Yankees vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 7:12 p.m.

The New York Yankees will take on the Baltimore Orioles in MLB action on Friday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Yankees vs Orioles Game Info

• New York Yankees (91-68) vs. Baltimore Orioles (75-84)
• Date: Friday, September 26, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: MLB Network, YES, and MASN

Yankees vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-142) | BAL: (+120)
• Spread: NYY: -1.5 (+146) | BAL: +1.5 (-178)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Yankees vs Orioles Probable Starting Pitchers

Probable Pitchers: Will Warren (Yankees) - 8-8, 4.35 ERA vs Trevor Rogers (Orioles) - 9-2, 1.35 ERA

The probable starters are Will Warren (8-8) for the Yankees and Trevor Rogers (9-2) for the Orioles. Warren's team is 12-20-0 against the spread in his starts this season. Warren's team has won 57.7% of his starts when they are favored on the moneyline (15-11). When Rogers starts, the Orioles have gone 12-4-0 against the spread. The Orioles are 7-3 in Rogers' 10 starts this season that they were the moneyline underdog.

Yankees vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (68.1%)

Yankees vs Orioles Moneyline

• The Yankees vs Orioles moneyline has New York as a -142 favorite, while Baltimore is a +120 underdog on the road.

Yankees vs Orioles Spread

• The Orioles are at +1.5 on the runline against the Yankees. The Orioles are -178 to cover the spread, and the Yankees are +146.

Yankees vs Orioles Over/Under

• The Yankees-Orioles contest on Sept. 26 has been given an over/under of 8.5 runs. The over is set at -105 and the under at -115.

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Yankees vs Orioles Betting Trends

• The Yankees have been favorites in 135 games this season and have come away with the win 82 times (60.7%) in those contests.
• This year New York has won 63 of 98 games when listed as at least -142 on the moneyline.
• Contests with the Yankees have gone over the total set by sportsbooks in 75 of 157 chances this season.
• The Yankees are 74-83-0 against the spread in their 157 games that had a posted line this season.
• The Orioles are 41-49 in games they were listed as the moneyline underdog (winning 45.6% of those games).
• Baltimore is 17-22 (winning 43.6% of its games) when it has played as a moneyline underdog of +120 or longer.
• The Orioles have played in 156 games with an over/under set, and have combined with opponents to go over the total 64 times (64-87-5).
• The Orioles have a 75-81-0 record ATS this season (covering 48.1% of the time).

Yankees Player Leaders

• Aaron Judge leads New York with 175 hits and an OBP of .457, plus a team-best slugging percentage of .683. He's batting .330.
• He ranks first in batting average, first in on-base percentage, and first in slugging among all qualifying hitters in baseball.
• Judge will look for his third straight game with a hit in this contest. In his last five games he is hitting .412 with a double, three home runs, seven walks and five RBIs.
• Cody Bellinger is hitting .269 with 25 doubles, five triples, 29 home runs and 55 walks. He's slugging .480 with an on-base percentage of .331.
• His batting average is 43rd among qualified players, his on-base percentage 70th, and his slugging percentage 30th.
• Bellinger heads into this game looking to extend his two-game hit streak. During his last five outings he is batting .211 with five walks.
• Trent Grisham has 115 hits this season and has a slash line of .237/.347/.469.
• Grisham heads into this game with two games in a row with at least one hit. During his last five outings he is hitting .190 with a home run, five walks and three RBIs.
• Jazz Chisholm has 31 home runs, 80 RBI and a batting average of .245 this season.

Orioles Player Leaders

• Gunnar Henderson has accumulated an on-base percentage of .348, a slugging percentage of .435, and has 155 hits, all club-highs for the Orioles (while batting .274).
• Including all qualified players, he ranks 33rd in batting average, while his on-base percentage is 41st and he is 69th in slugging.
• Jackson Holliday is hitting .245 with 21 doubles, three triples, 17 home runs and 54 walks. He's slugging .381 with an on-base percentage of .316.
• His batting average ranks 101st among all qualified players, his on-base percentage is 102nd, and he is 122nd in slugging.
• Jordan Westburg is hitting .260 with 10 doubles, a triple, 15 home runs and 17 walks.
• Adley Rutschman is batting .225 with 16 doubles, two triples, nine home runs and 38 walks.

Yankees vs Orioles Head to Head

• 9/21/2025: 7-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/20/2025: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/19/2025: 4-2 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/18/2025: 7-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/22/2025: 4-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/21/2025: 9-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/20/2025: 5-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 4/30/2025: 5-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/29/2025: 15-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/28/2025: 4-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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