Chargers vs Giants Prediction, Odds, Picks, Best Bets for NFL Week 4

Sunday's slate in the NFL includes a matchup between the Los Angeles Chargers and the New York Giants.

Get the latest NFL odds ahead of this game on FanDuel Sportsbook.

Chargers vs Giants Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Chargers win (75.9%)

Chargers vs Giants Point Spread

The Chargers are 6.5-point favorites against the Giants. The Chargers are -105 to cover the spread, while the Giants are -115 to cover as a 6.5-point underdog.

Chargers vs Giants Over/Under

The over/under for the Chargers versus Giants game on Sept. 28 has been set at 43.5, with -110 odds on the over and -110 odds on the under.

Chargers vs Giants Moneyline

Looking at the moneyline for Giants-Chargers, New York is the underdog at +235, and Los Angeles is -290 playing on the road.

Chargers vs Giants Betting Trends

• Los Angeles has won twice against the spread this year.
• The Chargers have had one game (out of three) go over the total this year.
• The Giants have one win against the spread this season.
• New York doesn't have a win ATS (0-1) as a 6.5-point underdog or more this year.
• One of the Giants' three games has gone over the point total.

Check out even more in-depth Chargers vs. Giants analysis on FanDuel Research.

Chargers vs Giants Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAC: (-290) | NYG: (+235)
• Spread: LAC: -6.5 (-105) | NYG: +6.5 (-115)
• Total: 43.5 -- Over: (-110) | Under: (-110)

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