NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 12

The Tampa Bay Buccaneers versus the Los Angeles Rams is a game to catch on a Week 12 NFL slate that features a lot of exciting matchups.

If you're seeking additional betting information for Week 12 in the NFL, we have you covered with betting odds for each of the important games.

Texans vs. Bills

Star running back James Cook and the Buffalo Bills (7-3) meet the Houston Texans (5-5) on Thursday at 8:15 p.m. ET at NRG Stadium.

• Game Preview: Buffalo Bills at Houston Texans
• Projected Favorite: Bills (61.76% win probability)
• Spread: Buffalo (-5.5)
• Total: 44.5 -- Over: (-106) | Under: (-114)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Houston vs. Buffalo with FanDuel Sportsbook.

Lions vs. Giants

The Detroit Lions (6-4), who have the fourth-ranked scoring offense in the NFL (29.2 points per game), will look to exploit the New York Giants' (2-9) 29th-ranked scoring defense (27.3 points conceded per contest) when the Lions host the Giants on Sunday, Nov. 23 at Ford Field. The game starts at 1 p.m. ET.

• Game Preview: New York Giants at Detroit Lions
• Projected Favorite: Lions (82.28% win probability)
• Spread: Detroit (-13.5)
• Total: 50.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Detroit vs. New York with FanDuel Sportsbook.

Chiefs vs. Colts

The Indianapolis Colts (8-2), who lead the league by scoring 32.1 points per game, will be tested by the fourth-ranked scoring defense of the Kansas City Chiefs (5-5), who allow opponents to score 18.1 per game. The game begins at 1 p.m. ET on Sunday, Nov. 23 at GEHA Field at Arrowhead Stadium.

• Game Preview: Indianapolis Colts at Kansas City Chiefs
• Projected Favorite: Chiefs (63.54% win probability)
• Spread: Kansas City (-3.5)
• Total: 49.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Kansas City vs. Indianapolis with FanDuel Sportsbook.

Packers vs. Vikings

After a 27-20 win versus the Giants in their previous contest, the Green Bay Packers (6-3-1) will host the Minnesota Vikings (4-6), who are coming off a 19-17 loss to the Bears. The game is scheduled for 1 p.m. ET on Sunday, Nov. 23.

• Game Preview: Minnesota Vikings at Green Bay Packers
• Projected Favorite: Packers (84.75% win probability)
• Spread: Green Bay (-6.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Green Bay vs. Minnesota with FanDuel Sportsbook.

Bengals vs. Patriots

The Cincinnati Bengals (3-7) and their 31st-ranked pass defense might have a hard time slowing down the New England Patriots (9-2) and Drake Maye, one of the NFL's top passers, when the Bengals host the Patriots at Paycor Stadium on Nov. 23 at 1 p.m. ET.

• Game Preview: New England Patriots at Cincinnati Bengals
• Projected Favorite: Patriots (72.90% win probability)
• Spread: New England (-7.5)
• Total: 50.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. New England with FanDuel Sportsbook.

Ravens vs. Jets

When the Baltimore Ravens (5-5) and the New York Jets (2-8) meet on Sunday, Nov. 23 at 1 p.m. ET, the Ravens will be looking to follow up their recent victory over the Browns with another win, and the Jets will be attempting to bounce back from a loss to the Patriots.

• Game Preview: New York Jets at Baltimore Ravens
• Projected Favorite: Ravens (82.70% win probability)
• Spread: Baltimore (-13.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. New York with FanDuel Sportsbook.

Bears vs. Steelers

The Pittsburgh Steelers (6-4) will visit the Chicago Bears (7-3) on Sunday at 1 p.m. ET.

• Game Preview: Pittsburgh Steelers at Chicago Bears
• Projected Favorite: Bears (59.94% win probability)
• Spread: Chicago (-2.5)
• Total: 45.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Chicago vs. Pittsburgh with FanDuel Sportsbook.

Titans vs. Seahawks

Expect plenty of points from the Seattle Seahawks (7-3) when they visit the Tennessee Titans (1-9) at Nissan Stadium on Nov. 23 at 1 p.m. ET. The Seahawks are owners of the NFL's third-ranked scoring offense, while the Titans sport the 29th-ranked defense.

• Game Preview: Seattle Seahawks at Tennessee Titans
• Projected Favorite: Seahawks (77.18% win probability)
• Spread: Seattle (-12.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tennessee vs. Seattle with FanDuel Sportsbook.

Raiders vs. Browns

Points may be hard to come by on Sunday, Nov. 23 at 4:05 p.m. ET, when the Las Vegas Raiders (2-8), who own the 30th-ranked scoring offense (15.5 points per game), challenge the Cleveland Browns (2-8) and their 29th-ranked offense (16.2 points per game).

• Game Preview: Cleveland Browns at Las Vegas Raiders
• Projected Favorite: Raiders (56.79% win probability)
• Spread: Las Vegas (-3.5)
• Total: 36.5 -- Over: (-104) | Under: (-118)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Cleveland with FanDuel Sportsbook.

Cardinals vs. Jaguars

Trey McBride and the Arizona Cardinals (3-7) play the Jacksonville Jaguars (6-4) on Sunday at 4:05 p.m. ET at State Farm Stadium.

• Game Preview: Jacksonville Jaguars at Arizona Cardinals
• Projected Favorite: Jaguars (50.45% win probability)
• Spread: Jacksonville (-2.5)
• Total: 46.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Arizona vs. Jacksonville with FanDuel Sportsbook.

Cowboys vs. Eagles

Star running back Javonte Williams and the Dallas Cowboys (4-5-1) face the Philadelphia Eagles (8-2) on Sunday at 4:25 p.m. ET, at AT&T Stadium.

• Game Preview: Philadelphia Eagles at Dallas Cowboys
• Projected Favorite: Eagles (54.75% win probability)
• Spread: Philadelphia (-3)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Dallas vs. Philadelphia with FanDuel Sportsbook.

Saints vs. Falcons

One of the top running backs in football will be featured when Bijan Robinson and the Atlanta Falcons (3-7) visit the New Orleans Saints (2-8) on Sunday, November 23, 2025.

• Game Preview: Atlanta Falcons at New Orleans Saints
• Projected Favorite: Falcons (50.02% win probability)
• Spread: New Orleans (-1.5)
• Total: 40.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Atlanta with FanDuel Sportsbook.

Rams vs. Buccaneers

Kyren Williams and the Los Angeles Rams (8-2) will host Emeka Egbuka and the Tampa Bay Buccaneers (6-4) on Sunday at 8:20 p.m. ET, in a battle featuring a pair of the brightest stars in football.

• Game Preview: Tampa Bay Buccaneers at Los Angeles Rams
• Projected Favorite: Rams (73.67% win probability)
• Spread: Los Angeles (-7)
• Total: 49.5 -- Over: (-110) | Under: (-110)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Los Angeles vs. Tampa Bay with FanDuel Sportsbook.

49ers vs. Panthers

Christian McCaffrey will lead the San Francisco 49ers (7-4) into their matchup versus the Carolina Panthers (6-5) at Levi's Stadium on Monday at 8:15 p.m. ET.

• Game Preview: Carolina Panthers at San Francisco 49ers
• Projected Favorite: 49ers (69.17% win probability)
• Spread: San Francisco (-7.5)
• Total: 49.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: ESPN

Bet on San Francisco vs. Carolina with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!