Bills vs Saints Prediction, Odds, Picks, Best Bets for NFL Week 4

In NFL action on Sunday, the Buffalo Bills face the New Orleans Saints.

We've got you covered, in terms of the vital information regarding NFL betting lines, before you make your wager on FanDuel Sportsbook.

Bills vs Saints Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (88.1%)

Bills vs Saints Point Spread

The Bills are 16.5-point favorites against the Saints. The Bills are -110 to cover the spread, while the Saints are -110 to cover as a 16.5-point underdog.

Bills vs Saints Over/Under

The over/under for Bills-Saints on Sept. 28 is 48.5. The over is -105, and the under is -115.

Bills vs Saints Moneyline

Buffalo is the favorite, -1786 on the moneyline, while New Orleans is a +980 underdog on the road.

Bills vs Saints Betting Trends

• Buffalo has posted two wins against the spread this year.
• Two Bills games (out of three) have gone over the point total this season.
• The Saints have no wins against the spread this season.
• Two of the Saints' three games in 2025 have hit the over.

Check out even more in-depth Bills vs. Saints analysis on FanDuel Research.

Bills vs Saints Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-1786) | NO: (+980)
• Spread: BUF: -16.5 (-110) | NO: +16.5 (-110)
• Total: 48.5 -- Over: (-105) | Under: (-115)

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