Yankees vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 6:13 p.m.

MLB action on Thursday includes the New York Yankees taking on the Chicago White Sox.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs White Sox Game Info

• New York Yankees (90-68) vs. Chicago White Sox (58-100)
• Date: Thursday, September 25, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and CHSN

Yankees vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-310) | CHW: (+250)
• Spread: NYY: -1.5 (-144) | CHW: +1.5 (+120)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Yankees vs White Sox Probable Starting Pitchers

Probable Pitchers: Carlos Rodon (Yankees) - 17-9, 3.04 ERA vs Davis Martin (White Sox) - 7-10, 4.03 ERA

The probable starters are Carlos Rodon (17-9) for the Yankees and Davis Martin (7-10) for the White Sox. When Rodon starts, his team is 13-19-0 against the spread this season. Rodon's team has a record of 17-14 this season when he starts and they are the favorite on the moneyline. The White Sox have a 12-11-0 record against the spread in Martin's starts. The White Sox have a 9-14 record in Martin's 23 starts this season when they were the moneyline underdog.

Yankees vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (73.9%)

Yankees vs White Sox Moneyline

• New York is the favorite, -310 on the moneyline, while Chicago is a +250 underdog on the road.

Yankees vs White Sox Spread

• The Yankees are favored by 1.5 runs at home versus the White Sox. The Yankees are -144 to cover the spread, while the White Sox are +120.

Yankees vs White Sox Over/Under

• Yankees versus White Sox, on Sept. 25, has an over/under of 8.5, with the over being -122 and the under -100.

Bet on New York Yankees vs. Chicago White Sox on FanDuel today!

Yankees vs White Sox Betting Trends

• The Yankees have been chosen as favorites in 134 games this year and have walked away with the win 81 times (60.4%) in those games.
• This season New York has come away with a win two times in three chances when named as a favorite of at least -310 on the moneyline.
• The Yankees and their opponents have hit the over in 75 of their 156 games with a total set by oddsmakers this season.
• The Yankees are 73-83-0 against the spread in their 156 games that had a posted line this season.
• The White Sox have been the moneyline underdog 149 total times this season. They've gone 54-95 in those games.
• Chicago has not won a game when it entered play as a moneyline underdog with odds of +250 or longer in four chances.
• In the 153 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 70 times (70-75-8).
• The White Sox have collected an 87-66-0 record against the spread this season (covering 56.9% of the time).

Yankees Player Leaders

• Aaron Judge leads New York in OBP (.455), slugging percentage (.681) and total hits (173) this season. He has a .328 batting average.
• Among qualified hitters in baseball, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Cody Bellinger has 25 doubles, five triples, 29 home runs and 53 walks. He's batting .269 and slugging .481 with an on-base percentage of .329.
• His batting average is 41st among qualified players, his on-base percentage 72nd, and his slugging percentage 29th.
• Trent Grisham has collected 114 base hits, an OBP of .349 and a slugging percentage of .472 this season.
• Jazz Chisholm is batting .247 with a .337 OBP and 80 RBI for New York this season.
• Chisholm heads into this game on a six-game hitting streak. During his last 10 outings he is batting .256 with two doubles, two home runs, two walks and five RBIs.

White Sox Player Leaders

• Miguel Vargas has accumulated an on-base percentage of .312, a team-best for the White Sox. He's batting .231 and slugging .397.
• Including all the qualified players in MLB, he is 132nd in batting average, 106th in on-base percentage and 107th in slugging percentage.
• Vargas heads into this matchup on a five-game hitting streak. In his last five games he is hitting .333 with a double, a home run, three walks and four RBIs.
• Lenyn Sosa leads his team with 131 hits and has a club-high .423 slugging percentage. He has a batting average of .259 with an on-base percentage of .288.
• Including all qualifying hitters, he is 70th in batting average, 135th in on-base percentage and 76th in slugging percentage.
• Chase Meidroth is hitting .260 with 15 doubles, five home runs and 45 walks.
• Edgar Quero has 17 doubles, five home runs and 31 walks while batting .272.

Yankees vs White Sox Head to Head

• 9/24/2025: 8-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -390, Underdog Moneyline: +310)
• 9/23/2025: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/31/2025: 3-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 8/30/2025: 5-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/29/2025: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/28/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/14/2024: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/13/2024: 4-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 8/12/2024: 12-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -355, Underdog Moneyline: +285)
• 5/19/2024: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)

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