Bills vs Saints Prediction, Odds, Picks, Best Bets for NFL Week 4

The NFL schedule on Sunday includes the Buffalo Bills taking on the New Orleans Saints.

Before you place your bet on this game at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

Bills vs Saints Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (86.8%)

Bills vs Saints Point Spread

The Bills are 14.5-point favorites against the Saints. The Bills are -115 to cover the spread, while the Saints are -105 to cover as a 14.5-point underdog.

Bills vs Saints Over/Under

A total of 48.5 points has been set for the Bills-Saints matchup on Sept. 28, with the over available at -104 and the under at -118.

Bills vs Saints Moneyline

New Orleans is a +870 underdog on the moneyline, while Buffalo is a -1493 favorite on the road.

Bills vs Saints Betting Trends

• Buffalo has two wins against the spread this season.
• Two Bills games (out of three) have hit the over this year.
• The Saints are winless against the spread this season.
• Two of the Saints' three games in 2025 have gone over the point total.

Check out even more in-depth Bills vs. Saints analysis on FanDuel Research.

Bills vs Saints Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-1493) | NO: (+870)
• Spread: BUF: -14.5 (-115) | NO: +14.5 (-105)
• Total: 48.5 -- Over: (-104) | Under: (-118)

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