49ers vs Cardinals Point Spread, Over/Under, Moneyline and Betting Trends for NFL Week 5 Game

Week 5's slate of games includes a showdown between the San Francisco 49ers and Arizona Cardinals.

Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.

49ers vs Cardinals Point Spread

The Cardinals are 5.5-point home favorites against the 49ers. Arizona is -106 to cover the spread, while San Francisco is -114 to cover as a 5.5-point underdog.

49ers vs Cardinals Over/Under

The over/under for the 49ers vs Cardinals Week 5 NFL matchup is set at 48.5, with -108 odds on the over and -112 odds on the under.

49ers vs Cardinals Moneyline

The 49ers vs Cardinals moneyline has Arizona as a -235 favorite, while San Francisco is a +194 underdog on the road.

49ers vs Cardinals Betting Trends

- San Francisco is 3-9 straight up in its last 12 games against Arizona.
- The total has hit the under in five of San Francisco's last seven games against an NFC West opponent.
- Arizona is 5-1-1 against the spread (ATS) in its last seven games against San Francisco.
- The total has hit the over in six of Arizona's last seven home games.

49ers vs Cardinals Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (+194) | ARI: (-235)
Spread: SF: +5.5 (-114) | ARI: -5.5 (-106)
Total: 48.5 — Over: (-108) | Under: (-112)
Public (Spread) Betting Percentages via oddsFire: SF: (N/A) | ARI: (N/A)
Odds to Win Super Bowl LVI: SF: (+2100) | ARI: (+1500)

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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.