Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 5:14 a.m.

On Friday in MLB, the Houston Astros are playing the Los Angeles Angels.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Angels Game Info

• Houston Astros (85-74) vs. Los Angeles Angels (71-88)
• Date: Friday, September 26, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-154) | LAA: (+130)
• Spread: HOU: -1.5 (+106) | LAA: +1.5 (-128)
• Total: 9 -- Over: (-105) | Under: (-115)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Jason Alexander (Astros) - 4-2, 4.83 ERA vs Kyle Hendricks (Angels) - 8-10, 4.79 ERA

The Astros will give the nod to Jason Alexander (4-2, 4.83 ERA), who is eyeing win No. 5 on the season, and the Angels will counter with Kyle Hendricks (8-10, 4.79 ERA). Alexander and his team are 8-4-0 ATS this season when he starts. Alexander's team is 5-1 this season when he starts and they are the moneyline favorite. The Angels have a 20-10-0 ATS record in Hendricks' 30 starts with a set spread. The Angels have been the underdog on the moneyline in 25 of Hendricks' starts this season, and they went 11-14 in those games.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.2%)

Astros vs Angels Moneyline

• Los Angeles is the underdog, +130 on the moneyline, while Houston is a -154 favorite despite being on the road.

Astros vs Angels Spread

• The Astros are 1.5-run road favorites on the runline against the Angels. The Astros are +106 to cover, and the Angels are -128.

Astros vs Angels Over/Under

• The over/under for the Astros versus Angels game on Sept. 26 has been set at 9, with -105 odds on the over and -115 odds on the under.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have come away with 51 wins in the 96 contests they have been listed as the favorites in this season.
• Houston has a record of 18-15 in contests when bookmakers favor them by -154 or more on the moneyline.
• The Astros and their opponents have hit the over in 72 of their 158 games with a total set by oddsmakers this season.
• The Astros have posted a record of 78-80-0 against the spread this season.
• The Angels have a 51-67 record in games they were listed as the moneyline underdog (winning 43.2% of those games).
• In games it has played as a moneyline underdog with odds of +130 or longer, Los Angeles has gone 26-34 (43.3%).
• The Angels have played in 157 games with an over/under set, and have combined with their opponents to go over the total 84 times (84-68-5).
• The Angels have an 82-75-0 record ATS this season (covering 52.2% of the time).

Astros Player Leaders

• Jose Altuve leads Houston with a slugging percentage of .443, fueled by 51 extra-base hits. He has a .265 batting average and an on-base percentage of .329.
• He is 52nd in batting average, 77th in on-base percentage, and 63rd in slugging among qualifying hitters in MLB.
• Altuve will look for his third straight game with a hit in this contest. In his last five games he is hitting .412 with two doubles, three walks and three RBIs.
• Jeremy Pena has 150 hits and an OBP of .363, both of which lead the Astros this season. He's batting .304 and slugging .477.
• Among qualified hitters, his batting average ranks him fifth, his on-base percentage 16th, and his slugging percentage 32nd.
• Yainer Diaz is batting .253 with a .408 slugging percentage and 68 RBI this year.
• Carlos Correa is batting .274 with a .332 OBP and 52 RBI for Houston this season.
• Correa heads into this game on a two-game hitting streak. During his last five outings he is hitting .222 with two doubles, four walks and two RBIs.

Angels Player Leaders

• Taylor Ward has a team-high .477 slugging percentage. He's batting .228 with an on-base percentage of .315.
• Including all the qualifying players in the big leagues, he ranks 137th in batting average, 104th in on-base percentage and 32nd in slugging percentage.
• Ward enters this game on a seven-game hitting streak. In his last 10 outings he is batting .282 with six home runs and six RBIs.
• Jo Adell's 122 hits lead his team. He has a batting average of .237 while slugging .490 with an on-base percentage of .296.
• He is 118th in batting average, 126th in on-base percentage and 21st in slugging percentage in the majors.
• Nolan Schanuel a has .355 on-base percentage to lead the Angels.
• Mike Trout has a .355 OBP to lead his team.

Astros vs Angels Head to Head

• 9/1/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/31/2025: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/30/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/22/2025: 8-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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