Mariners vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 9:12 p.m.

The Seattle Mariners will take on the St. Louis Cardinals in MLB action on Monday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Mariners vs Cardinals Game Info

• Seattle Mariners (75-68) vs. St. Louis Cardinals (72-72)
• Date: Monday, September 8, 2025
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ROOT Sports NW and FDSMW

Mariners vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-250) | STL: (+205)
• Spread: SEA: -1.5 (-120) | STL: +1.5 (-100)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Mariners vs Cardinals Probable Starting Pitchers

Probable Pitchers: Bryan Woo (Mariners) - 12-7, 3.02 ERA vs Miles Mikolas (Cardinals) - 7-10, 4.89 ERA

The probable pitchers are Bryan Woo (12-7) for the Mariners and Miles Mikolas (7-10) for the Cardinals. When Woo starts, his team is 10-17-0 against the spread this season. Woo's team is 11-10 this season when he starts and they are the moneyline favorite. When Mikolas starts, the Cardinals have gone 12-15-0 against the spread. The Cardinals have been the moneyline underdog in 19 of Mikolas' starts this season, and they went 8-11 in those games.

Mariners vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (66.5%)

Mariners vs Cardinals Moneyline

• Seattle is a -250 favorite on the moneyline, while St. Louis is a +205 underdog on the road.

Mariners vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Mariners. The Cardinals are -100 to cover the spread, and the Mariners are -120.

Mariners vs Cardinals Over/Under

• A combined run total of 7.5 has been set for Mariners-Cardinals on Sept. 8, with the over at -120 and the under at -102.

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Mariners vs Cardinals Betting Trends

• The Mariners have been victorious in 53, or 55.2%, of the 96 contests they have been chosen as favorites in this season.
• Seattle has a record of 3-1 when favored by -250 or more this year.
• The Mariners and their opponents have gone over in 74 of their 138 games with a total set by sportsbooks this season.
• In 138 games with a line this season, the Mariners have a mark of 58-80-0 against the spread.
• The Cardinals have put together a 37-37 record in games they were listed as the moneyline underdog (winning 50% of those games).
• St. Louis has yet to play a game with moneyline odds of +205 or longer.
• The Cardinals have had an over/under set by oddsmakers 138 times, and have combined with opponents to go over the total in 71 of those games (71-62-5).
• The Cardinals are 70-68-0 ATS this season.

Mariners Player Leaders

• Cal Raleigh has 128 hits, which is best among Seattle hitters this season, while batting .243 with 72 extra-base hits. He has an on-base percentage of .351 and a slugging percentage of .581.
• Among qualifying hitters in baseball, he is 109th in batting average, 38th in on-base percentage, and third in slugging.
• Raleigh hopes to build on a six-game hitting streak in this matchup. During his last 10 games he is batting .211 with three home runs, six walks and six RBIs.
• Julio Rodriguez has hit 30 homers this season while driving in 89 runs. He's batting .267 this season and slugging .479 with an on-base percentage of .318.
• He is 48th in batting average, 99th in on-base percentage and 32nd in slugging in MLB.
• Rodriguez heads into this game looking to extend his two-game hit streak. In his last five games he is batting .333 with two doubles, four home runs and 11 RBIs.
• Josh Naylor has 136 hits this season and has a slash line of .282/.345/.448.
• Naylor has picked up a hit in two games in a row. In his last five games he is batting .250 with two home runs, a walk and four RBIs.
• Eugenio Suarez has been key for Seattle with 122 hits, an OBP of .309 plus a slugging percentage of .550.
• Suarez brings a two-game hitting streak into this matchup. In his last five games he is hitting .238 with three home runs, two walks and four RBIs.

Cardinals Player Leaders

• Alec Burleson paces the Cardinals with 123 hits. He's batting .286 and slugging .451 with an on-base percentage of .337.
• Including all qualified players, he is 17th in batting average, while his on-base percentage ranks 60th and he is 56th in slugging.
• Masyn Winn's .365 slugging percentage paces his team. He has a batting average of .254 with an on-base percentage of .312.
• Including all qualifying players, he ranks 87th in batting average, 111th in on-base percentage and 139th in slugging percentage.
• Lars Nootbaar is batting .241 with 22 doubles, a triple, 13 home runs and 55 walks.
• Ivan Herrera is batting .283 with 12 doubles, 14 home runs and 34 walks.

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