Buccaneers vs Panthers Prediction, Odds, Picks, Best Bets for NFL Week 16

The NFL slate on Sunday includes the Tampa Bay Buccaneers taking on the Carolina Panthers.

We've got you covered, in terms of the vital information regarding NFL betting lines, before you make your wager on FanDuel Sportsbook.

Buccaneers vs Panthers Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Buccaneers win (51.6%)

Buccaneers vs Panthers Point Spread

The Buccaneers are 3-point favorites against the Panthers. The Buccaneers are -102 to cover the spread, while the Panthers are -120 to cover as a 3-point underdog.

Buccaneers vs Panthers Over/Under

A total of 45.5 points has been set for the Buccaneers-Panthers game on Dec. 21, with the over available at -110 and the under at -110.

Buccaneers vs Panthers Moneyline

Tampa Bay is a -152 favorite on the moneyline, while Carolina is a +128 underdog at home.

Buccaneers vs Panthers Betting Trends

• Tampa Bay's record against the spread is 5-9-0.
• The Buccaneers have two wins ATS (2-4) as a 3-point favorite or greater this season.
• There have been eight Buccaneers games (out of 14) that went over the total this year.
• The Panthers are 8-6-0 against the spread this year.
• Carolina is 6-4 as 3-point or bigger underdogs in 2025.
• This season, seven of the Panthers' 14 games have gone over the point total.

Check out even more in-depth Buccaneers vs. Panthers analysis on FanDuel Research.

Buccaneers vs Panthers Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-152) | CAR: (+128)
• Spread: TB: -3 (-102) | CAR: +3 (-120)
• Total: 45.5 -- Over: (-110) | Under: (-110)

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