Phillies vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 3:12 p.m.

The Arizona Diamondbacks are among the MLB teams playing on Sunday, up against the Philadelphia Phillies.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Diamondbacks vs Phillies Game Info

• Arizona Diamondbacks (78-77) vs. Philadelphia Phillies (92-63)
• Date: Sunday, September 21, 2025
• Time: 4:10 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NBCS-PH

Diamondbacks vs Phillies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-112) | PHI: (-104)
• Spread: ARI: +1.5 (-182) | PHI: -1.5 (+150)
• Total: 9 -- Over: (-110) | Under: (-110)

Diamondbacks vs Phillies Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 8-8, 5.12 ERA vs Ranger Suarez (Phillies) - 12-6, 2.84 ERA

The probable pitchers are Eduardo Rodriguez (8-8) for the Diamondbacks and Ranger Suarez (12-6) for the Phillies. When Rodriguez starts, his team is 10-16-0 against the spread this season. Rodriguez's team has a record of 8-7 this season when he starts and they are the favorite on the moneyline. The Phillies have a 12-10-0 record against the spread in Suarez's starts. The Phillies have been the underdog on the moneyline in four of Suarez's starts this season, and they went 3-1 in those games.

Diamondbacks vs Phillies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (59.2%)

Diamondbacks vs Phillies Moneyline

• The Diamondbacks vs Phillies moneyline has Arizona as a -112 favorite, while Philadelphia is a -104 underdog on the road.

Diamondbacks vs Phillies Spread

• The Phillies are 1.5-run favorites against the spread for this matchup with the Diamondbacks. The Phillies are +150 to cover, while the Diamondbacks are -182 to cover as a 1.5-run underdog on the runline.

Diamondbacks vs Phillies Over/Under

• The Diamondbacks-Phillies game on Sept. 21 has been given an over/under of 9 runs. The over is set at -110 and the under at -110.

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Diamondbacks vs Phillies Betting Trends

• The Diamondbacks have been victorious in 45, or 52.9%, of the 85 contests they have been chosen as favorites in this season.
• This year Arizona has won 42 of 82 games when listed as at least -112 on the moneyline.
• The Diamondbacks and their opponents have gone over the total this season in 75 of their 151 opportunities.
• The Diamondbacks have posted a record of 75-76-0 against the spread this season.
• The Phillies have won 14 of the 30 games they were the moneyline underdog this season (46.7%).
• Philadelphia has a 14-13 record (winning 51.9% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Phillies have played in 148 games with an over/under set, and have combined with their opponents to go over the total 62 times (62-77-9).
• The Phillies have a 77-71-0 record ATS this season (covering 52% of the time).

Diamondbacks Player Leaders

• Geraldo Perdomo leads Arizona with an OBP of .391, plus a team-best slugging percentage of .462. He's batting .289 on the season.
• Among all qualifying hitters in MLB, he ranks 13th in batting average, fifth in on-base percentage, and 46th in slugging.
• Perdomo has recorded a base hit in 10 straight games. During his last 10 outings he is hitting .412 with four doubles, a triple, two home runs, nine walks and six RBIs.
• Corbin Carroll leads Arizona in total hits (141) this season while batting .258 with 77 extra-base hits. He's slugging .540 with an on-base percentage of .339.
• Among qualified hitters, he ranks 70th in batting average, 52nd in on-base percentage and sixth in slugging percentage.
• Carroll brings a six-game streak with at least one hit into this one. In his last 10 outings he is batting .270 with a double, a triple, nine walks and five RBIs.
• Ketel Marte has collected 127 base hits, an OBP of .374 and a slugging percentage of .504 this season.
• Marte has picked up a hit in two games in a row. During his last five outings he is batting .261 with two doubles, a home run and three RBIs.
• Gabriel Moreno has been key for Arizona with 72 hits, an OBP of .350 plus a slugging percentage of .447.
• Moreno brings a two-game hitting streak into this matchup. During his last five outings he is batting .176 with a double and five walks.

Phillies Player Leaders

• Kyle Schwarber has racked up 140 hits with a .369 on-base percentage, leading the Phillies in both categories. He's batting .243 and slugging .564.
• Including all the qualified players in MLB, his batting average is 103rd, his on-base percentage ranks 12th, and he is fourth in slugging.
• Bryce Harper is hitting .263 with 32 doubles, 27 home runs and 68 walks. He's slugging .498 with an on-base percentage of .360.
• Including all qualified players, his batting average places him 56th, his on-base percentage ranks 20th, and he is 17th in slugging.
• Bryson Stott is hitting .257 with 21 doubles, three triples, 12 home runs and 53 walks.
• Nick Castellanos is batting .255 with 27 doubles, two triples, 17 home runs and 31 walks.

Diamondbacks vs Phillies Head to Head

• 9/20/2025: 4-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/19/2025: 8-2 PHI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/4/2025: 11-9 ARI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/3/2025: 7-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/2/2025: 3-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/11/2024: 12-5 ARI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/10/2024: 11-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/9/2024: 3-2 ARI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/8/2024: 6-4 PHI (Favorite: Diamondbacks, Spread: -1.5, Total: 10.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/23/2024: 4-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -245, Underdog Moneyline: +200)

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