Reds vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 6:12 p.m.

On Wednesday in MLB, the Cincinnati Reds are playing the Pittsburgh Pirates.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Pirates Game Info

• Cincinnati Reds (80-77) vs. Pittsburgh Pirates (68-89)
• Date: Wednesday, September 24, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and SportsNet PT

Reds vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-122) | PIT: (+104)
• Spread: CIN: +1.5 (-215) | PIT: -1.5 (+176)
• Total: 7 -- Over: (-102) | Under: (-120)

Reds vs Pirates Probable Starting Pitchers

Probable Pitchers: Hunter Greene (Reds) - 7-4, 2.74 ERA vs Paul Skenes (Pirates) - 10-10, 2.03 ERA

The probable starters are Hunter Greene (7-4) for the Reds and Paul Skenes (10-10) for the Pirates. When Greene starts, his team is 6-11-0 against the spread this season. When Greene starts a game and his team is the favorite on the moneyline, they have a record of 7-3. The Pirates have a 15-16-0 record against the spread in Skenes' starts. The Pirates are 5-4 in Skenes' nine starts this season that they were the underdog on the moneyline.

Reds vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (50.2%)

Reds vs Pirates Moneyline

• Cincinnati is the favorite, -122 on the moneyline, while Pittsburgh is a +104 underdog on the road.

Reds vs Pirates Spread

• The Pirates are 1.5-run favorites against the spread for this matchup with the Reds. The Pirates are +176 to cover, while the Reds are -215 to cover as a 1.5-run underdog on the runline.

Reds vs Pirates Over/Under

• The over/under for Reds-Pirates on Sept. 24 is 7. The over is -102, and the under is -120.

Bet on Cincinnati Reds vs. Pittsburgh Pirates on FanDuel today!

Reds vs Pirates Betting Trends

• The Reds have been chosen as favorites in 64 games this year and have walked away with the win 34 times (53.1%) in those games.
• Cincinnati has a record of 21-20 when favored by -122 or more this year.
• The Reds' games have gone over the total in 58 of their 149 opportunities.
• The Reds have an against the spread record of 77-72-0 in 149 games with a line this season.
• The Pirates have won 40.8% of the games this season they were the moneyline underdog (42-61).
• Pittsburgh has gone 36-53 in games it has played as a moneyline underdog with odds of +104 or longer (40.4%).
• The Pirates have played in 149 games with a set over/under, and have combined with their opponents to go over the total 57 times (57-86-6).
• The Pirates are 81-68-0 ATS this season.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 162 hits and a team-best slugging percentage of .444. He's batting .266 with an on-base percentage of .340.
• Among qualified hitters in MLB, he ranks 46th in batting average, 52nd in on-base percentage, and 62nd in slugging.
• De La Cruz has hit safely in four straight games. In his last five games he is batting .429 with a double, two home runs, four walks and three RBIs.
• TJ Friedl leads Cincinnati with an OBP of .361 this season while batting .258 with 77 walks and 79 runs scored. He's slugging .370.
• His batting average ranks 71st among qualified players, his on-base percentage 20th, and his slugging percentage 131st.
• Spencer Steer has collected 118 base hits, an OBP of .312 and a slugging percentage of .418 this season.
• Austin Hays has 15 home runs, 64 RBI and a batting average of .266 this season.

Pirates Player Leaders

• Bryan Reynolds has racked up a team-best slugging percentage (.401) and leads the Pirates in hits (138). He's batting .243 and with an on-base percentage of .315.
• Including all qualified players, he is 105th in batting average, while his on-base percentage ranks 100th and he is 99th in slugging.
• Oneil Cruz has 18 doubles, three triples, 20 home runs and 64 walks while hitting .203. He's slugging .384 with an on-base percentage of .302.
• Including all qualifying hitters, he is 145th in batting average, 118th in on-base percentage and 119th in slugging percentage.
• Andrew McCutchen a has .336 on-base percentage to pace the Pirates.
• Spencer Horwitz is hitting .257 with 23 doubles, nine home runs and 41 walks.

Reds vs Pirates Head to Head

• 9/23/2025: 4-2 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/10/2025: 14-8 CIN (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/9/2025: 2-1 CIN (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/8/2025: 3-2 PIT (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/7/2025: 7-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/21/2025: 3-1 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/20/2025: 1-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/19/2025: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/12/2025: 5-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

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