Florida State vs Virginia Prediction, Odds, Picks, Best Bets for Week 5 2025

The college football slate on Friday includes the Florida State Seminoles facing the Virginia Cavaliers.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Florida State vs Virginia Odds & Spread

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Florida State: (-250) | Virginia: (+202)
• Spread: Florida State: -6.5 (-120) | Virginia: +6.5 (-102)
• Total: 59.5 -- Over: (-115) | Under: (-105)

Florida State vs Virginia Betting Trends

• Florida State has won twice against the spread this year.
• Florida State has covered every time (1-0) as a 6.5-point favorite or greater this year.
• Two of two Florida State games have hit the over this season.
• Virginia's record against the spread in 2025 is 3-1-0.
• All four Virginia games have gone over the point total this year.

Florida State vs Virginia Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Seminoles win (53.5%)

Florida State vs Virginia Point Spread

Florida State is favored by 6.5 points over Virginia. Florida State is -120 to cover the spread, with Virginia being -102.

Florida State vs Virginia Over/Under

An over/under of 59.5 has been set for Florida State-Virginia on Sept. 26, with the over being -115 and the under -105.

Florida State vs Virginia Moneyline

Virginia is the underdog, +202 on the moneyline, while Florida State is a -250 favorite.

Florida State vs. Virginia Points Insights

Florida State vs. Virginia Game Info

• Game day: Friday, September 26, 2025
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Charlottesville, Virginia
• Stadium: Scott Stadium

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Check out even more in-depth Florida State vs. Virginia analysis on FanDuel Research.