Iowa State vs Oklahoma Prediction, Odds, Spread, Date & Start Time for College Football Week 12 Game
By Larry Rupp

Iowa State vs Oklahoma Week 12 Game Info
Week 12 College Football Game
Iowa State Cyclones (6-4, 4-3 Big 12) vs. No. 8 Oklahoma Sooners (9-1, 6-1 Big 12)
Date: Saturday, November 20, 2021
Time: 12:00 p.m. EST
Venue: Memorial Stadium – Norman, OK
Coverage: FOX
Iowa State vs Oklahoma Spread & Odds
All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: ISU: (+154) | OU: (-192)
Spread: ISU: +3.5 (-105) | OU: -3.5 (-115)
Total: 61.5 – Over: (-114) | Under: (-106)
Iowa State vs Oklahoma Prediction & Pick
All NCAAF predictions & expert picks are according to numberFire.
Prediction: Iowa State wins (51.3%)
Iowa State vs Oklahoma Head-to-Head Record & Betting Trends
- Oklahoma is 77-7-2 straight up in 86 all-time head-to-head matchups against Iowa State.
- Oklahoma defeated Iowa State, 27-21, during their most recent meeting on Dec. 19, 2020.
- Iowa State is 5-1 against the spread (ATS) in its last six games against Oklahoma.
- The total has hit the over in five of Iowa state's last seven games.
- Oklahoma is 10-0 straight up in its last 10 home games.
- The total has hit the over in eight of Oklahoma's last 10 games against Iowa State.
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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.