Yankees vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 1:11 p.m.

The Saturday schedule in MLB includes a matchup between the New York Yankees and the Baltimore Orioles.

We've got you covered, in terms of the most important info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Orioles Game Info

• New York Yankees (92-68) vs. Baltimore Orioles (75-85)
• Date: Saturday, September 27, 2025
• Time: 1:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: YES and MASN

Yankees vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-240) | BAL: (+198)
• Spread: NYY: -1.5 (-118) | BAL: +1.5 (-102)
• Total: 9 -- Over: (-105) | Under: (-115)

Yankees vs Orioles Probable Starting Pitchers

Probable Pitchers: Cam Schlittler (Yankees) - 3-3, 3.27 ERA vs Tomoyuki Sugano (Orioles) - 10-9, 4.54 ERA

The probable pitchers are Cam Schlittler (3-3) for the Yankees and Tomoyuki Sugano (10-9) for the Orioles. Schlittler and his team are 6-6-0 ATS this season when he starts. Schlittler's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 6-3. The Orioles have gone 16-13-0 against the spread when Sugano starts. The Orioles are 10-9 in Sugano's 19 starts this season that they were the underdog on the moneyline.

Yankees vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (57.8%)

Yankees vs Orioles Moneyline

• The moneyline numbers for Yankees vs. Orioles reveal New York as the favorite (-240) and Baltimore as the underdog (+198) on the road.

Yankees vs Orioles Spread

• The Yankees are hosting the Orioles and are favored by 1.5 runs on the spread. The Yankees are -118 to cover the runline, with the Orioles being -102.

Yankees vs Orioles Over/Under

• The over/under for Yankees-Orioles on Sept. 27 is 9. The over is -105, and the under is -115.

Bet on New York Yankees vs. Baltimore Orioles on FanDuel today!

Yankees vs Orioles Betting Trends

• The Yankees have won in 83, or 61%, of the 136 contests they have been named as odds-on favorites in this year.
• New York has a record of 10-5 in contests when oddsmakers favor them by -240 or more on the moneyline.
• The Yankees and their opponents have hit the over in 76 of their 158 games with a total set by oddsmakers this season.
• The Yankees are 75-83-0 against the spread in their 158 games that had a posted line this season.
• The Orioles have been the underdog on the moneyline 91 total times this season. They've gone 41-50 in those games.
• Baltimore has played as a moneyline underdog of +198 or longer in only two games this season, which it split 1-1.
• The Orioles have played in 157 games with an over/under set, and have combined with opponents to go over the total 65 times (65-87-5).
• The Orioles have put together a 75-82-0 record against the spread this season (covering 47.8% of the time).

Yankees Player Leaders

• Aaron Judge has 176 hits and an OBP of .458 to go with a slugging percentage of .687. All three of those stats are tops among New York hitters this season. He has a .330 batting average, as well.
• Among all qualified hitters in baseball, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Judge has recorded at least one hit in three straight games. During his last five outings he is hitting .375 with a double, three home runs, eight walks and six RBIs.
• Cody Bellinger is hitting .272 with 25 doubles, five triples, 29 home runs and 57 walks. He's slugging .482 with an on-base percentage of .335.
• He is 38th in batting average, 60th in on-base percentage and 27th in slugging in MLB.
• Bellinger heads into this matchup looking to extend his three-game hit streak. In his last five games he is batting .278 with six walks.
• Trent Grisham has 116 hits this season and has a slash line of .238/.350/.470.
• Grisham heads into this game with three games in a row with at least one hit. During his last five outings he is hitting .176 with a home run, six walks and two RBIs.
• Jazz Chisholm has 31 home runs, 80 RBI and a batting average of .244 this season.

Orioles Player Leaders

• Gunnar Henderson has accumulated a team-best OBP (.347) and slugging percentage (.433), while leading the Orioles in hits (156, while batting .273).
• Including all the qualified hitters in MLB, he is 35th in batting average, 44th in on-base percentage and 73rd in slugging percentage.
• Jackson Holliday has 21 doubles, three triples, 17 home runs and 56 walks while hitting .244. He's slugging .379 with an on-base percentage of .317.
• Including all qualified hitters, his batting average places him 104th, his on-base percentage is 101st, and he is 125th in slugging.
• Jordan Westburg is batting .266 with 10 doubles, a triple, 16 home runs and 17 walks.
• Adley Rutschman is batting .223 with 16 doubles, two triples, nine home runs and 39 walks.

Yankees vs Orioles Head to Head

• 9/26/2025: 8-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/21/2025: 7-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/20/2025: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/19/2025: 4-2 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/18/2025: 7-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/22/2025: 4-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/21/2025: 9-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/20/2025: 5-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 4/30/2025: 5-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/29/2025: 15-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

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