Jaguars (2-1).

• Game Preview: Jacksonville Jaguars at San Francisco 49ers
• Projected Favorite: 49ers (55.89% win probability)
• Spread: San Francisco (-3.5)
• Total: 46.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Jacksonville with FanDuel Sportsbook.

Chiefs vs. Ravens

The Baltimore Ravens (1-2), who were defeated by the Lions in their last tilt, visit the Kansas City Chiefs (1-2) at GEHA Field at Arrowhead Stadium on Sept. 28 at 4:25 p.m. ET. The Chiefs took down the Giants in their last game.

• Game Preview: Baltimore Ravens at Kansas City Chiefs
• Projected Favorite: Ravens (62.17% win probability)
• Spread: Baltimore (-2.5)
• Total: 48.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Kansas City vs. Baltimore with FanDuel Sportsbook.

Raiders vs. Bears

Caleb Williams will lead the Chicago Bears (1-2) into their matchup versus the Las Vegas Raiders (1-2) at Allegiant Stadium on Sunday at 4:25 p.m. ET.

• Game Preview: Chicago Bears at Las Vegas Raiders
• Projected Favorite: Raiders (50.54% win probability)
• Spread: Las Vegas (-1.5)
• Total: 47.5 -- Over: (-118) | Under: (-104)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Chicago with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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