Giants vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 11:12 a.m.

The San Francisco Giants will take on the Arizona Diamondbacks in MLB action on Monday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Giants vs Diamondbacks Game Info

• San Francisco Giants (72-71) vs. Arizona Diamondbacks (72-72)
• Date: Monday, September 8, 2025
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: Fox Sports 1, NBCS-BA, and ARID

Giants vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-190) | ARI: (+160)
• Spread: SF: -1.5 (+116) | ARI: +1.5 (-140)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Giants vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 13-9, 3.17 ERA vs Nabil Crismatt (Diamondbacks) - 2-0, 2.14 ERA

The Giants will give the nod to Logan Webb (13-9, 3.17 ERA), who is eyeing win No. 14 on the season, and the Diamondbacks will turn to Nabil Crismatt (2-0, 2.14 ERA). When Webb starts, his team is 13-16-0 against the spread this season. Webb's team has won 50% of his starts when they are favored on the moneyline (13-13). When Crismatt starts, the Diamondbacks have gone 2-1-0 against the spread. The Diamondbacks were the underdog on the moneyline for one Crismatt start this season -- they won.

Giants vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (57.2%)

Giants vs Diamondbacks Moneyline

• Arizona is a +160 underdog on the moneyline, while San Francisco is a -190 favorite at home.

Giants vs Diamondbacks Spread

• The Giants are favored by 1.5 runs at home against the Diamondbacks. The Giants are +116 to cover the spread, while the Diamondbacks are -140.

Giants vs Diamondbacks Over/Under

• The Giants-Diamondbacks game on Sept. 8 has been given an over/under of 7.5 runs. The over is set at -115 and the under at -105.

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Giants vs Diamondbacks Betting Trends

• The Giants have been favorites in 85 games this season and have come away with the win 45 times (52.9%) in those contests.
• This year San Francisco has won eight of 13 games when listed as at least -190 on the moneyline.
• The Giants and their opponents have gone over the total this season in 67 of their 142 opportunities.
• The Giants have posted a record of 66-76-0 against the spread this season.
• The Diamondbacks have been the underdog on the moneyline 57 total times this season. They've gone 28-29 in those games.
• When playing as a moneyline underdog with odds of +160 or longer, Arizona has a record of 2-2 (50%).
• In the 140 games bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 69 times (69-65-6).
• The Diamondbacks have a 69-71-0 record ATS this season.

Giants Player Leaders

• Rafael Devers has 141 hits and an OBP of .380, both of which are tops among San Francisco hitters this season. He has a .263 batting average and a slugging percentage of .492.
• He ranks 67th in batting average, ninth in on-base percentage, and 25th in slugging among qualified batters in the majors.
• Jung Hoo Lee is hitting .267 with 30 doubles, 11 triples, seven home runs and 44 walks. He's slugging .411 with an on-base percentage of .329.
• Among qualified hitters, his batting average places him 48th, his on-base percentage 76th, and his slugging percentage 89th.
• Willy Adames has 119 hits this season and has a slash line of .228/.317/.425.
• Heliot Ramos has an OPS of .740, fueled by an OBP of .339 and a team-best slugging percentage of .401 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has a .447 slugging percentage, which leads the Diamondbacks. He's batting .284 with an on-base percentage of .382.
• Including all the qualifying hitters in the big leagues, his batting average places him 19th, his on-base percentage ranks seventh, and he is 63rd in slugging.
• Corbin Carroll's 131 hits lead his team. He has a batting average of .259 while slugging .558 with an on-base percentage of .336.
• Including all qualified hitters, he is 79th in batting average, 63rd in on-base percentage and sixth in slugging percentage.
• Ketel Marte a has .386 on-base percentage to pace the Diamondbacks.
• Gabriel Moreno is batting .277 with 11 doubles, a triple, seven home runs and 17 walks.

Giants vs Diamondbacks Head to Head

• 7/3/2025: 7-2 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/2/2025: 6-5 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/1/2025: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/30/2025: 4-2 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/14/2025: 8-7 ARI (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2025: 10-6 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/12/2025: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 9/24/2024: 11-0 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/23/2024: 6-3 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)

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