Mariners vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 11:12 a.m.

The MLB's Monday schedule includes the Seattle Mariners facing the St. Louis Cardinals.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Cardinals Game Info

• Seattle Mariners (75-68) vs. St. Louis Cardinals (72-72)
• Date: Monday, September 8, 2025
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ROOT Sports NW and FDSMW

Mariners vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-225) | STL: (+188)
• Spread: SEA: -1.5 (-100) | STL: +1.5 (-120)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Mariners vs Cardinals Probable Starting Pitchers

Probable Pitchers: Bryan Woo (Mariners) - 12-7, 3.02 ERA vs Miles Mikolas (Cardinals) - 7-10, 4.89 ERA

The Mariners will give the ball to Bryan Woo (12-7, 3.02 ERA), who is eyeing win No. 13 on the season, and the Cardinals will counter with Miles Mikolas (7-10, 4.89 ERA). When Woo starts, his team is 10-17-0 against the spread this season. Woo's team has been victorious in 52.4% of the games he's started as the moneyline favorite with a record of 11-10. The Cardinals have gone 12-15-0 ATS in Mikolas' 27 starts that had a set spread. The Cardinals have an 8-11 record in Mikolas' 19 starts this season when they were the underdog on the moneyline.

Mariners vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (66.5%)

Mariners vs Cardinals Moneyline

• The moneyline numbers for Mariners vs. Cardinals reveal Seattle as the favorite (-225) and St. Louis as the underdog (+188) on the road.

Mariners vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Mariners. The Cardinals are -120 to cover, and the Mariners are -100.

Mariners vs Cardinals Over/Under

• An over/under of 7.5 has been set for Mariners-Cardinals on Sept. 8, with the over being -110 and the under -110.

Bet on Seattle Mariners vs. St. Louis Cardinals on FanDuel today!

Mariners vs Cardinals Betting Trends

• The Mariners have won in 53, or 55.2%, of the 96 contests they have been named as odds-on favorites in this year.
• This season Seattle has come away with a win three times in four chances when named as a favorite of at least -225 on the moneyline.
• The Mariners and their opponents have gone over in 74 of their 138 games with a total set by sportsbooks this season.
• The Mariners have an against the spread mark of 58-80-0 in 138 games with a line this season.
• The Cardinals have been the underdog on the moneyline 74 total times this season. They've finished 37-37 in those games.
• St. Louis has never played a game this season with moneyline odds of +188 or longer.
• The Cardinals have had an over/under set by bookmakers 138 times, and have combined with opponents to go over the total in 71 of those games (71-62-5).
• The Cardinals have collected a 70-68-0 record ATS this season (covering 50.7% of the time).

Mariners Player Leaders

• Cal Raleigh has 128 hits, which is tops among Seattle hitters this season, while batting .243 with 72 extra-base hits. He has an on-base percentage of .351 and a slugging percentage of .581.
• Among qualifying hitters in baseball, his batting average ranks 109th, his on-base percentage ranks 38th, and he is third in slugging.
• Raleigh hopes to build on a six-game hitting streak in this matchup. During his last 10 outings he is batting .211 with three home runs, six walks and six RBIs.
• Julio Rodriguez has hit 30 homers this season while driving in 89 runs. He's batting .267 this season and slugging .479 with an on-base percentage of .318.
• He ranks 48th in batting average, 99th in on-base percentage and 32nd in slugging in the majors.
• Rodriguez brings a two-game streak with at least one hit into this one. During his last five outings he is hitting .333 with two doubles, four home runs and 11 RBIs.
• Josh Naylor has collected 136 base hits, an OBP of .345 and a slugging percentage of .448 this season.
• Naylor enters this game with two games in a row with at least one hit. During his last five outings he is batting .250 with two home runs, a walk and four RBIs.
• Eugenio Suarez is batting .238 with a .309 OBP and 109 RBI for Seattle this season.
• Suarez has hit safely in two straight games. In his last five games he is batting .238 with three home runs, two walks and four RBIs.

Cardinals Player Leaders

• Masyn Winn has put up a team-high .365 slugging percentage. He's batting .254 with an on-base percentage of .312.
• Including all qualifying hitters in the big leagues, he is 87th in batting average, 111th in on-base percentage and 139th in slugging percentage.
• Lars Nootbaar has 22 doubles, a triple, 13 home runs and 55 walks while hitting .241. He's slugging .381 with an on-base percentage of .328.
• He is currently 118th in batting average, 78th in on-base percentage and 128th in slugging percentage among all qualifying batters.
• Ivan Herrera is hitting .283 with 12 doubles, 14 home runs and 34 walks.
• Victor Scott II is hitting .226 with 14 doubles, a triple, five home runs and 38 walks.

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