Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 9:12 p.m.

Friday's slate in the MLB includes a matchup between the San Diego Padres and the Arizona Diamondbacks.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Diamondbacks Game Info

• San Diego Padres (87-72) vs. Arizona Diamondbacks (80-79)
• Date: Friday, September 26, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and ARID

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-144) | ARI: (+122)
• Spread: SD: -1.5 (+146) | ARI: +1.5 (-178)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 4-5, 5.51 ERA vs Zac Gallen (Diamondbacks) - 13-14, 4.70 ERA

The Padres will call on Yu Darvish (4-5) versus the Diamondbacks and Zac Gallen (13-14). Darvish and his team have a record of 9-4-0 against the spread when he starts. Darvish's team has been victorious in 71.4% of the games he's started as the moneyline favorite with a record of 5-2. The Diamondbacks have a 15-17-0 ATS record in Gallen's 32 starts that had a set spread. The Diamondbacks are 7-6 in Gallen's 13 starts this season that they were the moneyline underdog.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.1%)

Padres vs Diamondbacks Moneyline

• San Diego is a -144 favorite on the moneyline, while Arizona is a +122 underdog on the road.

Padres vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the spread (-178 to cover), and San Diego is +146 to cover the runline.

Padres vs Diamondbacks Over/Under

• The over/under for the Padres versus Diamondbacks game on Sept. 26 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

Bet on San Diego Padres vs. Arizona Diamondbacks on FanDuel today!

Padres vs Diamondbacks Betting Trends

• The Padres have been favorites in 86 games this season and have come away with the win 51 times (59.3%) in those contests.
• This year San Diego has won 32 of 54 games when listed as at least -144 on the moneyline.
• The Padres and their opponents have hit the over in 68 of their 157 games with a total set by oddsmakers this season.
• The Padres are 84-73-0 against the spread in their 157 games with a line set by sportsbooks this season.
• The Diamondbacks have been the underdog on the moneyline 67 total times this season. They've gone 33-34 in those games.
• In games it has played as a moneyline underdog with odds of +122 or longer, Arizona has a 14-10 record (winning 58.3% of its games).
• In the 155 games oddsmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 77 times (77-70-8).
• The Diamondbacks are 78-77-0 ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .267 with 27 doubles, two triples, 23 home runs and 88 walks. He has an on-base percentage of .367 while slugging .438.
• Among all qualifying hitters in the majors, his batting average ranks 45th, his on-base percentage ranks 12th, and he is 68th in slugging.
• Tatis hopes to build on a five-game hitting streak in this matchup. In his last five games he is batting .381 with a home run, two walks and an RBI.
• Manny Machado has 166 hits, which leads San Diego batters this season. He's batting .273 with 59 extra-base hits. He's also slugging .455 with an on-base percentage of .332.
• Among all qualifying players, he ranks 36th in batting average, 67th in on-base percentage and 55th in slugging percentage.
• Luis Arraez has hit eight homers with a team-high .388 SLG this season.
• Arraez brings a 13-game hitting streak into this matchup. In his last 10 outings he is hitting .333 with a home run, four walks and six RBIs.
• Ramon Laureano has 24 home runs, 76 RBI and a batting average of .281 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has an on-base percentage of .390 and a slugging percentage of .457. Both lead the Diamondbacks. He's batting .289.
• Including all the qualified hitters in MLB, he is 15th in batting average, fourth in on-base percentage and 52nd in slugging percentage.
• Corbin Carroll's 146 hits pace his team. He has a batting average of .260 while slugging .544 with an on-base percentage of .342.
• Including all qualified players, he ranks 66th in batting average, 53rd in on-base percentage and seventh in slugging percentage.
• Ketel Marte has 28 doubles, 26 home runs and 63 walks while batting .283.
• Gabriel Moreno has 12 doubles, a triple, nine home runs and 27 walks while batting .284.

Padres vs Diamondbacks Head to Head

• 8/6/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 10-5 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2025: 6-3 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/15/2025: 8-2 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/14/2025: 8-7 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/13/2025: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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