Yankees vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 1:12 p.m.

The MLB's Sunday slate includes the New York Yankees facing the Baltimore Orioles.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Yankees vs Orioles Game Info

• New York Yankees (87-68) vs. Baltimore Orioles (73-82)
• Date: Sunday, September 21, 2025
• Time: 1:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and YES

Yankees vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-136) | BAL: (+116)
• Spread: NYY: -1.5 (+118) | BAL: +1.5 (-142)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Yankees vs Orioles Probable Starting Pitchers

Probable Pitchers: Cam Schlittler (Yankees) - 3-3, 3.41 ERA vs Kyle Bradish (Orioles) - 1-1, 2.45 ERA

The Yankees will give the ball to Cam Schlittler (3-3, 3.41 ERA), who is eyeing win No. 4 on the season, and the Orioles will counter with Kyle Bradish (1-1, 2.45 ERA). Schlittler and his team are 5-6-0 ATS this season when he starts. Schlittler's team is 5-3 this season when he starts and they are the moneyline favorite. The Orioles have gone 2-2-0 against the spread when Bradish starts. The Orioles were the moneyline underdog for two Bradish starts this season -- they split the games.

Yankees vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (52%)

Yankees vs Orioles Moneyline

• Baltimore is the underdog, +116 on the moneyline, while New York is a -136 favorite despite being on the road.

Yankees vs Orioles Spread

• The Orioles are hosting the Yankees, and are +1.5 on the runline. The Orioles are +118 to cover the spread, and the Yankees are -142.

Yankees vs Orioles Over/Under

• A combined run total of 8.5 has been set for Yankees-Orioles on Sept. 21, with the over at -104 and the under at -118.

Bet on New York Yankees vs. Baltimore Orioles on FanDuel today!

Yankees vs Orioles Betting Trends

• The Yankees have been favorites in 131 games this season and have come away with the win 78 times (59.5%) in those contests.
• This season New York has come away with a win 64 times in 101 chances when named as a favorite of at least -136 on the moneyline.
• Contests with the Yankees have gone over the total set by oddsmakers in 74 of 153 chances this season.
• The Yankees have posted a record of 71-82-0 against the spread this season.
• The Orioles have won 40 of the 88 games they were the underdog on the moneyline this season (45.5%).
• Baltimore has gone 18-27 when playing as a moneyline underdog with odds of +116 or longer (40%).
• The Orioles have played in 152 games with a set over/under, and have combined with opponents to go over the total 63 times (63-85-4).
• The Orioles have a 73-79-0 record against the spread this season (covering 48% of the time).

Yankees Player Leaders

• Aaron Judge has 170 hits and an OBP of .452 to go with a slugging percentage of .677. All three of those stats lead New York hitters this season. He has a .329 batting average, as well.
• Among all qualifying hitters in MLB, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Judge has hit safely in two games in a row. During his last five outings he is batting .438 with a double, a home run, five walks and three RBIs.
• Cody Bellinger has 25 doubles, five triples, 29 home runs and 51 walks. He's batting .272 and slugging .488 with an on-base percentage of .330.
• He is 36th in batting average, 69th in on-base percentage and 25th in slugging in the major leagues.
• Trent Grisham has collected 113 base hits, an OBP of .348 and a slugging percentage of .474 this season.
• Jazz Chisholm has 30 home runs, 78 RBI and a batting average of .242 this season.
• Chisholm takes a three-game hitting streak into this matchup. During his last five outings he is hitting .250 with a double, a home run and three RBIs.

Orioles Player Leaders

• Gunnar Henderson has racked up an on-base percentage of .349, a slugging percentage of .440, and has 152 hits, all club-highs for the Orioles (while batting .275).
• Including all qualifying hitters in MLB, he ranks 35th in batting average, 37th in on-base percentage and 64th in slugging percentage.
• Henderson hopes to build on a five-game hitting streak in this matchup. During his last five outings he is batting .429 with a double, a walk and three RBIs.
• Jackson Holliday is hitting .247 with 21 doubles, three triples, 17 home runs and 53 walks. He's slugging .384 with an on-base percentage of .317.
• Including all qualifying hitters, he is 94th in batting average, 99th in on-base percentage and 119th in slugging percentage.
• Jordan Westburg has nine doubles, a triple, 15 home runs and 17 walks while hitting .261.
• Ryan Mountcastle is hitting .256 with 18 doubles, six home runs and 14 walks.

Yankees vs Orioles Head to Head

• 9/20/2025: 6-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/19/2025: 4-2 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/18/2025: 7-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/22/2025: 4-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 6/21/2025: 9-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/20/2025: 5-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 4/30/2025: 5-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/29/2025: 15-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/28/2025: 4-3 BAL (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/26/2024: 10-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -164, Underdog Moneyline: +138)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!