USC vs Iowa Prediction, Odds, Picks, Best Bets for Week 12 2025

On Saturday in college football, the USC Trojans are playing the Iowa Hawkeyes.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding today's NCAA football betting odds.

USC vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-260) | Iowa: (+215)
• Spread: USC: -6.5 (-122) | Iowa: +6.5 (100)
• Total: 49.5 -- Over: (-110) | Under: (-110)

USC vs Iowa Betting Trends

• USC's record against the spread is 5-4-0.
• This season, USC is 3-3 as 6.5-point or better favorites.
• This season, five of USC's nine games have go over the point total.
• Against the spread, Iowa is 7-2-0 this year.
• Iowa has yet to lose ATS (1-0) as a 6.5-point underdog or more this year.
• Of nine Iowa games so far this year, four have gone over the total.

USC vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (68.6%)

USC vs Iowa Point Spread

USC is a 6.5-point favorite against Iowa. USC is -122 to cover the spread, and Iowa is +100.

USC vs Iowa Over/Under

The over/under for USC-Iowa on Nov. 15 is 49.5. The over is -110, and the under is -110.

USC vs Iowa Moneyline

Looking at the moneyline for Iowa-USC, Iowa is the underdog at +215, and USC is -260.

USC vs. Iowa Points Insights

USC vs. Iowa Game Info

• Game day: Saturday, November 15, 2025
• Game time: 3:30 p.m. ET
• TV channel: BTN
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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