Yankees vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 7:21 p.m.

The MLB's Wednesday slate includes the New York Yankees facing the Chicago White Sox.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs White Sox Game Info

• New York Yankees (89-68) vs. Chicago White Sox (58-99)
• Date: Wednesday, September 24, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and CHSN

Yankees vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-390) | CHW: (+310)
• Spread: NYY: -1.5 (-166) | CHW: +1.5 (+138)
• Total: 8 -- Over: (-120) | Under: (-102)

Yankees vs White Sox Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 18-5, 2.92 ERA vs Fraser Ellard (White Sox) - 0-2, 4.50 ERA

This contest's pitching matchup is set, as the Yankees will send Max Fried (18-5) to the mound, while Fraser Ellard (0-2) will take the ball for the White Sox. Fried and his team are 18-13-0 ATS this season when he starts. When Fried starts a game and his team is the favorite on the moneyline, they have a record of 21-10. Ellard has started two games with set spreads, and the White Sox covered in both opportunities. The White Sox were named the moneyline underdog for two Ellard starts this season -- they won both.

Yankees vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (73.8%)

Yankees vs White Sox Moneyline

• Looking at the moneyline for White Sox-Yankees, Chicago is the underdog at +310, and New York is -390 playing at home.

Yankees vs White Sox Spread

• The Yankees are 1.5-run home favorites on the runline against the White Sox. The Yankees are -166 to cover, and the White Sox are +138.

Yankees vs White Sox Over/Under

• An over/under of 8 has been set for Yankees-White Sox on Sept. 24, with the over being -120 and the under -102.

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Yankees vs White Sox Betting Trends

• The Yankees have won in 80, or 60.2%, of the 133 contests they have been named as odds-on favorites in this year.
• New York has not played a game this season with better moneyline odds than -390.
• The Yankees and their opponents have gone over the total this season in 74 of their 155 opportunities.
• The Yankees are 72-83-0 against the spread in their 155 games that had a posted line this season.
• The White Sox are 54-94 in games they were listed as the moneyline underdog (winning 36.5% of those games).
• Chicago has not yet played a game with moneyline odds of +310 or longer.
• The White Sox have had an over/under set by oddsmakers 152 times, and have combined with opponents to go over the total in 69 of those games (69-75-8).
• The White Sox have covered 57.2% of their games this season, going 87-65-0 against the spread.

Yankees Player Leaders

• Aaron Judge leads New York in OBP (.452), slugging percentage (.669) and total hits (170) this season. He has a .325 batting average.
• Among qualified hitters in MLB, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Cody Bellinger is hitting .269 with 25 doubles, five triples, 29 home runs and 52 walks. He's slugging .483 with an on-base percentage of .328.
• He is 39th in batting average, 70th in on-base percentage and 27th in slugging among qualified hitters.
• Trent Grisham has 113 hits this season and has a slash line of .236/.346/.467.
• Jazz Chisholm has been key for New York with 111 hits, an OBP of .337 plus a slugging percentage of .490.
• Chisholm brings a five-game hitting streak into this game. In his last five games he is hitting .412 with a double, two home runs, two walks and four RBIs.

White Sox Player Leaders

• Miguel Vargas has put up an on-base percentage of .311, a team-high for the White Sox. He's batting .230 and slugging .397.
• Including all the qualified hitters in the majors, he ranks 132nd in batting average, 105th in on-base percentage and 105th in slugging percentage.
• Vargas brings a four-game hitting streak into this matchup. During his last five outings he is hitting .263 with a double, a home run, two walks and four RBIs.
• Lenyn Sosa leads his team with 130 hits and has a club-leading .423 slugging percentage. He has a batting average of .258 with an on-base percentage of .288.
• He is currently 71st in batting average, 134th in on-base percentage and 76th in slugging percentage among all qualifying hitters.
• Chase Meidroth is batting .262 with 15 doubles, five home runs and 45 walks.
• Mike Tauchman is batting .263 with 17 doubles, a triple, nine home runs and 45 walks.

Yankees vs White Sox Head to Head

• 9/23/2025: 3-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/31/2025: 3-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 8/30/2025: 5-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/29/2025: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/28/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/14/2024: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/13/2024: 4-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 8/12/2024: 12-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -355, Underdog Moneyline: +285)
• 5/19/2024: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/18/2024: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -295, Underdog Moneyline: +240)

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