Rams vs Colts Prediction, Odds, Picks, Best Bets for NFL Week 4

Sunday's slate in the NFL includes a matchup between the Los Angeles Rams and the Indianapolis Colts.

Get the latest NFL odds ahead of this game on FanDuel Sportsbook.

Rams vs Colts Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Rams win (56.1%)

Rams vs Colts Point Spread

The Rams are 3.5-point favorites against the Colts. The Rams are -112 to cover the spread, while the Colts are -108 to cover as a 3.5-point underdog.

Rams vs Colts Over/Under

A combined point total of 49.5 has been set for Rams-Colts on Sept. 28, with the over at -104 and the under at -118.

Rams vs Colts Moneyline

The Rams vs Colts moneyline has the Rams as a -186 favorite, while the Colts are a +156 underdog on the road.

Rams vs Colts Betting Trends

• Los Angeles has two wins against the spread this year.
• The Rams are unbeaten ATS (1-0) as a 3.5-point favorite or greater this year.
• Two of the Rams' three games have gone over the point total.
• The Colts haven't lost a game against the spread this season.
• Two Colts games (out of three) have gone over the point total this year.

Check out even more in-depth Rams vs. Colts analysis on FanDuel Research.

Rams vs Colts Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAR: (-186) | IND: (+156)
• Spread: LAR: -3.5 (-112) | IND: +3.5 (-108)
• Total: 49.5 -- Over: (-104) | Under: (-118)

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