Yankees vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 10:11 p.m.

In MLB action on Saturday, the New York Yankees take on the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Yankees vs Orioles Game Info

• New York Yankees (91-68) vs. Baltimore Orioles (75-84)
• Date: Saturday, September 27, 2025
• Time: 1:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and MASN

Yankees vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-215) | BAL: (+180)
• Spread: NYY: -1.5 (-110) | BAL: +1.5 (-111)
• Total: 9 -- Over: (-105) | Under: (-115)

Yankees vs Orioles Probable Starting Pitchers

Probable Pitchers: Cam Schlittler (Yankees) - 3-3, 3.27 ERA vs Tomoyuki Sugano (Orioles) - 10-9, 4.54 ERA

The probable pitchers are Cam Schlittler (3-3) for the Yankees and Tomoyuki Sugano (10-9) for the Orioles. Schlittler and his team have a record of 6-6-0 against the spread when he starts. Schlittler's team has won 66.7% of his starts when they are favored on the moneyline (6-3). The Orioles have a 16-13-0 record against the spread in Sugano's starts. The Orioles have been the underdog on the moneyline in 19 of Sugano's starts this season, and they went 10-9 in those games.

Yankees vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (68.1%)

Yankees vs Orioles Moneyline

• The Yankees vs Orioles moneyline has New York as a -215 favorite, while Baltimore is a +180 underdog on the road.

Yankees vs Orioles Spread

• The Orioles are +1.5 on the run line against the Yankees. The Orioles are -111 to cover, and the Yankees are -110.

Yankees vs Orioles Over/Under

• Yankees versus Orioles on Sept. 27 has an over/under of 9 runs, with the odds on the over -105 and the under set at -115.

Bet on New York Yankees vs. Baltimore Orioles on FanDuel today!

Yankees vs Orioles Betting Trends

• The Yankees have been victorious in 82, or 60.7%, of the 135 contests they have been chosen as favorites in this season.
• This season New York has come away with a win 17 times in 25 chances when named as a favorite of at least -215 on the moneyline.
• The Yankees and their opponents have gone over the total this season in 75 of their 157 opportunities.
• The Yankees are 74-83-0 against the spread in their 157 games with a line set by sportsbooks this season.
• The Orioles have won 45.6% of the games this season they were the moneyline underdog (41-49).
• Baltimore has gone 3-1 in games it has played as a moneyline underdog with odds of +180 or longer (75%).
• The Orioles have combined with opponents to go over the total 64 times this season for a 64-87-5 record against the over/under.
• The Orioles have gone 75-81-0 ATS this season.

Yankees Player Leaders

• Aaron Judge leads New York with 175 hits and an OBP of .457, plus a team-best slugging percentage of .683. He's batting .330.
• Among qualified hitters in MLB, he is first in batting average, first in on-base percentage, and first in slugging.
• Judge has recorded a base hit in two straight games. In his last five games he is batting .412 with a double, three home runs, seven walks and five RBIs.
• Cody Bellinger has 25 doubles, five triples, 29 home runs and 55 walks. He's batting .269 and slugging .480 with an on-base percentage of .331.
• He is 43rd in batting average, 70th in on-base percentage and 30th in slugging among qualified hitters.
• Bellinger heads into this matchup looking to extend his two-game hit streak. In his last five games he is batting .211 with five walks.
• Trent Grisham is batting .237 with a .469 slugging percentage and 74 RBI this year.
• Grisham brings a two-game hitting streak into this game. During his last five outings he is batting .190 with a home run, five walks and three RBIs.
• Jazz Chisholm has 31 home runs, 80 RBI and a batting average of .245 this season.

Orioles Player Leaders

• Gunnar Henderson has put up a team-best OBP (.348) and slugging percentage (.435), while leading the Orioles in hits (155, while batting .274).
• He ranks 33rd in batting average, 41st in on-base percentage and 69th in slugging percentage among all qualified hitters in the big leagues.
• Jackson Holliday is hitting .245 with 21 doubles, three triples, 17 home runs and 54 walks. He's slugging .381 with an on-base percentage of .316.
• His batting average is 101st among all qualified players, his on-base percentage ranks 102nd, and he is 122nd in slugging.
• Jordan Westburg has 10 doubles, a triple, 15 home runs and 17 walks while hitting .260.
• Adley Rutschman is batting .225 with 16 doubles, two triples, nine home runs and 38 walks.

Yankees vs Orioles Head to Head

• 9/21/2025: 7-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/20/2025: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/19/2025: 4-2 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/18/2025: 7-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/22/2025: 4-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/21/2025: 9-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/20/2025: 5-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 4/30/2025: 5-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/29/2025: 15-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/28/2025: 4-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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