Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 1:12 p.m.

The MLB slate on Sunday includes the San Diego Padres taking on the Chicago White Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs White Sox Game Info

• San Diego Padres (84-71) vs. Chicago White Sox (58-97)
• Date: Sunday, September 21, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SDPA

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-180) | CHW: (+152)
• Spread: SD: -1.5 (-108) | CHW: +1.5 (-111)
• Total: 8 -- Over: (-114) | Under: (-106)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 4-3, 3.84 ERA vs Sean Burke (White Sox) - 4-10, 4.29 ERA

The Padres will call on Michael King (4-3) versus the White Sox and Sean Burke (4-10). King's team is 4-9-0 against the spread in his starts this season. King's team is 5-5 this season when he starts and they are the moneyline favorite. The White Sox are 12-9-0 ATS in Burke's 21 starts that had a set spread. The White Sox have a 9-12 record in Burke's 21 starts this season when they were the moneyline underdog.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (63.6%)

Padres vs White Sox Moneyline

• The Padres vs White Sox moneyline has San Diego as a -180 favorite, while Chicago is a +152 underdog at home.

Padres vs White Sox Spread

• The White Sox are +1.5 on the run line against the Padres. The White Sox are -111 to cover, and the Padres are -108.

Padres vs White Sox Over/Under

• An over/under of 8 has been set for Padres-White Sox on Sept. 21, with the over being -114 and the under -106.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have won in 50, or 59.5%, of the 84 contests they have been named as odds-on favorites in this year.
• San Diego has a record of 17-9 when favored by -180 or more this year.
• The Padres' games have gone over the total in 67 of their 153 opportunities.
• The Padres have posted a record of 82-71-0 against the spread this season.
• The White Sox have gone 54-92 in games they were listed as the moneyline underdog (winning 37% of those games).
• Chicago is 19-44 (winning just 30.2% of its games) when playing as a moneyline underdog of +152 or longer.
• The White Sox have combined with opponents to hit the over on the total 69 times this season for a 69-73-8 record against the over/under.
• The White Sox have put together an 85-65-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is hitting .266 with 27 doubles, two triples, 22 home runs and 88 walks. He has an on-base percentage of .367 and a slugging percentage of .433.
• Among all qualifying batters in baseball, his batting average ranks 45th, his on-base percentage ranks 13th, and he is 71st in slugging.
• Tatis has recorded at least one hit in four games in a row. During his last five outings he is batting .300 with two walks.
• Manny Machado has 165 hits, which ranks first among San Diego batters this season. He's batting .276 with 59 extra-base hits. He's also slugging .462 with an on-base percentage of .336.
• He ranks 31st in batting average, 56th in on-base percentage and 46th in slugging in the major leagues.
• Luis Arraez has hit seven homers with a team-high .384 SLG this season.
• Arraez heads into this game with nine games in a row with at least one hit. During his last 10 outings he is batting .342 with a walk and four RBIs.
• Ramon Laureano is batting .282 with a .343 OBP and 76 RBI for San Diego this season.

White Sox Player Leaders

• Miguel Vargas a has .310 on-base percentage to lead the White Sox. He's batting .230 while slugging .400.
• He ranks 131st in batting average, 109th in on-base percentage and 101st in slugging percentage among all qualifying hitters in the majors.
• Andrew Benintendi has 16 doubles, two triples, 20 home runs and 39 walks while hitting .240. He's slugging .431 with an on-base percentage of .306.
• Lenyn Sosa has accumulated a team-best slugging percentage (.428) and paces the White Sox in hits (129).
• Chase Meidroth has 15 doubles, five home runs and 44 walks while batting .267.

Padres vs White Sox Head to Head

• 9/20/2025: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 9/19/2025: 4-3 CHW (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/22/2024: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -350, Underdog Moneyline: +280)
• 9/21/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/20/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 10/1/2023: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/30/2023: 6-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/29/2023: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 10/2/2022: 2-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2022: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)

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