49ers vs Cardinals Spread, Odds, Line, Prediction and Betting Insights for Week 16 Saturday Night Football

By michael obermuller
San Francisco 49ers vs Arizona Cardinals spread, odds, line, over/under, prediction and betting insights for Week 16 NFL game.
San Francisco 49ers vs Arizona Cardinals spread, odds, line, over/under, prediction and betting insights for Week 16 NFL game. / Ezra Shaw/Getty Images
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49ers vs Cardinals Week 16 Game Info

NFL Week 16 Saturday Night Football Game
San Francisco 49ers (5-9, 4-3 Away) vs. Arizona Cardinals (8-6, 4-3 Home)
Date: Saturday, Dec. 26, 2020
Time: 4:30 p.m. EST
Venue: State Farm Stadium — Glendale, AZ
Coverage: Amazon Prime Video

49ers vs Cardinals Spread & Odds

All betting lines, odds, and prop bets are available on FanDuel Sportsbook.
Moneyline: SF: (+176) | ARI: (-210)
Spread: SF: +4.5 (-114) | ARI: -4.5 (-106)
Total: 48.5 – Over: (-115) | Under: (-105)
Public (Spread) Betting Percentages via oddsFire: SF: (12%) | ARI: (88%)
Odds to Win Super Bowl LV: SF: (N/A) | ARI: (+5500)

49ers vs Cardinals Expert Prediction & Pick

All 49ers-Cardinals expert predictions and picks are according to Sporting News.
Winner: Cardinals
Spread Pick: 49ers

49ers vs Cardinals Betting Trends

- San Francisco is 1-6 against the spread (ATS) in its last seven games.
- San Francisco is 1-6 straight up in its last seven games.
- Arizona is 2-5 ATS in its last seven games.
- The total has hit the over in each of Arizona's last five home games.

49ers vs Cardinals Stats

- San Francisco is averaging 23.8 per game (PPG) this season (No. 20 in the NFL).
- San Francisco is surrendering 25.1 PPG this season (No. 17 in the NFL).
- Arizona is averaging 27.9 PPG this season (No. 10 in the NFL).
- Arizona is surrendering 23.6 PPG this season (No. 13 in the NFL).


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Michael Obermuller is not a FanDuel employee. In addition to providing DFS gameplay advice, Michael Obermuller also participates in DFS contests on FanDuel using his personal account, username king_mizzard. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

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