49ers vs Jaguars Prediction, Odds, Picks, Best Bets for NFL Week 4

The San Francisco 49ers versus the Jacksonville Jaguars is on the NFL schedule for Sunday.

Get the latest NFL odds ahead of this game on FanDuel Sportsbook.

49ers vs Jaguars Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (55.9%)

49ers vs Jaguars Point Spread

The 49ers are 3.5-point favorites against the Jaguars. The 49ers are -102 to cover the spread, while the Jaguars are -120 to cover as a 3.5-point underdog.

49ers vs Jaguars Over/Under

49ers versus Jaguars on Sept. 28 has an over/under of 46.5 points, with the over -115 and the under -105.

49ers vs Jaguars Moneyline

Jacksonville is the underdog, +142 on the moneyline, while San Francisco is a -168 favorite at home.

49ers vs Jaguars Betting Trends

• San Francisco has posted two wins against the spread this season.
• The 49ers have had one game (out of three) hit the over this year.
• The Jaguars have won twice against the spread this season.
• Jacksonville doesn't have a win ATS (0-1) as a 3.5-point underdog or greater this season.
• One of the Jaguars' three games has hit the over.

Check out even more in-depth 49ers vs. Jaguars analysis on FanDuel Research.

49ers vs Jaguars Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-168) | JAX: (+142)
• Spread: SF: -3.5 (-102) | JAX: +3.5 (-120)
• Total: 46.5 -- Over: (-115) | Under: (-105)

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