Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 3:12 p.m.

MLB action on Sunday includes the Los Angeles Dodgers taking on the San Francisco Giants.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (88-67) vs. San Francisco Giants (76-79)
• Date: Sunday, September 21, 2025
• Time: 4:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: SportsNet LA and NBCS-BA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-245) | SF: (+200)
• Spread: LAD: -1.5 (-120) | SF: +1.5 (-100)
• Total: 8.5 -- Over: (-128) | Under: (+104)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Emmet Sheehan (Dodgers) - 6-3, 3.17 ERA vs Trevor McDonald (Giants) - 0-0, 9.00 ERA

The Dodgers will call on Emmet Sheehan (6-3) versus the Giants and Trevor McDonald. Sheehan and his team have a record of 5-5-0 against the spread when he starts. Sheehan's team is 5-4 this season when he starts and they are the moneyline favorite. McDonald and his team were moneyline underdogs every time he pitched a season ago.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (64.6%)

Dodgers vs Giants Moneyline

• Looking at the moneyline for Dodgers-Giants, Los Angeles is the favorite at -245, and San Francisco is +200 playing on the road.

Dodgers vs Giants Spread

• The Dodgers are hosting the Giants and are favored by 1.5 runs (-120 to cover) on the runline. San Francisco is -100 to cover.

Dodgers vs Giants Over/Under

• A total of 8.5 runs has been set for the Dodgers-Giants game on Sept. 21, with the over available at -128 and the under at +104.

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Dodgers vs Giants Betting Trends

• The Dodgers have come away with 78 wins in the 136 contests they have been listed as the favorites in this season.
• Los Angeles has a record of 21-6 in contests when sportsbooks favor them by -245 or more on the moneyline.
• The Dodgers' games have gone over the total in 74 of their 153 opportunities.
• In 153 games with a line this season, the Dodgers have a mark of 66-87-0 against the spread.
• The Giants have won 42.9% of the games this season they were the moneyline underdog (27-36).
• San Francisco has yet to play as a moneyline underdog of +200 or longer.
• The Giants have played in 154 games with a set over/under, and have combined with their opponents to go over the total 74 times (74-72-8).
• The Giants have put together a 72-82-0 record against the spread this season (covering 46.8% of the time).

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles in OBP (.395), slugging percentage (.623) and total hits (166) this season. He has a .283 batting average.
• He ranks 19th in batting average, third in on-base percentage, and second in slugging among qualifying batters in MLB.
• Ohtani hopes to build on an eight-game hitting streak in this matchup. In his last 10 outings he is batting .333 with three doubles, five home runs, nine walks and eight RBIs.
• Mookie Betts is hitting .260 with 23 doubles, two triples, 20 home runs and 60 walks, while slugging .414 with an on-base percentage of .330.
• His batting average ranks 65th among qualified players, his on-base percentage 69th, and his slugging percentage 85th.
• Betts heads into this game looking to extend his two-game hit streak. During his last five outings he is hitting .167 with a double, a home run, three walks and an RBI.
• Freddie Freeman has 157 hits this season and has a slash line of .292/.363/.490.
• Andy Pages is batting .278 with a .319 OBP and 82 RBI for Los Angeles this season.

Giants Player Leaders

• Rafael Devers has accumulated a team-high OBP (.370), and leads the Giants in hits (146). He's batting .251 and slugging.
• Including all the qualified hitters in MLB, his batting average is 89th, his on-base percentage is 11th, and he is 43rd in slugging.
• Jung Hoo Lee has 30 doubles, 11 triples, eight home runs and 47 walks while hitting .263. He's slugging .404 with an on-base percentage of .327.
• Including all qualifying players, he is 56th in batting average, 77th in on-base percentage and 95th in slugging percentage.
• Willy Adames has 21 doubles, two triples, 28 home runs and 78 walks while batting .227.
• Matt Chapman has 21 doubles, two triples, 21 home runs and 69 walks while batting .234.

Dodgers vs Giants Head to Head

• 9/20/2025: 7-5 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 9/19/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/18/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/14/2025: 10-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/13/2025: 13-7 LAD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/12/2025: 5-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/13/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/11/2025: 8-7 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/15/2025: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)

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