Reds vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 7:13 p.m.

MLB action on Thursday includes the Cincinnati Reds playing the Chicago Cubs.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Reds vs Cubs Game Info

• Cincinnati Reds (76-76) vs. Chicago Cubs (88-64)
• Date: Thursday, September 18, 2025
• Time: 7:15 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FOX

Reds vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-142) | CHC: (+120)
• Spread: CIN: -1.5 (+138) | CHC: +1.5 (-166)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Reds vs Cubs Probable Starting Pitchers

Probable Pitchers: Hunter Greene (Reds) - 6-4, 3.01 ERA vs Colin Rea (Cubs) - 10-6, 4.23 ERA

The Reds will call on Hunter Greene (6-4) versus the Cubs and Colin Rea (10-6). When Greene starts, his team is 6-10-0 against the spread this season. Greene's team is 6-3 this season when he starts and they are the moneyline favorite. The Cubs have a 15-9-0 record against the spread in Rea's starts. The Cubs have been the underdog on the moneyline in seven of Rea's starts this season, and they went 5-2 in those matchups.

Reds vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (52.1%)

Reds vs Cubs Moneyline

• Cincinnati is a -142 favorite on the moneyline, while Chicago is a +120 underdog on the road.

Reds vs Cubs Spread

• The Cubs are +1.5 on the run line against the Reds. The Cubs are -166 to cover, and the Reds are +138.

Reds vs Cubs Over/Under

• A total of 8.5 runs has been set for the Reds-Cubs game on Sept. 18, with the over available at -105 and the under at -115.

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Reds vs Cubs Betting Trends

• The Reds have been chosen as favorites in 61 games this year and have walked away with the win 32 times (52.5%) in those games.
• This season Cincinnati has been victorious 10 times in 21 chances when named as a favorite of at least -142 on the moneyline.
• The Reds' games have gone over the total in 57 of their 145 opportunities.
• In 145 games with a line this season, the Reds have a mark of 75-70-0 against the spread.
• The Cubs have been the underdog on the moneyline 41 total times this season. They've gone 18-23 in those games.
• Chicago has a record of 5-6 when playing as a moneyline underdog with odds of +120 or longer (45.5%).
• The Cubs have had an over/under set by oddsmakers 148 times, and have combined with opponents to go over the total in 68 of those games (68-70-10).
• The Cubs have covered 47.3% of their games this season, going 70-78-0 ATS.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 156 hits and a team-best slugging percentage of .433. He's batting .263 with an on-base percentage of .334.
• He ranks 54th in batting average, 62nd in on-base percentage, and 72nd in slugging among all qualified hitters in the majors.
• TJ Friedl has 140 hits this season and a team-best OBP of .364. He's batting .259 and slugging .370.
• He is 68th in batting average, 15th in on-base percentage and 130th in slugging among qualifying hitters.
• Spencer Steer is batting .242 with a .405 slugging percentage and 69 RBI this year.
• Steer enters this game with two games in a row with at least one hit. During his last five outings he is batting .353 with a home run, three walks and five RBIs.
• Austin Hays is batting .266 with a .316 OBP and 64 RBI for Cincinnati this season.
• Hays has hit safely in two straight games. In his last five games he is hitting .263 with a walk.

Cubs Player Leaders

• Nico Hoerner has a .402 slugging percentage, which paces the Cubs. He's batting .303 with an on-base percentage of .353.
• Including all qualifying hitters in MLB, he is sixth in batting average, 33rd in on-base percentage and 101st in slugging percentage.
• Hoerner hopes to build on a 12-game hitting streak in this matchup. In his last 10 outings he is hitting .463 with four doubles, a triple, four walks and three RBIs.
• Pete Crow-Armstrong is batting .247 with 37 doubles, four triples, 29 home runs and 29 walks. He's slugging .484 with an on-base percentage of .289.
• Including all qualifying hitters, he ranks 97th in batting average, 137th in on-base percentage and 26th in slugging percentage.
• Ian Happ is hitting .243 with 28 doubles, 23 home runs and 85 walks.
• Seiya Suzuki is batting .243 with 29 doubles, three triples, 27 home runs and 67 walks.

Reds vs Cubs Head to Head

• 8/6/2025: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/5/2025: 5-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/4/2025: 3-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/1/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/31/2025: 2-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/30/2025: 6-2 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/25/2025: 11-8 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/24/2025: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/23/2025: 13-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 3-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)

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