Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 14

Odds updated as of 1:12 p.m.

The Cleveland Guardians are among the MLB teams playing on Sunday, up against the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this game.

Guardians vs White Sox Game Info

• Cleveland Guardians (77-71) vs. Chicago White Sox (57-92)
• Date: Sunday, September 14, 2025
• Time: 1:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-162) | CHW: (+136)
• Spread: CLE: -1.5 (+132) | CHW: +1.5 (-160)
• Total: 8 -- Over: (-100) | Under: (-122)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Slade Cecconi (Guardians) - 6-6, 4.45 ERA vs Yoendrys Gomez (White Sox) - 3-2, 5.05 ERA

This contest's pitching matchup is set, as the Guardians will send Slade Cecconi (6-6) to the mound, while Yoendrys Gomez (3-2) will answer the bell for the White Sox. Cecconi and his team have a record of 12-7-0 against the spread when he starts. Cecconi's team has a record of 5-3 this season when he starts and they are the favorite on the moneyline. The White Sox have a 5-1-0 record against the spread in Gomez's starts. The White Sox are 4-2 in Gomez's six starts this season that they were the moneyline underdog.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (55.6%)

Guardians vs White Sox Moneyline

• Chicago is the underdog, +136 on the moneyline, while Cleveland is a -162 favorite at home.

Guardians vs White Sox Spread

• The White Sox are at the Guardians, and are +1.5 on the runline. The White Sox are +132 to cover the spread, and the Guardians are -160.

Guardians vs White Sox Over/Under

• A combined run total of 8 has been set for Guardians-White Sox on Sept. 14, with the over at -100 and the under at -122.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been chosen as favorites in 61 games this year and have walked away with the win 39 times (63.9%) in those games.
• This season Cleveland has been victorious nine times in 10 chances when named as a favorite of at least -162 on the moneyline.
• The Guardians and their opponents have gone over in 63 of their 145 games with a total set by sportsbooks this season.
• The Guardians are 78-67-0 against the spread in their 145 games with a line set by sportsbooks this season.
• The White Sox are 53-88 in games they were the underdog on the moneyline (winning 37.6% of those games).
• Chicago has a record of 27-59 in games it has played as a moneyline underdog with odds of +136 or longer (31.4%).
• The White Sox have had an over/under set by oddsmakers 144 times, and have combined with opponents to go over the total in 67 of those games (67-69-8).
• The White Sox have collected an 82-62-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez has 152 hits and an OBP of .354, both of which rank first among Cleveland hitters this season. He has a .280 batting average and a slugging percentage of .500.
• He is 22nd in batting average, 32nd in on-base percentage, and 18th in slugging among qualifying hitters in the majors.
• Steven Kwan has hit 10 homers this season while driving in 48 runs. He's batting .275 this season and slugging .377 with an on-base percentage of .334.
• Among qualifiers, he is 31st in batting average, 63rd in on-base percentage and 127th in slugging percentage.
• Kyle Manzardo has 100 hits this season and has a slash line of .239/.322/.470.
• Angel Martinez is batting .226 with a .266 OBP and 42 RBI for Cleveland this season.

White Sox Player Leaders

• Miguel Vargas a has .311 on-base percentage to lead the White Sox. He's batting .229 while slugging .395.
• Including all the qualifying hitters in MLB, he is 136th in batting average, 111th in on-base percentage and 108th in slugging percentage.
• Andrew Benintendi is batting .243 with 16 doubles, two triples, 19 home runs and 37 walks. He's slugging .431 with an on-base percentage of .306.
• Lenyn Sosa has a team-best slugging percentage (.431) and leads the White Sox in hits (125).
• Chase Meidroth is hitting .269 with 15 doubles, four home runs and 43 walks.

Guardians vs White Sox Head to Head

• 9/13/2025: 3-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/12/2025: 4-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/10/2025: 6-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/9/2025: 3-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/8/2025: 9-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/13/2025: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/12/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2025: 5-4 CHW (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/10/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -245, Underdog Moneyline: +200)

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