USC vs Michigan State Prediction, Odds, Picks, Best Bets for Week 4 2025

The college football schedule on Saturday includes the USC Trojans taking on the Michigan State Spartans.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

USC vs Michigan State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-1099) | Michigan State: (+680)
• Spread: USC: -18.5 (-114) | Michigan State: +18.5 (-106)
• Total: 55.5 -- Over: (-110) | Under: (-110)

USC vs Michigan State Betting Trends

• USC has posted two wins against the spread this season.
• USC has won twice ATS (2-1) as an 18.5-point or bigger favorite this year.
• Two of three USC games have gone over the point total this season.
• Michigan State is winless against the spread this year.
• Michigan State has played two games (out of three) which finished over the total this year.

USC vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (84%)

USC vs Michigan State Point Spread

Michigan State is listed as an underdog by 18.5 points (-106 odds), and USC, the favorite, is -114 to cover.

USC vs Michigan State Over/Under

The over/under for the USC versus Michigan State matchup on Sept. 20 has been set at 55.5, with -110 odds on the over and -110 odds on the under.

USC vs Michigan State Moneyline

The moneyline numbers for USC vs. Michigan State reveal USC as the favorite (-1099) and Michigan State as the underdog (+680).

USC vs. Michigan State Points Insights

USC vs. Michigan State Game Info

• Game day: Saturday, September 20, 2025
• Game time: 11 p.m. ET
• TV channel: FOX
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth USC vs. Michigan State analysis on FanDuel Research.