Padres vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 5:14 a.m.

The MLB's Friday slate includes the San Diego Padres taking on the Arizona Diamondbacks.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Diamondbacks Game Info

• San Diego Padres (87-72) vs. Arizona Diamondbacks (80-79)
• Date: Friday, September 26, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and ARID

Padres vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-142) | ARI: (+120)
• Spread: SD: -1.5 (+152) | ARI: +1.5 (-184)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Padres vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 4-5, 5.51 ERA vs Zac Gallen (Diamondbacks) - 13-14, 4.70 ERA

The Padres will give the nod to Yu Darvish (4-5) versus the Diamondbacks and Zac Gallen (13-14). Darvish and his team are 9-4-0 ATS this season when he starts. Darvish's team has won 71.4% of his starts when they are favored on the moneyline (5-2). The Diamondbacks have a 15-17-0 ATS record in Gallen's 32 starts that had a set spread. The Diamondbacks have a 7-6 record in Gallen's 13 starts this season when they were the moneyline underdog.

Padres vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56%)

Padres vs Diamondbacks Moneyline

• The Padres vs Diamondbacks moneyline has San Diego as a -142 favorite, while Arizona is a +120 underdog on the road.

Padres vs Diamondbacks Spread

• The Padres are hosting the Diamondbacks and are favored by 1.5 runs on the spread. The Padres are +152 to cover the runline, with the Diamondbacks being -184.

Padres vs Diamondbacks Over/Under

• Padres versus Diamondbacks on Sept. 26 has an over/under of 7.5 runs, with the odds on the over -122 and the under set at -100.

Bet on San Diego Padres vs. Arizona Diamondbacks on FanDuel today!

Padres vs Diamondbacks Betting Trends

• The Padres have come away with 51 wins in the 86 contests they have been listed as the favorites in this season.
• This year San Diego has won 34 of 59 games when listed as at least -142 on the moneyline.
• Contests with the Padres have gone over the total set by bookmakers in 68 of 157 chances this season.
• The Padres are 84-73-0 against the spread in their 157 games that had a posted line this season.
• The Diamondbacks have been the underdog on the moneyline 67 total times this season. They've finished 33-34 in those games.
• Arizona has a 15-10 record (winning 60% of its games) when it has played as a moneyline underdog of +120 or longer.
• In the 155 games oddsmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 77 times (77-70-8).
• The Diamondbacks have covered 50.3% of their games this season, going 78-77-0 against the spread.

Padres Player Leaders

• Fernando Tatis Jr. has 27 doubles, two triples, 23 home runs and 88 walks while hitting .267. He has an on-base percentage of .367 and a slugging percentage of .438.
• Among qualifying hitters in baseball, he ranks 45th in batting average, 12th in on-base percentage, and 68th in slugging.
• Tatis has picked up at least one hit in five straight games. In his last five games he is batting .381 with a home run, two walks and an RBI.
• Manny Machado leads San Diego in total hits (166) this season while batting .273 with 59 extra-base hits. He's slugging .455 with an on-base percentage of .332.
• Among qualifying batters, he is 36th in batting average, 67th in on-base percentage and 55th in slugging percentage.
• Luis Arraez has hit eight homers with a team-high .388 SLG this season.
• Arraez enters this matchup with 13 games in a row with at least one hit. In his last 10 outings he is batting .333 with a home run, four walks and six RBIs.
• Ramon Laureano has 24 home runs, 76 RBI and a batting average of .281 this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has put up an on-base percentage of .390 and a slugging percentage of .457. Both lead the Diamondbacks. He's batting .289.
• Including all qualifying hitters in MLB, he is 15th in batting average, fourth in on-base percentage and 52nd in slugging percentage.
• Corbin Carroll paces his team with 146 hits. He has a batting average of .260 while slugging .544 with an on-base percentage of .342.
• He is currently 66th in batting average, 53rd in on-base percentage and seventh in slugging percentage among all qualifying hitters.
• Ketel Marte is hitting .283 with 28 doubles, 26 home runs and 63 walks.
• Gabriel Moreno has 12 doubles, a triple, nine home runs and 27 walks while batting .284.

Padres vs Diamondbacks Head to Head

• 8/6/2025: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 10-5 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/4/2025: 6-2 ARI (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/10/2025: 4-3 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/9/2025: 8-2 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/8/2025: 1-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/7/2025: 6-3 ARI (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/15/2025: 8-2 SD (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/14/2025: 8-7 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/13/2025: 5-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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