Bills vs Browns Prediction, Odds, Picks, Best Bets for NFL Week 16

The Buffalo Bills will face the Cleveland Browns in NFL action on Sunday.

Get the latest NFL odds ahead of this matchup on FanDuel Sportsbook.

Bills vs Browns Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (69.1%)

Bills vs Browns Point Spread

The Bills are 10.5-point favorites against the Browns. The Bills are -105 to cover the spread, while the Browns are -115 to cover as a 10.5-point underdog.

Bills vs Browns Over/Under

The Bills-Browns game on Dec. 21 has been given an over/under of 40.5 points. The over is -115 and the under is -105.

Bills vs Browns Moneyline

Buffalo is a -649 favorite on the moneyline, while Cleveland is a +480 underdog at home.

Bills vs Browns Betting Trends

• Against the spread, Buffalo is 7-7-0 this year.
• The Bills have no wins ATS (0-2) as a 10.5-point favorite or greater this year.
• There have been seven Bills games (out of 14) that went over the total this year.
• Against the spread, the Browns are 5-9-0 this year.
• Cleveland is winless ATS (0-1) when playing as at least 10.5-point underdogs this season.
• The Browns have played 14 games this year, and seven of them have gone over the total.

Check out even more in-depth Bills vs. Browns analysis on FanDuel Research.

Bills vs Browns Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-649) | CLE: (+480)
• Spread: BUF: -10.5 (-105) | CLE: +10.5 (-115)
• Total: 40.5 -- Over: (-115) | Under: (-105)

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