NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 16

The NFL slate in Week 16 is sure to please. The matchups include the Los Angeles Rams taking on the Seattle Seahawks at Lumen Field.

Here's everything you need to know in terms of the betting odds for Week 16 in the NFL.

Seahawks vs. Rams

Two of the top offensive performers in football will be featured when wide receiver Jaxon Smith-Njigba and the Seattle Seahawks (11-3) host running back Kyren Williams and the Los Angeles Rams (11-3) on Thursday, December 18, 2025.

• Game Preview: Los Angeles Rams at Seattle Seahawks
• Projected Favorite: Seahawks (61.88% win probability)
• Spread: Seattle (-1.5)
• Total: 42.5 -- Over: (-106) | Under: (-114)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Seattle vs. Los Angeles with FanDuel Sportsbook.

Commanders vs. Eagles

At Northwest Stadium on Saturday, the Philadelphia Eagles (9-5) meet the Washington Commanders (4-10).

• Game Preview: Philadelphia Eagles at Washington Commanders
• Projected Favorite: Eagles (69.87% win probability)
• Spread: Philadelphia (-7)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 5 p.m. ET
• Channel: FOX

Bet on Washington vs. Philadelphia with FanDuel Sportsbook.

Bears vs. Packers

The Chicago Bears (10-4) are scheduled to do battle against the Green Bay Packers (9-4-1) at Soldier Field on Saturday, Dec. 20 at 8:20 p.m. ET. In their previous tilts, the Bears took down the Browns 31-3, and the Packers lost 34-26 to the Broncos.

• Game Preview: Green Bay Packers at Chicago Bears
• Projected Favorite: Bears (54.92% win probability)
• Spread: Chicago (-1.5)
• Total: 45.5 -- Over: (-102) | Under: (-120)
• Time: 8:20 p.m. ET
• Channel: FOX

Bet on Chicago vs. Green Bay with FanDuel Sportsbook.

Browns vs. Bills

At Huntington Bank Field on Sunday, James Cook and the Buffalo Bills (10-4) play Harold Fannin and the Cleveland Browns (3-11) in a matchup between a pair of the biggest stars in football on offense, beginning at 1 p.m. ET.

• Game Preview: Buffalo Bills at Cleveland Browns
• Projected Favorite: Bills (69.11% win probability)
• Spread: Buffalo (-10.5)
• Total: 40.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cleveland vs. Buffalo with FanDuel Sportsbook.

Panthers vs. Buccaneers

The Tampa Bay Buccaneers (7-7) and the Carolina Panthers (7-7), who both lost their last game, will match up at 1 p.m. ET on Sunday, Dec. 21. In their previous games, the Buccaneers lost 29-28 to the Falcons, and the Panthers were defeated by the Saints 20-17.

• Game Preview: Tampa Bay Buccaneers at Carolina Panthers
• Projected Favorite: Buccaneers (51.60% win probability)
• Spread: Tampa Bay (-3)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Tampa Bay with FanDuel Sportsbook.

Titans vs. Chiefs

The Tennessee Titans (2-12) and their 29th-ranked scoring offense (16.1 points per game) will need to be firing on all cylinders when they match up with the Kansas City Chiefs (6-8), who sport the fourth-ranked scoring defense in the NFL (19.1 points allowed per game). Kickoff is set for Sunday, Dec. 21 at 1 p.m. ET.

• Game Preview: Kansas City Chiefs at Tennessee Titans
• Projected Favorite: Chiefs (70.62% win probability)
• Spread: Kansas City (-3)
• Total: 37.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. Kansas City with FanDuel Sportsbook.

Giants vs. Vikings

The Minnesota Vikings (6-8), who grabbed a win against the Cowboys in their previous game, visit the New York Giants (2-12) at MetLife Stadium on Dec. 21 at 1 p.m. ET. The Giants were taken down by the Commanders in their last game.

• Game Preview: Minnesota Vikings at New York Giants
• Projected Favorite: Giants (52.20% win probability)
• Spread: Minnesota (-2.5)
• Total: 42.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Minnesota with FanDuel Sportsbook.

Cowboys vs. Chargers

George Pickens, who ranks third-best in the league in receiving yards, will try to lead the charge for the Dallas Cowboys (6-7-1) on Dec. 21 at 1 p.m. ET, when they host the Los Angeles Chargers (10-4) and their third-best pass D (174.4 passing yards allowed per game).

• Game Preview: Los Angeles Chargers at Dallas Cowboys
• Projected Favorite: Cowboys (53.89% win probability)
• Spread: Dallas (-1.5)
• Total: 50.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Dallas vs. Los Angeles with FanDuel Sportsbook.

Dolphins vs. Bengals

The Cincinnati Bengals (4-10) and their worst run defense might have difficulty stopping the Miami Dolphins (6-8) and De'Von Achane, one of the NFL's top rushers, when the Bengals visit the Dolphins at Hard Rock Stadium on Dec. 21 at 1 p.m. ET.

• Game Preview: Cincinnati Bengals at Miami Dolphins
• Projected Favorite: Dolphins (57.64% win probability)
• Spread: Cincinnati (-4.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: NBC

Bet on Miami vs. Cincinnati with FanDuel Sportsbook.

Saints vs. Jets

The New Orleans Saints (4-10) have struggled to put up points this season, ranking 29th in the league at 16.1 points per game. But they might have success on Dec. 21 at 1 p.m. ET, when they host the New York Jets (3-11), who rank just 30th in scoring defense (19.7 points allowed per game).

• Game Preview: New York Jets at New Orleans Saints
• Projected Favorite: Saints (64.96% win probability)
• Spread: New Orleans (-6.5)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New Orleans vs. New York with FanDuel Sportsbook.

Broncos vs. Jaguars

One of the top running backs in football will be featured when Travis Etienne and the Jacksonville Jaguars (10-4) visit the Denver Broncos (12-2) on Sunday, December 21, 2025.

• Game Preview: Jacksonville Jaguars at Denver Broncos
• Projected Favorite: Broncos (59.19% win probability)
• Spread: Denver (-3.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Denver vs. Jacksonville with FanDuel Sportsbook.

Cardinals vs. Falcons

Bijan Robinson and the Atlanta Falcons (5-9) will visit Trey McBride and the Arizona Cardinals (3-11) on Sunday at 4:05 p.m. ET, in a matchup featuring two of the brightest stars in football.

• Game Preview: Atlanta Falcons at Arizona Cardinals
• Projected Favorite: Falcons (56.91% win probability)
• Spread: Atlanta (-2.5)
• Total: 48.5 -- Over: (-108) | Under: (-112)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Arizona vs. Atlanta with FanDuel Sportsbook.

Lions vs. Steelers

Amon-Ra St. Brown will lead the Detroit Lions (8-6) into their battle versus the Pittsburgh Steelers (8-6) at Ford Field on Sunday at 4:25 p.m. ET.

• Game Preview: Pittsburgh Steelers at Detroit Lions
• Projected Favorite: Lions (73.70% win probability)
• Spread: Detroit (-7)
• Total: 51.5 -- Over: (-114) | Under: (-106)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Detroit vs. Pittsburgh with FanDuel Sportsbook.

Texans vs. Raiders

A pair of excellent pass-catchers will be featured when Nico Collins and the Houston Texans (9-5) host Brock Bowers and the Las Vegas Raiders (2-12) on Sunday, December 21, 2025.

• Game Preview: Las Vegas Raiders at Houston Texans
• Projected Favorite: Texans (84.99% win probability)
• Spread: Houston (-14.5)
• Total: 38.5 -- Over: (-112) | Under: (-108)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Houston vs. Las Vegas with FanDuel Sportsbook.

Ravens vs. Patriots

Derrick Henry and the Baltimore Ravens (7-7) will get a stiff test when they match up with the New England Patriots (11-3), who own the NFL's fifth-best run defense, on Sunday, Dec. 21 at 8:20 p.m. ET. Henry ranks sixth-best in the NFL in rushing yards.

• Game Preview: New England Patriots at Baltimore Ravens
• Projected Favorite: Ravens (57.55% win probability)
• Spread: Baltimore (-3.5)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Baltimore vs. New England with FanDuel Sportsbook.

Colts vs. 49ers

When the San Francisco 49ers (10-4) and the Indianapolis Colts (8-6) square off on Monday, Dec. 22 at 8:15 p.m. ET, the 49ers will be aiming to follow up their recent victory over the Titans with another win, and the Colts will be attempting to rebound from a loss to the Seahawks.

• Game Preview: San Francisco 49ers at Indianapolis Colts
• Projected Favorite: 49ers (57.62% win probability)
• Spread: San Francisco (-5.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 8:15 p.m. ET
• Channel: ESPN

Bet on Indianapolis vs. San Francisco with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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