Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 2:15 p.m.

The MLB's Friday schedule includes the Chicago Cubs facing the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Cardinals Game Info

• Chicago Cubs (89-70) vs. St. Louis Cardinals (78-81)
• Date: Friday, September 26, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and FDSMW

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-180) | STL: (+152)
• Spread: CHC: -1.5 (+106) | STL: +1.5 (-128)
• Total: 9 -- Over: (-102) | Under: (-120)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 10-7, 4.10 ERA vs Miles Mikolas (Cardinals) - 8-10, 4.76 ERA

The Cubs will give the nod to Colin Rea (10-7, 4.10 ERA), who is eyeing win No. 11 on the season, and the Cardinals will turn to Miles Mikolas (8-10, 4.76 ERA). Rea and his team have a record of 16-9-0 against the spread when he starts. When Rea starts a game and his team is the favorite on the moneyline, they have a record of 9-6. When Mikolas starts, the Cardinals are 14-16-0 against the spread. The Cardinals have been the moneyline underdog in 22 of Mikolas' starts this season, and they went 9-13 in those matchups.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (64.4%)

Cubs vs Cardinals Moneyline

• Looking at the moneyline for Cubs-Cardinals, Chicago is the favorite at -180, and St. Louis is +152 playing on the road.

Cubs vs Cardinals Spread

• The Cubs are 1.5-run home favorites on the runline against the Cardinals. The Cubs are +106 to cover, and the Cardinals are -128.

Cubs vs Cardinals Over/Under

• Cubs versus Cardinals on Sept. 26 has an over/under of 9 runs, with the odds on the over -102 and the under set at -120.

Bet on Chicago Cubs vs. St. Louis Cardinals on FanDuel today!

Cubs vs Cardinals Betting Trends

• The Cubs have been victorious in 67, or 63.8%, of the 105 contests they have been chosen as favorites in this season.
• This season Chicago has come away with a win 19 times in 27 chances when named as a favorite of at least -180 on the moneyline.
• The Cubs and their opponents have gone over the total this season in 72 of their 154 opportunities.
• The Cubs are 72-82-0 against the spread in their 154 games that had a posted line this season.
• The Cardinals are 43-44 in games they were the underdog on the moneyline (winning 49.4% of those games).
• In games it has played as a moneyline underdog with odds of +152 or longer, St. Louis has gone 4-13 (23.5%).
• The Cardinals have played in 153 games with a set over/under, and have combined with opponents to go over the total 78 times (78-70-5).
• The Cardinals have collected a 78-75-0 record against the spread this season (covering 51% of the time).

Cubs Player Leaders

• Nico Hoerner leads Chicago with a slugging percentage of .393, fueled by 39 extra-base hits. He has a .299 batting average and an on-base percentage of .348.
• He ranks eighth in batting average, 41st in on-base percentage, and 112th in slugging among all qualifying hitters in the majors.
• Pete Crow-Armstrong is hitting .244 with 37 doubles, four triples, 29 home runs and 29 walks, while slugging .472 with an on-base percentage of .284.
• Among all qualifying hitters, he is 106th in batting average, 140th in on-base percentage and 40th in slugging percentage.
• Ian Happ has collected 135 base hits, an OBP of .343 and a slugging percentage of .422 this season.
• Happ has logged a hit or more in four straight games. In his last five games he is batting .211 with three doubles, two walks and four RBIs.
• Seiya Suzuki is batting .244 with a .323 OBP and 97 RBI for Chicago this season.
• Suzuki takes a four-game hitting streak into this matchup. In his last five games he is hitting .278 with a double, two home runs and six RBIs.

Cardinals Player Leaders

• Alec Burleson has racked up a team-high slugging percentage (.464) while pacing the Cardinals in hits (144). He's batting .293 and with an on-base percentage of .345.
• Including all qualified players in MLB, he ranks 12th in batting average, 47th in on-base percentage and 44th in slugging percentage.
• Burleson enters this game on a nine-game hitting streak. During his last 10 games he is batting .421 with four doubles, a home run, three walks and six RBIs.
• Brendan Donovan leads his team with a .353 on-base percentage. He has a batting average of .287 while slugging .422.
• Including all qualifying hitters, he is 17th in batting average, 33rd in on-base percentage and 78th in slugging percentage.
• Ivan Herrera is hitting .286 with 13 doubles, 19 home runs and 43 walks.
• Lars Nootbaar has 24 doubles, a triple, 13 home runs and 62 walks while hitting .237.

Cubs vs Cardinals Head to Head

• 8/9/2025: 9-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/8/2025: 5-0 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 7/5/2025: 8-6 STL (Favorite: Cubs, Spread: -1.5, Total: 11, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/4/2025: 11-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/26/2025: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/25/2025: 8-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!