Bills vs Browns Prediction, Odds, Picks, Best Bets for NFL Week 16

The Buffalo Bills versus the Cleveland Browns is on the NFL schedule for Sunday.

All the info you need is below, in order to make a smart wager on this matchup at FanDuel Sportsbook.

Bills vs Browns Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Bills win (69.1%)

Bills vs Browns Point Spread

The Bills are 10.5-point favorites against the Browns. The Bills are +100 to cover the spread, while the Browns are -122 to cover as a 10.5-point underdog.

Bills vs Browns Over/Under

A combined point total of 42.5 has been set for Bills-Browns on Dec. 21, with the over at -108 and the under at -112.

Bills vs Browns Moneyline

Cleveland is a +480 underdog on the moneyline, while Buffalo is a -649 favorite at home.

Bills vs Browns Betting Trends

• Buffalo has seven wins in 14 games against the spread this season.
• The Bills have no wins ATS (0-2) as a 10.5-point favorite or greater this year.
• Out of 14 Bills games so far this year, seven have hit the over.
• The Browns' record against the spread is 5-9-0.
• Cleveland doesn't have a win ATS (0-1) as a 10.5-point underdog or greater this year.
• The Browns have seen seven of their 14 games go over the point total.

Check out even more in-depth Bills vs. Browns analysis on FanDuel Research.

Bills vs Browns Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BUF: (-649) | CLE: (+480)
• Spread: BUF: -10.5 (100) | CLE: +10.5 (-122)
• Total: 42.5 -- Over: (-108) | Under: (-112)

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