Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 9:12 p.m.

In MLB action on Monday, the San Diego Padres take on the Cincinnati Reds.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Reds Game Info

• San Diego Padres (78-65) vs. Cincinnati Reds (72-71)
• Date: Monday, September 8, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSOH

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-138) | CIN: (+118)
• Spread: SD: -1.5 (+152) | CIN: +1.5 (-184)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 3-5, 5.75 ERA vs Nick Lodolo (Reds) - 8-7, 3.22 ERA

This contest's pitching matchup is set, as the Padres will send Yu Darvish (3-5) to the mound, while Nick Lodolo (8-7) will get the nod for the Reds. Darvish and his team have a record of 7-3-0 against the spread when he starts. When Darvish starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Reds have gone 12-10-0 against the spread when Lodolo starts. The Reds are 5-7 in Lodolo's 12 starts this season that they were the underdog on the moneyline.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.3%)

Padres vs Reds Moneyline

• Looking at the moneyline for Reds-Padres, Cincinnati is the underdog at +118, and San Diego is -138 playing at home.

Padres vs Reds Spread

• The Padres are favored by 1.5 runs at home versus the Reds. The Padres are +152 to cover the spread, while the Reds are -184.

Padres vs Reds Over/Under

• The over/under for the Padres versus Reds contest on Sept. 8 has been set at 7.5, with -100 odds on the over and -122 odds on the under.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have been chosen as favorites in 75 games this year and have walked away with the win 45 times (60%) in those games.
• This season San Diego has been victorious 30 times in 50 chances when named as a favorite of at least -138 on the moneyline.
• Contests with the Padres have gone over the total set by oddsmakers in 62 of 141 chances this season.
• In 141 games with a line this season, the Padres have a mark of 77-64-0 against the spread.
• The Reds have won 47.4% of the games this season they were the moneyline underdog (36-40).
• Cincinnati has a record of 15-22 when playing as a moneyline underdog with odds of +118 or longer (40.5%).
• The Reds have combined with opponents to hit the over on the total 54 times this season for a 54-74-8 record against the over/under.
• The Reds have collected a 70-66-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is hitting .262 with 27 doubles, two triples, 20 home runs and 83 walks. He has an on-base percentage of .367 while slugging .433.
• He is 70th in batting average, 15th in on-base percentage, and 78th in slugging among all qualifying hitters in baseball.
• Tatis hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .227 with two home runs, two walks and four RBIs.
• Manny Machado leads San Diego in total hits (155) this season while batting .280 with 56 extra-base hits. He's slugging .465 with an on-base percentage of .342.
• His batting average ranks 24th among qualified players, his on-base percentage 50th, and his slugging percentage 46th.
• Luis Arraez has hit seven homers with a team-high .389 SLG this season.
• Ramon Laureano has 23 home runs, 71 RBI and a batting average of .300 this season.
• Laureano has safely hit in eight games in a row. During his last 10 outings he is hitting .300 with two doubles, two home runs, two walks and five RBIs.

Reds Player Leaders

• Elly De La Cruz has racked up a slugging percentage of .445 and has 150 hits, both team-best numbers for the Reds. He's batting .267 and with an on-base percentage of .336.
• He is 48th in batting average, 63rd in on-base percentage and 68th in slugging percentage among all qualified hitters in the big leagues.
• TJ Friedl's .366 OBP paces his team. He has a batting average of .265 while slugging .376.
• Including all qualifying hitters, his batting average puts him 57th, his on-base percentage is 17th, and he is 132nd in slugging.
• Spencer Steer has 20 doubles, two triples, 17 home runs and 45 walks while batting .239.
• Austin Hays is hitting .263 with 15 doubles, five triples, 14 home runs and 27 walks.

Padres vs Reds Head to Head

• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2024: 5-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/2/2023: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 11, Favorite Moneyline: -132, Underdog Moneyline: +112)

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