Dodgers vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 12:20 a.m.

On Sunday in MLB, the Los Angeles Dodgers are playing the San Francisco Giants.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Giants Game Info

• Los Angeles Dodgers (87-67) vs. San Francisco Giants (76-78)
• Date: Sunday, September 21, 2025
• Time: 4:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: SportsNet LA and NBCS-BA

Dodgers vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-245) | SF: (+200)
• Spread: LAD: -1.5 (-120) | SF: +1.5 (-100)
• Total: 8.5 -- Over: (-128) | Under: (+104)

Dodgers vs Giants Probable Starting Pitchers

Probable Pitchers: Emmet Sheehan (Dodgers) - 6-3, 3.17 ERA vs Trevor McDonald (Giants) - 0-0, 9.00 ERA

The probable pitchers are Emmet Sheehan (6-3) for the Dodgers and Trevor McDonald for the Giants. When Sheehan starts, his team is 5-5-0 against the spread this season. Sheehan's team has a record of 5-4 this season when he starts and they are the favorite on the moneyline. McDonald never pitched as a moneyline underdog a season ago.

Dodgers vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (66.7%)

Dodgers vs Giants Moneyline

• Los Angeles is a -245 favorite on the moneyline, while San Francisco is a +200 underdog on the road.

Dodgers vs Giants Spread

• The Dodgers are 1.5-run home favorites on the runline against the Giants. The Dodgers are -120 to cover, and the Giants are -100.

Dodgers vs Giants Over/Under

• A combined run total of 8.5 has been set for Dodgers-Giants on Sept. 21, with the over at -128 and the under at +104.

Bet on Los Angeles Dodgers vs. San Francisco Giants on FanDuel today!

Dodgers vs Giants Betting Trends

• The Dodgers have been favorites in 135 games this season and have come away with the win 77 times (57%) in those contests.
• Los Angeles has a record of 20-6 in contests when bookmakers favor them by -245 or more on the moneyline.
• The Dodgers' games have gone over the total in 73 of their 152 opportunities.
• In 152 games with a line this season, the Dodgers have a mark of 65-87-0 against the spread.
• The Giants have won 43.5% of the games this season they were the moneyline underdog (27-35).
• San Francisco has yet to play a game with moneyline odds of +200 or longer.
• The Giants have combined with opponents to hit the over on the total 73 times this season for a 73-72-8 record against the over/under.
• The Giants have put together a 72-81-0 record ATS this season (covering 47.1% of the time).

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles in OBP (.394), slugging percentage (.619) and total hits (165) this season. He has a .283 batting average.
• Among the qualified batters in the majors, his batting average ranks 19th, his on-base percentage ranks third, and he is second in slugging.
• Ohtani hopes to build on a seven-game hitting streak in this matchup. In his last 10 games he is hitting .333 with three doubles, four home runs, eight walks and eight RBIs.
• Mookie Betts has 22 doubles, two triples, 20 home runs and 58 walks. He's batting .260 and slugging .413 with an on-base percentage of .328.
• He is 65th in batting average, 76th in on-base percentage and 87th in slugging in MLB.
• Freddie Freeman has 156 hits this season and has a slash line of .293/.362/.492.
• Andy Pages has been key for Los Angeles with 154 hits, an OBP of .321 plus a slugging percentage of .470.

Giants Player Leaders

• Rafael Devers has an on-base percentage of .371 and has 145 hits, both team-high numbers for the Giants. He's batting .251 and slugging .466.
• He is 89th in batting average, 11th in on-base percentage and 44th in slugging percentage among all qualifying batters in the big leagues.
• Jung Hoo Lee is hitting .261 with 30 doubles, 11 triples, eight home runs and 47 walks. He's slugging .403 with an on-base percentage of .325.
• Including all qualifying players, his batting average places him 60th, his on-base percentage is 80th, and he is 95th in slugging.
• Willy Adames is batting .226 with 21 doubles, two triples, 28 home runs and 76 walks.
• Heliot Ramos' .394 slugging percentage paces his team.

Dodgers vs Giants Head to Head

• 9/19/2025: 6-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/18/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/14/2025: 10-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/13/2025: 13-7 LAD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/12/2025: 5-1 SF (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/13/2025: 5-2 LAD (Favorite: Dodgers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2025: 2-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/11/2025: 8-7 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/15/2025: 5-4 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/14/2025: 11-5 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -180, Underdog Moneyline: +152)

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