Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 11:12 a.m.

The MLB slate on Monday includes the San Diego Padres taking on the Cincinnati Reds.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Reds Game Info

• San Diego Padres (78-65) vs. Cincinnati Reds (72-71)
• Date: Monday, September 8, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSOH

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-144) | CIN: (+122)
• Spread: SD: -1.5 (+152) | CIN: +1.5 (-184)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 3-5, 5.75 ERA vs Nick Lodolo (Reds) - 8-7, 3.22 ERA

The Padres will give the nod to Yu Darvish (3-5) against the Reds and Nick Lodolo (8-7). Darvish's team is 7-3-0 against the spread in his starts this season. Darvish's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 2-2. The Reds have a 12-10-0 record against the spread in Lodolo's starts. The Reds are 5-7 in Lodolo's 12 starts this season that they were the moneyline underdog.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.3%)

Padres vs Reds Moneyline

• San Diego is a -144 favorite on the moneyline, while Cincinnati is a +122 underdog on the road.

Padres vs Reds Spread

• The Reds are +1.5 on the spread (-184 to cover), and San Diego is +152 to cover the runline.

Padres vs Reds Over/Under

• A total of 7.5 runs has been set for the Padres-Reds game on Sept. 8, with the over available at -110 and the under at -110.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have won in 45, or 60%, of the 75 contests they have been named as odds-on favorites in this year.
• This year San Diego has won 27 of 45 games when listed as at least -144 on the moneyline.
• The Padres and their opponents have gone over in 62 of their 141 games with a total set by sportsbooks this season.
• The Padres are 77-64-0 against the spread in their 141 games that had a posted line this season.
• The Reds have been the moneyline underdog 76 total times this season. They've gone 36-40 in those games.
• In games it has played as a moneyline underdog with odds of +122 or longer, Cincinnati has a 14-18 record (winning 43.8% of its games).
• In the 136 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 54 times (54-74-8).
• The Reds have covered 51.5% of their games this season, going 70-66-0 ATS.

Padres Player Leaders

• Fernando Tatis Jr. is hitting .262 with 27 doubles, two triples, 20 home runs and 83 walks. He has an on-base percentage of .367 while slugging .433.
• Among all qualified hitters in baseball, he is 70th in batting average, 15th in on-base percentage, and 78th in slugging.
• Tatis has recorded at least one hit in four straight games. In his last five games he is batting .227 with two home runs, two walks and four RBIs.
• Manny Machado leads San Diego with 155 hits. He is batting .280 this season and has 56 extra-base hits. He's also slugging .465 with an on-base percentage of .342.
• His batting average ranks 24th among qualified players, his on-base percentage 50th, and his slugging percentage 46th.
• Luis Arraez has hit seven homers with a team-high .389 SLG this season.
• Ramon Laureano is batting .300 with a .360 OBP and 71 RBI for San Diego this season.
• Laureano has safely hit in eight straight games. During his last 10 outings he is batting .300 with two doubles, two home runs, two walks and five RBIs.

Reds Player Leaders

• Elly De La Cruz has put up a team-high slugging percentage (.445) while leading the Reds in hits (150). He's batting .267 and with an on-base percentage of .336.
• Including all qualifying players, he is 48th in batting average, while his on-base percentage is 63rd and he is 68th in slugging.
• TJ Friedl paces his team with a .366 on-base percentage. He has a batting average of .265 while slugging .376.
• Including all qualified players, he is 57th in batting average, 17th in on-base percentage and 132nd in slugging percentage.
• Spencer Steer is hitting .239 with 20 doubles, two triples, 17 home runs and 45 walks.
• Austin Hays has 15 doubles, five triples, 14 home runs and 27 walks while hitting .263.

Padres vs Reds Head to Head

• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/23/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/22/2024: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/21/2024: 2-0 CIN (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/1/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/30/2024: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2024: 5-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/2/2023: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 11, Favorite Moneyline: -132, Underdog Moneyline: +112)

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