Top 25 College Basketball Picks & Predictions Today - November 21

No. 15 Texas Tech and No. 1 Purdue match up at 9:30 p.m. ET, which is one of nine games on Friday that include teams ranked in the Top 25 AP Poll. See all of the matchups below, along with our picks and predictions.

Check out our betting preview for college basketball's action today.

BYU vs. Wisconsin

• Matchup: No. 23 Wisconsin Badgers vs. No. 9 BYU Cougars
• Projected Winner: Wisconsin (55.85% win probability)
• Spread: BYU (-3.5)
• Time: 4 p.m. ET
• Date: November 21
• TV Channel: Peacock

Bet on BYU vs. Wisconsin with FanDuel Sportsbook.

Michigan State vs. Detroit Mercy

• Matchup: Detroit Mercy Titans at No. 17 Michigan State Spartans
• Projected Winner: Michigan State (97.99% win probability)
• Spread: Michigan State (-31.5)
• Time: 6:30 p.m. ET
• Date: November 21
• TV Channel: BTN

Bet on Michigan State vs. Detroit Mercy with FanDuel Sportsbook.

Cincinnati vs. Louisville

• Matchup: No. 6 Louisville Cardinals vs. Cincinnati Bearcats
• Projected Winner: Louisville (66.66% win probability)
• Spread: Louisville (-8.5)
• Time: 6:30 p.m. ET
• Date: November 21
• TV Channel: ESPN2

Bet on Cincinnati vs. Louisville with FanDuel Sportsbook.

Kentucky vs. Loyola (MD)

• Matchup: Loyola (MD) Greyhounds at No. 12 Kentucky Wildcats
• Projected Winner: Kentucky (97.94% win probability)
• Spread: Kentucky (-35.5)
• Time: 7 p.m. ET
• Date: November 22
• TV Channel: SEC Network+

Bet on Kentucky vs. Loyola (MD) with FanDuel Sportsbook.

Duke vs. Niagara

• Matchup: Niagara Purple Eagles at No. 5 Duke Blue Devils
• Projected Winner: Duke (98.68% win probability)
• Spread: Duke (-39.5)
• Time: 7 p.m. ET
• Date: November 22
• TV Channel: ACC Network

Bet on Duke vs. Niagara with FanDuel Sportsbook.

Florida vs. Merrimack

• Matchup: Merrimack Warriors at No. 10 Florida Gators
• Projected Winner: Florida (95.93% win probability)
• Spread: Florida (-37.5)
• Time: 7 p.m. ET
• Date: November 22
• TV Channel: SEC Network+

Bet on Florida vs. Merrimack with FanDuel Sportsbook.

Arkansas vs. Jackson State

• Matchup: Jackson State Tigers at No. 21 Arkansas Razorbacks
• Projected Winner: Arkansas (98.18% win probability)
• Spread: Arkansas (-29.5)
• Time: 8 p.m. ET
• Date: November 22
• TV Channel: SEC Network+

Bet on Arkansas vs. Jackson State with FanDuel Sportsbook.

Texas Tech vs. Purdue

• Matchup: No. 1 Purdue Boilermakers vs. No. 15 Texas Tech Red Raiders
• Projected Winner: Purdue (50.02% win probability)
• Spread: Purdue (-2.5)
• Time: 9:30 p.m. ET
• Date: November 22
• TV Channel: CBS Sports Network

Bet on Texas Tech vs. Purdue with FanDuel Sportsbook.

UCLA vs. Presbyterian

• Matchup: Presbyterian Blue Hose at No. 19 UCLA Bruins
• Projected Winner: UCLA (94.25% win probability)
• Spread: UCLA (-26.5)
• Time: 10:30 p.m. ET
• Date: November 22
• TV Channel: BTN

Bet on UCLA vs. Presbyterian with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

For more college basketball betting insights, check out FanDuel Research's college basketball home page.

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