Yankees vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 7:13 p.m.

In MLB action on Tuesday, the New York Yankees face the Chicago White Sox.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs White Sox Game Info

• New York Yankees (88-68) vs. Chicago White Sox (58-98)
• Date: Tuesday, September 23, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and CHSN

Yankees vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-235) | CHW: (+194)
• Spread: NYY: -1.5 (-120) | CHW: +1.5 (-100)
• Total: 9 -- Over: (-102) | Under: (-120)

Yankees vs White Sox Probable Starting Pitchers

Probable Pitchers: Luis Gil (Yankees) - 4-1, 3.33 ERA vs Shane Smith (White Sox) - 6-8, 4.06 ERA

The probable starters are Luis Gil (4-1) for the Yankees and Shane Smith (6-8) for the White Sox. Gil's team is 5-4-0 against the spread this season in his starts. Gil's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 6-3. The White Sox have a 15-12-0 ATS record in Smith's 27 starts that had a set spread. The White Sox have been the underdog on the moneyline in 24 of Smith's starts this season, and they went 8-16 in those games.

Yankees vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (75.3%)

Yankees vs White Sox Moneyline

• Chicago is the underdog, +194 on the moneyline, while New York is a -235 favorite at home.

Yankees vs White Sox Spread

• The Yankees are hosting the White Sox and are favored by 1.5 runs (-120 to cover) on the runline. Chicago is -100 to cover.

Yankees vs White Sox Over/Under

• A combined run total of 9 has been set for Yankees-White Sox on Sept. 23, with the over at -102 and the under at -120.

Bet on New York Yankees vs. Chicago White Sox on FanDuel today!

Yankees vs White Sox Betting Trends

• The Yankees have been chosen as favorites in 132 games this year and have walked away with the win 79 times (59.8%) in those games.
• New York has a record of 9-5 when favored by -235 or more this year.
• The Yankees' games have gone over the total in 74 of their 154 opportunities.
• The Yankees have an against the spread mark of 72-82-0 in 154 games with a line this season.
• The White Sox are 54-93 in games they were the underdog on the moneyline (winning 36.7% of those games).
• Chicago has a 2-24 record (winning only 7.7% of its games) when playing as a moneyline underdog of +194 or longer.
• In the 151 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 69 times (69-74-8).
• The White Sox have an 86-65-0 record ATS this season (covering 57% of the time).

Yankees Player Leaders

• Aaron Judge leads New York in OBP (.451), slugging percentage (.672) and total hits (170) this season. He has a .326 batting average.
• Among qualifying hitters in MLB, he is first in batting average, first in on-base percentage, and first in slugging.
• Cody Bellinger is batting .271 with 25 doubles, five triples, 29 home runs and 51 walks, while slugging .486 with an on-base percentage of .329.
• He is 38th in batting average, 73rd in on-base percentage and 28th in slugging in the majors.
• Bellinger takes a two-game streak with at least one hit into this matchup. In his last five games he is hitting .211 with a home run, three walks and three RBIs.
• Trent Grisham is batting .238 with a .469 slugging percentage and 72 RBI this year.
• Jazz Chisholm has 31 home runs, 79 RBI and a batting average of .242 this season.
• Chisholm has safely hit in four games in a row. In his last five games he is batting .211 with a double, two home runs, a walk and four RBIs.

White Sox Player Leaders

• Miguel Vargas a has .311 on-base percentage to pace the White Sox. He's batting .230 while slugging .398.
• Including all qualified hitters in the big leagues, he is 133rd in batting average, 104th in on-base percentage and 104th in slugging percentage.
• Vargas hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .211 with a double, a home run, two walks and four RBIs.
• Lenyn Sosa has collected 129 hits while slugging .425. Both lead his team. He has a batting average of .259 with an on-base percentage of .289.
• Including all qualified hitters, he is 68th in batting average, 135th in on-base percentage and 75th in slugging percentage.
• Chase Meidroth is hitting .265 with 15 doubles, five home runs and 45 walks.
• Mike Tauchman is batting .263 with 17 doubles, a triple, nine home runs and 45 walks.

Yankees vs White Sox Head to Head

• 8/31/2025: 3-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 8/30/2025: 5-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/29/2025: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/28/2025: 10-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/14/2024: 10-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/13/2024: 4-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 8/12/2024: 12-2 CHW (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -355, Underdog Moneyline: +285)
• 5/19/2024: 7-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/18/2024: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 5/17/2024: 4-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -290, Underdog Moneyline: +235)

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