Dodgers vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 12:12 a.m.

The Thursday schedule in MLB includes a matchup between the Los Angeles Dodgers and the Arizona Diamondbacks.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Diamondbacks Game Info

• Los Angeles Dodgers (88-69) vs. Arizona Diamondbacks (80-77)
• Date: Thursday, September 25, 2025
• Time: 3:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: MLB Network, ARID, and SportsNet LA

Dodgers vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-146) | ARI: (+124)
• Spread: LAD: -1.5 (+112) | ARI: +1.5 (-134)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Dodgers vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Yoshinobu Yamamoto (Dodgers) - 11-8, 2.58 ERA vs Zac Gallen (Diamondbacks) - 13-14, 4.70 ERA

The Dodgers will give the nod to Yoshinobu Yamamoto (11-8, 2.58 ERA), who is eyeing win No. 12 on the season, and the Diamondbacks will turn to Zac Gallen (13-14, 4.70 ERA). When Yamamoto starts, his team is 12-17-0 against the spread this season. Yamamoto's team has won 53.6% of his starts when they are favored on the moneyline (15-13). The Diamondbacks have a 15-17-0 ATS record in Gallen's 32 starts with a set spread. The Diamondbacks have a 7-6 record in Gallen's 13 starts this season when they were the underdog on the moneyline.

Dodgers vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (58.9%)

Dodgers vs Diamondbacks Moneyline

• Los Angeles is a -146 favorite on the moneyline, while Arizona is a +124 underdog at home.

Dodgers vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the spread (-134 to cover), and Los Angeles is +112 to cover the runline.

Dodgers vs Diamondbacks Over/Under

• The over/under for Dodgers-Diamondbacks on Sept. 25 is 8.5. The over is -110, and the under is -110.

Bet on Los Angeles Dodgers vs. Arizona Diamondbacks on FanDuel today!

Dodgers vs Diamondbacks Betting Trends

• The Dodgers have been favorites in 138 games this season and have come away with the win 78 times (56.5%) in those contests.
• This year Los Angeles has won 58 of 103 games when listed as at least -146 on the moneyline.
• The Dodgers and their opponents have gone over in 74 of their 155 games with a total set by sportsbooks this season.
• The Dodgers have an against the spread mark of 66-89-0 in 155 games with a line this season.
• The Diamondbacks have won 33 of the 65 games they were the underdog on the moneyline this season (50.8%).
• Arizona has gone 14-8 when playing as a moneyline underdog with odds of +124 or longer (63.6%).
• In the 153 games bookmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 76 times (76-69-8).
• The Diamondbacks have a 77-76-0 record ATS this season (covering 50.3% of the time).

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles with 167 hits and an OBP of .394, plus a team-best slugging percentage of .617. He's batting .282.
• Among qualifying hitters in baseball, he is 22nd in batting average, third in on-base percentage, and second in slugging.
• Mookie Betts has 23 doubles, two triples, 20 home runs and 60 walks. He's batting .258 and slugging .410 with an on-base percentage of .327.
• Among qualifying batters, he ranks 74th in batting average, 76th in on-base percentage and 87th in slugging percentage.
• Freddie Freeman has collected 159 base hits, an OBP of .363 and a slugging percentage of .487 this season.
• Freeman brings a three-game hitting streak into this matchup. During his last five outings he is hitting .211 with a walk and two RBIs.
• Andy Pages has 25 home runs, 82 RBI and a batting average of .277 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has accumulated an on-base percentage of .391 and a slugging percentage of .461. Both lead the Diamondbacks. He's batting .291.
• Including all qualified hitters, he is 14th in batting average, while his on-base percentage ranks fourth and he is 46th in slugging.
• Perdomo hopes to build on a 12-game hitting streak in this matchup. In his last 10 outings he is hitting .395 with four doubles, a triple, a home run, six walks and five RBIs.
• Corbin Carroll paces his team with 144 hits. He has a batting average of .260 while slugging .545 with an on-base percentage of .341.
• He is 63rd in batting average, 52nd in on-base percentage and fifth in slugging percentage in MLB.
• Ketel Marte is batting .280 with 26 doubles, 26 home runs and 63 walks.
• Gabriel Moreno is batting .287 with 12 doubles, a triple, nine home runs and 26 walks.

Dodgers vs Diamondbacks Head to Head

• 9/23/2025: 5-4 ARI (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/31/2025: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 8/30/2025: 6-1 ARI (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 8/29/2025: 3-0 ARI (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 5/21/2025: 3-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/20/2025: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 5/19/2025: 9-5 ARI (Favorite: Dodgers, Spread: -1.5, Total: 10.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/11/2025: 8-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/10/2025: 3-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 14-11 LAD (Favorite: Diamondbacks, Spread: -1.5, Total: 10.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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