Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 11:11 p.m.

The Chicago Cubs will take on the St. Louis Cardinals in MLB action on Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Cubs vs Cardinals Game Info

• Chicago Cubs (90-70) vs. St. Louis Cardinals (78-82)
• Date: Saturday, September 27, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and FDSMW

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-168) | STL: (+142)
• Spread: CHC: -1.5 (+126) | STL: +1.5 (-152)
• Total: 9 -- Over: (-122) | Under: (-100)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 10-7, 3.78 ERA vs Michael McGreevy (Cardinals) - 8-3, 4.35 ERA

The probable starters are Jameson Taillon (10-7) for the Cubs and Michael McGreevy (8-3) for the Cardinals. When Taillon starts, his team is 10-10-0 against the spread this season. Taillon's team has a record of 9-4 this season when he starts and they are the favorite on the moneyline. When McGreevy starts, the Cardinals have gone 9-6-0 against the spread. The Cardinals have a 7-2 record in McGreevy's nine starts this season when they were the underdog on the moneyline.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (64%)

Cubs vs Cardinals Moneyline

• Chicago is a -168 favorite on the moneyline, while St. Louis is a +142 underdog on the road.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the spread (-152 to cover), and Chicago is +126 to cover the runline.

Cubs vs Cardinals Over/Under

• The over/under for the Cubs versus Cardinals game on Sept. 27 has been set at 9, with -122 odds on the over and -100 odds on the under.

Bet on Chicago Cubs vs. St. Louis Cardinals on FanDuel today!

Cubs vs Cardinals Betting Trends

• The Cubs have been victorious in 68, or 64.2%, of the 106 contests they have been chosen as favorites in this season.
• Chicago has a record of 25-12 in contests when oddsmakers favor them by -168 or more on the moneyline.
• The Cubs and their opponents have gone over the total this season in 73 of their 155 opportunities.
• The Cubs are 73-82-0 against the spread in their 155 games with a line set by sportsbooks this season.
• The Cardinals have won 43 of the 88 games they were the moneyline underdog this season (48.9%).
• St. Louis has gone 5-15 when playing as a moneyline underdog with odds of +142 or longer (25%).
• The Cardinals have combined with opponents to go over the total 79 times this season for a 79-70-5 record against the over/under.
• The Cardinals are 78-76-0 ATS this season.

Cubs Player Leaders

• Kyle Tucker has 133 hits this season and a team-best OBP of .382. He has a .270 batting average and a slugging percentage of .471.
• Among all qualifying hitters, he ranks 41st in batting average, his on-base percentage ranks seventh, and he is 40th in slugging.
• Tucker hopes to build on a two-game hitting streak in this matchup. In his last five games he is batting .421 with two doubles, a home run, two walks and four RBIs.
• Nico Hoerner has hit seven homers this season while driving in 61 runs. He's batting .300 this season and slugging .398 with an on-base percentage of .348.
• Among all qualified, he is seventh in batting average, 41st in on-base percentage and 107th in slugging percentage.
• Pete Crow-Armstrong is batting .245 with a .476 slugging percentage and 93 RBI this year.
• Crow-Armstrong enters this matchup with two games in a row with at least one hit. During his last five outings he is batting .200 with a home run and three RBIs.
• Seiya Suzuki is batting .244 with a .323 OBP and 101 RBI for Chicago this season.
• Suzuki has safely hit in five games in a row. In his last five games he is hitting .286 with a double, three home runs and 10 RBIs.

Cardinals Player Leaders

• Alec Burleson has totaled 144 hits with a .462 slugging percentage, both team-high numbers for the Cardinals. He's batting .292 and with an on-base percentage of .345.
• He is 13th in batting average, 46th in on-base percentage and 46th in slugging percentage among all qualified hitters in the majors.
• Brendan Donovan paces his team with a .353 OBP. He has a batting average of .287 while slugging .422.
• His batting average ranks 17th among all qualified players, his on-base percentage is 33rd, and he is 80th in slugging.
• Ivan Herrera has 13 doubles, 19 home runs and 43 walks while hitting .287.
• Lars Nootbaar has 24 doubles, a triple, 13 home runs and 63 walks while hitting .235.

Cubs vs Cardinals Head to Head

• 9/26/2025: 12-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!