Yankees vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 4:13 a.m.

In MLB action on Friday, the New York Yankees face the Baltimore Orioles.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs Orioles Game Info

• New York Yankees (91-68) vs. Baltimore Orioles (75-84)
• Date: Friday, September 26, 2025
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: MLB Network, YES, and MASN

Yankees vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-152) | BAL: (+128)
• Spread: NYY: -1.5 (+142) | BAL: +1.5 (-172)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Yankees vs Orioles Probable Starting Pitchers

Probable Pitchers: Will Warren (Yankees) - 8-8, 4.35 ERA vs Trevor Rogers (Orioles) - 9-2, 1.35 ERA

The probable starters are Will Warren (8-8) for the Yankees and Trevor Rogers (9-2) for the Orioles. Warren and his team are 12-20-0 ATS this season when he starts. Warren's team has won 57.7% of his starts when they are favored on the moneyline (15-11). The Orioles have a 12-4-0 record against the spread in Rogers' starts. The Orioles have a 7-3 record in Rogers' 10 starts this season when they were the underdog on the moneyline.

Yankees vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (52.8%)

Yankees vs Orioles Moneyline

• New York is a -152 favorite on the moneyline, while Baltimore is a +128 underdog on the road.

Yankees vs Orioles Spread

• The Yankees are hosting the Orioles and are favored by 1.5 runs (+142 to cover) on the runline. Baltimore is -172 to cover.

Yankees vs Orioles Over/Under

• The Yankees-Orioles contest on Sept. 26 has been given an over/under of 8.5 runs. The over is set at -105 and the under at -115.

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Yankees vs Orioles Betting Trends

• The Yankees have been favorites in 135 games this season and have come away with the win 82 times (60.7%) in those contests.
• This year New York has won 54 of 81 games when listed as at least -152 on the moneyline.
• Contests with the Yankees have gone over the total set by bookmakers in 75 of 157 chances this season.
• The Yankees are 74-83-0 against the spread in their 157 games with a line set by sportsbooks this season.
• The Orioles have gone 41-49 in games they were the underdog on the moneyline (winning 45.6% of those games).
• Baltimore is 11-20 (winning only 35.5% of its games) when playing as a moneyline underdog of +128 or longer.
• The Orioles have played in 156 games with a set over/under, and have combined with their opponents to go over the total 64 times (64-87-5).
• The Orioles are 75-81-0 against the spread this season.

Yankees Player Leaders

• Aaron Judge has 175 hits and an OBP of .457 to go with a slugging percentage of .683. All three of those stats rank first among New York hitters this season. He has a .330 batting average, as well.
• Among all qualifying hitters in MLB, he is first in batting average, first in on-base percentage, and first in slugging.
• Judge hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .412 with a double, three home runs, seven walks and five RBIs.
• Cody Bellinger is batting .269 with 25 doubles, five triples, 29 home runs and 55 walks, while slugging .480 with an on-base percentage of .331.
• Among all qualified, he is 43rd in batting average, 70th in on-base percentage and 30th in slugging percentage.
• Bellinger has picked up at least one hit in two straight games. In his last five games he is batting .211 with five walks.
• Trent Grisham has collected 115 base hits, an OBP of .347 and a slugging percentage of .469 this season.
• Grisham enters this game with two games in a row with at least one hit. In his last five games he is batting .190 with a home run, five walks and three RBIs.
• Jazz Chisholm has been key for New York with 112 hits, an OBP of .334 plus a slugging percentage of .486.

Orioles Player Leaders

• Gunnar Henderson has racked up a team-best OBP (.348) and slugging percentage (.435), while pacing the Orioles in hits (155, while batting .274).
• Including all the qualified hitters in MLB, his batting average puts him 33rd, his on-base percentage is 41st, and he is 69th in slugging.
• Jackson Holliday has 21 doubles, three triples, 17 home runs and 54 walks while batting .245. He's slugging .381 with an on-base percentage of .316.
• He is currently 101st in batting average, 102nd in on-base percentage and 122nd in slugging percentage among all qualified batters.
• Jordan Westburg is batting .260 with 10 doubles, a triple, 15 home runs and 17 walks.
• Adley Rutschman has 16 doubles, two triples, nine home runs and 38 walks while batting .225.

Yankees vs Orioles Head to Head

• 9/21/2025: 7-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/20/2025: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/19/2025: 4-2 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/18/2025: 7-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/22/2025: 4-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/21/2025: 9-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/20/2025: 5-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 4/30/2025: 5-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/29/2025: 15-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/28/2025: 4-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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