Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 10:14 p.m.

The MLB schedule on Sunday includes the San Diego Padres facing the Chicago White Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs White Sox Game Info

• San Diego Padres (83-71) vs. Chicago White Sox (58-96)
• Date: Sunday, September 21, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SDPA

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-188) | CHW: (+158)
• Spread: SD: -1.5 (-108) | CHW: +1.5 (-111)
• Total: 8 -- Over: (-110) | Under: (-110)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 4-3, 3.84 ERA vs Sean Burke (White Sox) - 4-10, 4.29 ERA

The Padres will give the ball to Michael King (4-3, 3.84 ERA), who is eyeing win No. 5 on the season, and the White Sox will turn to Sean Burke (4-10, 4.29 ERA). When King starts, his team is 4-9-0 against the spread this season. King's team has a record of 5-5 this season when he starts and they are the favorite on the moneyline. The White Sox have gone 12-9-0 against the spread when Burke starts. The White Sox have been the moneyline underdog in 21 of Burke's starts this season, and they went 9-12 in those matchups.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (63.7%)

Padres vs White Sox Moneyline

• San Diego is the favorite, -188 on the moneyline, while Chicago is a +158 underdog despite being at home.

Padres vs White Sox Spread

• The White Sox are +1.5 on the run line against the Padres. The White Sox are -111 to cover, and the Padres are -108.

Padres vs White Sox Over/Under

• The over/under for the Padres versus White Sox contest on Sept. 21 has been set at 8, with -110 odds on the over and -110 odds on the under.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have won in 49, or 59%, of the 83 contests they have been named as odds-on favorites in this year.
• This season San Diego has been victorious 14 times in 23 chances when named as a favorite of at least -188 on the moneyline.
• The Padres and their opponents have gone over in 66 of their 152 games with a total set by sportsbooks this season.
• In 152 games with a line this season, the Padres have a mark of 81-71-0 against the spread.
• The White Sox have won 37.2% of the games this season they were the underdog on the moneyline (54-91).
• Chicago has gone 15-39 in games it has played as a moneyline underdog with odds of +158 or longer (27.8%).
• The White Sox have had an over/under set by bookmakers 149 times, and have combined with opponents to go over the total in 68 of those games (68-73-8).
• The White Sox have collected an 85-64-0 record ATS this season (covering 57% of the time).

Padres Player Leaders

• Fernando Tatis Jr. is batting .266 with 27 doubles, two triples, 22 home runs and 88 walks. He has an on-base percentage of .368 while slugging .435.
• Among all qualified batters in the majors, his batting average ranks 47th, his on-base percentage ranks 13th, and he is 72nd in slugging.
• Tatis hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .421 with three walks.
• Manny Machado leads San Diego with 164 hits. He is batting .277 this season and has 59 extra-base hits. He's also slugging .465 with an on-base percentage of .337.
• He ranks 31st in batting average, 57th in on-base percentage and 47th in slugging among qualified hitters.
• Luis Arraez leads San Diego in slugging percentage (.385) powered by 40 extra-base hits.
• Arraez heads into this game with eight games in a row with at least one hit. During his last 10 outings he is batting .324 with a walk and three RBIs.
• Ramon Laureano has 24 home runs, 76 RBI and a batting average of .285 this season.

White Sox Player Leaders

• Miguel Vargas has racked up a team-high .309 on-base percentage. He's batting .228 and slugging .397.
• He ranks 134th in batting average, 112th in on-base percentage and 105th in slugging percentage among all qualifying batters in the majors.
• Andrew Benintendi has 16 doubles, two triples, 20 home runs and 39 walks while batting .240. He's slugging .431 with an on-base percentage of .306.
• Lenyn Sosa has racked up a team-high slugging percentage (.424) and paces the White Sox in hits (128).
• Chase Meidroth has 15 doubles, five home runs and 44 walks while hitting .267.

Padres vs White Sox Head to Head

• 9/19/2025: 4-3 CHW (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/22/2024: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -350, Underdog Moneyline: +280)
• 9/21/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/20/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 10/1/2023: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/30/2023: 6-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/29/2023: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 10/2/2022: 2-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2022: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/30/2022: 3-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)

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