Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 26

Odds updated as of 9:12 p.m.

The Houston Astros are among the MLB squads playing on Friday, up against the Los Angeles Angels.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Astros vs Angels Game Info

• Houston Astros (85-74) vs. Los Angeles Angels (71-88)
• Date: Friday, September 26, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and SCHN

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-154) | LAA: (+130)
• Spread: HOU: -1.5 (+106) | LAA: +1.5 (-128)
• Total: 9 -- Over: (-105) | Under: (-115)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Jason Alexander (Astros) - 4-2, 4.83 ERA vs Kyle Hendricks (Angels) - 8-10, 4.79 ERA

This contest's pitching matchup is set, as the Astros will send Jason Alexander (4-2) to the mound, while Kyle Hendricks (8-10) will take the ball for the Angels. Alexander's team is 8-4-0 against the spread in his starts this season. Alexander's team has a record of 5-1 this season when he starts and they are the favorite on the moneyline. The Angels have gone 20-10-0 ATS in Hendricks' 30 starts that had a set spread. The Angels are 11-14 in Hendricks' 25 starts this season that they were the moneyline underdog.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.4%)

Astros vs Angels Moneyline

• The moneyline numbers for Astros vs. Angels reveal Houston as the favorite (-154) and Los Angeles as the underdog (+130) despite being the home team.

Astros vs Angels Spread

• The Astros are 1.5-run road favorites on the runline against the Angels. The Astros are +106 to cover, and the Angels are -128.

Astros vs Angels Over/Under

• The Astros-Angels contest on Sept. 26 has been given an over/under of 9 runs. The over is set at -105 and the under at -115.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have been favorites in 96 games this season and have come away with the win 51 times (53.1%) in those contests.
• This season Houston has been victorious 18 times in 33 chances when named as a favorite of at least -154 on the moneyline.
• Contests with the Astros have gone over the total set by sportsbooks in 72 of 158 chances this season.
• The Astros are 78-80-0 against the spread in their 158 games that had a posted line this season.
• The Angels have been the moneyline underdog 118 total times this season. They've finished 51-67 in those games.
• Los Angeles has gone 26-34 when playing as a moneyline underdog with odds of +130 or longer (43.3%).
• The Angels have had an over/under set by bookmakers 157 times, and have combined with opponents to go over the total in 84 of those games (84-68-5).
• The Angels have covered 52.2% of their games this season, going 82-75-0 against the spread.

Astros Player Leaders

• Jose Altuve leads Houston in slugging percentage (.443) thanks to 51 extra-base hits. He has a .265 batting average and an on-base percentage of .329.
• Among qualified hitters, he ranks 52nd in batting average, his on-base percentage ranks 77th, and he is 63rd in slugging.
• Altuve will look for his third straight game with a hit in this matchup. During his last five outings he is hitting .412 with two doubles, three walks and three RBIs.
• Jeremy Pena leads Houston with 150 hits and an OBP of .363 this season. He's batting .304 and slugging .477.
• He is fifth in batting average, 16th in on-base percentage and 32nd in slugging among qualifying hitters.
• Yainer Diaz has 134 hits this season and has a slash line of .253/.282/.408.
• Carlos Correa has been key for Houston with 146 hits, an OBP of .332 plus a slugging percentage of .402.
• Correa brings a two-game hitting streak into this game. In his last five games he is batting .222 with two doubles, four walks and two RBIs.

Angels Player Leaders

• Taylor Ward has a slugging percentage of .477, a team-high for the Angels. He's batting .228 with an on-base percentage of .315.
• He is 137th in batting average, 104th in on-base percentage and 32nd in slugging percentage among all qualifying batters in MLB.
• Ward hopes to build on a seven-game hitting streak in this matchup. In his last 10 games he is batting .282 with six home runs and six RBIs.
• Jo Adell's 122 hits lead his team. He has a batting average of .237 while slugging .490 with an on-base percentage of .296.
• Including all qualifying hitters, he ranks 118th in batting average, 126th in on-base percentage and 21st in slugging percentage.
• Nolan Schanuel a has .355 on-base percentage to pace the Angels.
• Mike Trout has a .355 on-base percentage to pace his team.

Astros vs Angels Head to Head

• 9/1/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 8/31/2025: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/30/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/22/2025: 8-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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