Best College Football Games Week 5: Predictions, Odds, Picks, Best Bets

Top-25 teams will hit the field across 12 games on the Week 5 college football schedule. That includes the No. 6 Oregon Ducks taking on the No. 3 Penn State Nittany Lions at West Shore Home Field at Beaver Stadium.

With Week 5 in college football upon us, stay on top of the latest betting odds with our preview below.

For additional insights, check out the latest college football betting picks from FanDuel Research's staff of writers.

Virginia vs. Florida State

• Matchup: No. 8 Florida State Seminoles at Virginia Cavaliers
• Projected Favorite: Florida State (53.48% win probability)
• Spread: Florida State (-6.5)
• Total: 59.5
• Time: 7 p.m. ET
• Date: Sept. 26
• TV Channel: ESPN

Bet on Virginia vs. Florida State with FanDuel Sportsbook.

Wake Forest vs. Georgia Tech

• Matchup: No. 16 Georgia Tech Yellow Jackets at Wake Forest Demon Deacons
• Projected Favorite: Georgia Tech (71.31% win probability)
• Spread: Georgia Tech (-13.5)
• Total: 52.5
• Time: 12 p.m. ET
• Date: Sept. 27
• TV Channel: ESPN

Bet on Wake Forest vs. Georgia Tech with FanDuel Sportsbook.

Vanderbilt vs. Utah State

• Matchup: Utah State Aggies at No. 18 Vanderbilt Commodores
• Projected Favorite: Vanderbilt (88.63% win probability)
• Spread: Vanderbilt (-23.5)
• Total: 58.5
• Time: 12:45 p.m. ET
• Date: Sept. 27
• TV Channel: SEC Network

Bet on Vanderbilt vs. Utah State with FanDuel Sportsbook.

Ole Miss vs. LSU

• Matchup: No. 4 LSU Tigers at No. 13 Ole Miss Rebels
• Projected Favorite: Ole Miss (70.53% win probability)
• Spread: Ole Miss (-2.5)
• Total: 57.5
• Time: 3:30 p.m. ET
• Date: Sept. 27
• TV Channel: ABC

Bet on Ole Miss vs. LSU with FanDuel Sportsbook.

Iowa vs. Indiana

• Matchup: No. 11 Indiana Hoosiers at Iowa Hawkeyes
• Projected Favorite: Indiana (77.10% win probability)
• Spread: Indiana (-9.5)
• Total: 47.5
• Time: 3:30 p.m. ET
• Date: Sept. 27
• TV Channel: Peacock

Bet on Iowa vs. Indiana with FanDuel Sportsbook.

Texas A&M vs. Auburn

• Matchup: Auburn Tigers at No. 9 Texas A&M Aggies
• Projected Favorite: Texas A&M (60.58% win probability)
• Spread: Texas A&M (-6.5)
• Total: 51.5
• Time: 3:30 p.m. ET
• Date: Sept. 27
• TV Channel: ESPN

Bet on Texas A&M vs. Auburn with FanDuel Sportsbook.

Washington vs. Ohio State

• Matchup: No. 1 Ohio State Buckeyes at Washington Huskies
• Projected Favorite: Ohio State (61.20% win probability)
• Spread: Ohio State (-8.5)
• Total: 53.5
• Time: 3:30 p.m. ET
• Date: Sept. 27
• TV Channel: CBS

Bet on Washington vs. Ohio State with FanDuel Sportsbook.

Mississippi State vs. Tennessee

• Matchup: No. 15 Tennessee Volunteers at Mississippi State Bulldogs
• Projected Favorite: Tennessee (73.82% win probability)
• Spread: Tennessee (-7.5)
• Total: 63.5
• Time: 4:15 p.m. ET
• Date: Sept. 27
• TV Channel: SEC Network

Bet on Mississippi State vs. Tennessee with FanDuel Sportsbook.

Iowa State vs. Arizona

• Matchup: Arizona Wildcats at No. 14 Iowa State Cyclones
• Projected Favorite: Iowa State (77.26% win probability)
• Spread: Iowa State (-4.5)
• Total: 48.5
• Time: 7 p.m. ET
• Date: Sept. 27
• TV Channel: ESPN

Bet on Iowa State vs. Arizona with FanDuel Sportsbook.

Penn State vs. Oregon

• Matchup: No. 6 Oregon Ducks at No. 3 Penn State Nittany Lions
• Projected Favorite: Penn State (69.48% win probability)
• Spread: Penn State (-3.5)
• Total: 53.5
• Time: 7:30 p.m. ET
• Date: Sept. 27
• TV Channel: NBC

Bet on Penn State vs. Oregon with FanDuel Sportsbook.

Missouri vs. UMass

• Matchup: UMass Minutemen at No. 20 Missouri Tigers
• Projected Favorite: Missouri (96.21% win probability)
• Spread: Missouri (-44.5)
• Total: 57.5
• Time: 7:30 p.m. ET
• Date: Sept. 27
• TV Channel: ESPNU

Bet on Missouri vs. UMass with FanDuel Sportsbook.

Georgia vs. Alabama

• Matchup: No. 17 Alabama Crimson Tide at No. 5 Georgia Bulldogs
• Projected Favorite: Georgia (52.97% win probability)
• Spread: Georgia (-2.5)
• Total: 53.5
• Time: 7:30 p.m. ET
• Date: Sept. 27
• TV Channel: ABC

Bet on Georgia vs. Alabama with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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