Yankees vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 2:12 a.m.

In MLB action on Wednesday, the New York Yankees play the Chicago White Sox.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Yankees vs White Sox Game Info

• New York Yankees (89-68) vs. Chicago White Sox (58-99)
• Date: Wednesday, September 24, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and CHSN

Yankees vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-375) | CHW: (+300)
• Spread: NYY: -1.5 (-160) | CHW: +1.5 (+132)
• Total: 8 -- Over: (-114) | Under: (-106)

Yankees vs White Sox Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 18-5, 2.92 ERA vs Fraser Ellard (White Sox) - 0-2, 4.50 ERA

The Yankees will give the nod to Max Fried (18-5, 2.92 ERA), who is eyeing win No. 19 on the season, and the White Sox will counter with Fraser Ellard (0-2, 4.50 ERA). Fried and his team are 18-13-0 ATS this season when he starts. When Fried starts a game and his team is the favorite on the moneyline, they have a record of 21-10. Ellard has started two games with set spreads, and the White Sox covered in both opportunities. The White Sox were the underdog on the moneyline for two Ellard starts this season -- they won both.

Yankees vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (75.3%)

Yankees vs White Sox Moneyline

• Chicago is the underdog, +300 on the moneyline, while New York is a -375 favorite at home.

Yankees vs White Sox Spread

• The White Sox are +1.5 on the run line against the Yankees. The White Sox are +132 to cover, and the Yankees are -160.

Yankees vs White Sox Over/Under

• A total of 8 runs has been set for the Yankees-White Sox game on Sept. 24, with the over available at -114 and the under at -106.

Bet on New York Yankees vs. Chicago White Sox on FanDuel today!

Yankees vs White Sox Betting Trends

• The Yankees have won in 80, or 60.2%, of the 133 contests they have been named as odds-on favorites in this year.
• These are the best odds of a victory sportsbooks have given New York this season, with a -375 moneyline set for this game.
• Contests with the Yankees have gone over the total set by sportsbooks in 74 of 155 chances this season.
• In 155 games with a line this season, the Yankees have a mark of 72-83-0 against the spread.
• The White Sox have been the moneyline underdog 148 total times this season. They've finished 54-94 in those games.
• Chicago has not yet played a game with moneyline odds of +300 or longer.
• The White Sox have combined with opponents to go over the total 69 times this season for a 69-75-8 record against the over/under.
• The White Sox have collected an 87-65-0 record against the spread this season.

Yankees Player Leaders

• Aaron Judge leads New York in OBP (.452), slugging percentage (.669) and total hits (170) this season. He has a .325 batting average.
• Among all qualified hitters in MLB, he ranks first in batting average, first in on-base percentage, and first in slugging.
• Cody Bellinger has 25 doubles, five triples, 29 home runs and 52 walks. He's batting .269 and slugging .483 with an on-base percentage of .328.
• Among qualified batters, his batting average places him 39th, his on-base percentage 70th, and his slugging percentage 28th.
• Trent Grisham is batting .236 with a .467 slugging percentage and 72 RBI this year.
• Jazz Chisholm is batting .247 with a .337 OBP and 79 RBI for New York this season.
• Chisholm has safely hit in five straight games. During his last five outings he is batting .412 with a double, two home runs, two walks and four RBIs.

White Sox Player Leaders

• Miguel Vargas a has .311 on-base percentage to pace the White Sox. He's batting .230 while slugging .397.
• He ranks 132nd in batting average, 105th in on-base percentage and 105th in slugging percentage among all qualified hitters in the big leagues.
• Vargas hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .263 with a double, a home run, two walks and four RBIs.
• Lenyn Sosa paces his team with 130 hits and has a club-high .423 slugging percentage. He has a batting average of .258 with an on-base percentage of .288.
• His batting average ranks 70th among all qualified players, his on-base percentage ranks 135th, and he is 76th in slugging.
• Chase Meidroth is batting .262 with 15 doubles, five home runs and 45 walks.
• Mike Tauchman is batting .263 with 17 doubles, a triple, nine home runs and 45 walks.

Yankees vs White Sox Head to Head

• 9/23/2025: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/31/2025: 3-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 8/30/2025: 5-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/29/2025: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/28/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/14/2024: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/13/2024: 4-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 8/12/2024: 12-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -355, Underdog Moneyline: +285)
• 5/19/2024: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/18/2024: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -295, Underdog Moneyline: +240)

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